Zobrazeno 1 - 10 of 169 pro vyhledávání: '"Joseph E Tomaszewski"'
1
Akademický článek
Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.
Autor: Tony Navas, Thomas D Pfister, Simona Colantonio, Amina Aziz, Lynda Dieckman, Richard G Saul, Jan Kaczmarczyk, Suzanne Borgel, Sergio Y Alcoser, Melinda G Hollingshead, Young H Lee, Donald P Bottaro, Tara Hiltke, Gordon Whiteley, Naoko Takebe, Robert J Kinders, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0199361 (2018)
The presence of cancer stem cells (CSCs) and the induction of epithelial-to-mesenchymal transition (EMT) in tumors are associated with tumor aggressiveness, metastasis, drug resistance, and poor prognosis, necessitating the development of reagents fo
Externí odkaz: https://doaj.org/article/f5177b4e279648b6b9d11f4b1381c950
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2
Akademický článek
Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.
Autor: Jiuping Ji, Yiping Zhang, Christophe E Redon, William C Reinhold, Alice P Chen, Laura K Fogli, Susan L Holbeck, Ralph E Parchment, Melinda Hollingshead, Joseph E Tomaszewski, Quentin Dudon, Yves Pommier, James H Doroshow, William M Bonner
Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171582 (2017)
Phosphorylated H2AX (γ-H2AX) is a sensitive marker for DNA double-strand breaks (DSBs), but the variability of H2AX expression in different cell and tissue types makes it difficult to interpret the meaning of the γ-H2AX level. Furthermore, the assa
Externí odkaz: https://doaj.org/article/c5271db0c4334b48803bddf775b6a904
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3
Akademický článek
Antibody-independent capture of circulating tumor cells of non-epithelial origin with the ApoStream® system.
Autor: Priya Balasubramanian, Robert J Kinders, Shivaani Kummar, Vishal Gupta, David Hasegawa, Anoop Menachery, Scott M Lawrence, Lihua Wang, Katherine Ferry-Galow, Darren Davis, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175414 (2017)
Circulating tumor cells (CTCs) are increasingly employed for research and clinical monitoring of cancer, though most current methods do not permit the isolation of non-epithelial tumor cells. Furthermore, CTCs isolated with antibody-dependent methods
Externí odkaz: https://doaj.org/article/5a1c9b8ca8394270b95ad7bdc380301a
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4
Akademický článek
Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues.
Autor: Thomas D Pfister, Melinda Hollingshead, Robert J Kinders, Yiping Zhang, Yvonne A Evrard, Jiuping Ji, Sonny A Khin, Suzanne Borgel, Howard Stotler, John Carter, Raymond Divelbiss, Shivaani Kummar, Yves Pommier, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50494 (2012)
Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS) trial demonstrated that nuclear staining of Top1 correlates with chemotherapeutic efficacy. Such a c
Externí odkaz: https://doaj.org/article/fc45c0d607034df99dbf3dba3216402a
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5
Akademický článek
Modeling pharmacodynamic response to the poly(ADP-Ribose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells.
Autor: Jiuping Ji, Robert J Kinders, Yiping Zhang, Larry Rubinstein, Shivaani Kummar, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26152 (2011)
Poly(ADP-ribose) polymerase (PARP) facilitates DNA repair and PARP inhibitors may potentiate the effect of DNA-damaging chemotherapeutic agents in patients with cancer. Collection of peripheral blood mononuclear cells (PBMCs) as a surrogate tissue to
Externí odkaz: https://doaj.org/article/c2dc595de21b4c068a9d2e559732574d
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8
Data from Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts
Autor: Ralph E. Parchment, James H. Doroshow, Joseph E. Tomaszewski, Larry Rubinstein, Sonny Khin, Melinda Hollingshead, Robert J. Kinders
Purpose: The National Cancer Institute has completed a first-in-human clinical pharmacodynamic trial of the targeted agent ABT-888, a poly (ADP-ribose) polymerase (PARP) inhibitor, under the auspices of the U.S. Food and Drug Administration's Explora
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ad9f2a7c91ef0117e05db97559bf25
https://doi.org/10.1158/1078-0432.c.6517116.v1
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9
Data from Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells
Autor: Robert J. Kinders, James H. Doroshow, Joseph E. Tomaszewski, Anthony J. Murgo, Martin E. Gutierrez, Yvonne A. Evrard, Larry Rubinstein, Shivaani Kummar, Ralph E. Parchment, Thomas D. Pfister, Lihua H. Wang
Purpose: Circulating tumor cells (CTC) in peripheral blood of patients potentially represent a fraction of solid tumor cells available for more frequent pharmacodynamic assessment of drug action than is possible using tumor biopsy. However, currently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60a236e106e8634cb694f012d26d42f
https://doi.org/10.1158/1078-0432.c.6519651
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