Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Joseph E Rabinowitz"'
Autor:
Davy Vanhoutte, Tobias G Schips, Jennifer Q Kwong, Jennifer Davis, Andoria Tjondrokoesoemo, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Hong Yi, Quan Q Gao, Joseph E Rabinowitz, Talila Volk, Elizabeth M McNally, Jeffery D Molkentin
Publikováno v:
eLife, Vol 5 (2016)
Skeletal muscle is highly sensitive to mutations in genes that participate in membrane stability and cellular attachment, which often leads to muscular dystrophy. Here we show that Thrombospondin-4 (Thbs4) regulates skeletal muscle integrity and its
Externí odkaz:
https://doaj.org/article/211d0d632f9543a2ab9249ddaf6593b3
Autor:
Jessica I Gold, Jeffrey S Martini, Jonathan Hullmann, Erhe Gao, J Kurt Chuprun, Linda Lee, Douglas G Tilley, Joseph E Rabinowitz, Julie Bossuyt, Donald M Bers, Walter J Koch
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57324 (2013)
G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte g
Externí odkaz:
https://doaj.org/article/f933052fcc7e42b0bf320c5f5af94e73
Autor:
Joseph E. Rabinowitz, Christopher E. Henderson, Christian M. Simon, Livio Pellizzoni, Ya Dai, Joshua I. Chalif, John G. Pagiazitis, Charalampia Koutsioumpa, Meaghan Van Alstyne, George Z. Mentis, Xiaojian Wang
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3767-3780 (2017)
Summary The hallmark of spinal muscular atrophy (SMA), an inherited disease caused by ubiquitous deficiency in the SMN protein, is the selective degeneration of subsets of spinal motor neurons. Here, we show that cell-autonomous activation of p53 occ
Autor:
Guofeng Gao, Jennifer Gordon, Feifei Su, Joseph Y. Cheung, Muniswamy Madesh, Jianliang Song, Joseph E. Rabinowitz, Valerie D. Myers, Erhe Gao, Manish K. Gupta, Kamel Khalili, Frederick V. Ramsey, Douglas G. Tilley, Tijana Knezevic, Xue-Qian Zhang, JuFang Wang, Kristen N. Weiner, Arthur M. Feldman
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 647-656 (2016)
The present study was undertaken to test the hypothesis that gene delivery of BCL2-Associated Athanogene 3 (BAG3) to the heart of mice with left ventricular dysfunction secondary to a myocardial infarction could enhance cardiac performance.BAG3 is a
Autor:
Andrés Pun García, Christopher J. Traynham, Walter J. Koch, Borja Ibanez, Daohai Yu, Laurel A. Grisanti, Rhonda L. Carter, Ashley A. Repas, Douglas G. Tilley, Anna M. Gumpert, Joshua Gorsky, John W. Calvert, Joseph E. Rabinowitz, Erhe Gao
Publikováno v:
Circulation. 134:153-167
Background: Immune cell–mediated inflammation is an essential process for mounting a repair response after myocardial infarction (MI). The sympathetic nervous system is known to regulate immune system function through β-adrenergic receptors (βARs
Autor:
Arthur M. Feldman, JuFang Wang, Valerie D. Myers, Jianliang Song, Xue-Qian Zhang, Kamel Khalili, Douglas G. Tilley, Feifei Su, Walter J. Koch, Jennifer Gordon, Joseph E. Rabinowitz, Joseph Y. Cheung, Erhe Gao, Muniswamy Madesh, Nicholas E. Hoffman, Dhanendra Tomar
Publikováno v:
Journal of Molecular and Cellular Cardiology. 92:10-20
Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to loss of protein, are associated with familial cardiomyopathy. Furthermore, BA
Autor:
Kamel Khalili, Douglas G. Tilley, Joseph E. Rabinowitz, Erhe Gao, Walter J. Koch, Arthur M. Feldman, Xue-Qian Zhang, Joseph Y. Cheung, Jianliang Song, Paul E. Klotman, Jennifer Gordon, JuFang Wang
Publikováno v:
Clinical and Translational Science. 8:305-310
Since highly active antiretroviral therapy improved long-term survival of acquired immunodeficiency syndrome (AIDS) patients, AIDS cardiomyopathy has become an increasingly relevant clinical problem. We used human immunodeficiency virus (HIV)-1 trans
Autor:
Steven R. Houser, Xue-Qian Zhang, Amy L. Tucker, JuFang Wang, Blaise Z. Peterson, Joseph E. Rabinowitz, Xiongwen Chen, Joseph Y. Cheung, Jianliang Song, Arthur M. Feldman
Publikováno v:
Journal of Molecular and Cellular Cardiology. 84:104-111
We evaluated whether phospholemman (PLM) regulates L-type Ca2 + current (ICa) in mouse ventricular myocytes. Expression of α1-subunit of L-type Ca2 + channels between wild-type (WT) and PLM knockout (KO) hearts was similar. Compared to WT myocytes,
Autor:
Joseph E. Rabinowitz, Federica Accornero, Allen J. York, John W. Elrod, Michelle A. Sargent, Jop H. van Berlo, Robert N. Correll, Jeffery D. Molkentin, Andrew Leask
Publikováno v:
Molecular and Cellular Biology. 35:2154-2164
The matricellular secreted protein connective tissue growth factor (CTGF) is upregulated in response to cardiac injury or with transforming growth factor β (TGF-β) stimulation, where it has been suggested to function as a fibrotic effector. Here we
Autor:
Jianmin Gu, Rong Cai, Wenhan Mei, Jinke Cheng, Yibin Wang, Haipeng Sun, Xiaobing Liu, Shuxun Ren, Song Xue, Joseph E. Rabinowitz, Edward T.H. Yeh, Yitao Qi
Publikováno v:
Journal of Molecular and Cellular Cardiology. 79:115-122
Defect in mitochondrial biogenesis and cardiac energy metabolism is a critical contributing factor to cardiac hypertrophy and heart failure. Sentrin/SUMO specific protease 1 (SENP1) mediated regulation of PGC-1α transcriptional activity plays an ess