Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Joseph E Chambers"'
Publikováno v:
eLife, Vol 6 (2017)
Dephosphorylation of translation initiation factor 2 (eIF2α) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a promising target for modifying the course of protein misfolding diseases. The [(o-chlorobenzyli
Externí odkaz:
https://doaj.org/article/eaeb5ea53149482887af33b21ec3a20b
Autor:
Steffen Preissler, Joseph E Chambers, Ana Crespillo-Casado, Edward Avezov, Elena Miranda, Juan Perez, Linda M Hendershot, Heather P Harding, David Ron
Publikováno v:
eLife, Vol 4 (2015)
DnaK/Hsp70 chaperones form oligomers of poorly understood structure and functional significance. Site-specific proteolysis and crosslinking were used to probe the architecture of oligomers formed by the endoplasmic reticulum (ER) Hsp70, BiP. These we
Externí odkaz:
https://doaj.org/article/645adf268a244bb8b406109511db4a8a
Autor:
Joseph E Chambers, Lucy E Dalton, Hanna J Clarke, Elke Malzer, Caia S Dominicus, Vruti Patel, Greg Moorhead, David Ron, Stefan J Marciniak
Publikováno v:
eLife, Vol 4 (2015)
Four stress-sensing kinases phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF2α) to activate the integrated stress response (ISR). In animals, the ISR is antagonised by selective eIF2α phosphatases comprising a cata
Externí odkaz:
https://doaj.org/article/cdfe0399553f43a3b9c0c2a15cc1ae87
Autor:
Carlos Bravo-Pérez, Mara Toderici, Joseph E. Chambers, José A. Martínez-Menárguez, Pedro Garrido-Rodriguez, Horacio Pérez-Sanchez, Belén de la Morena-Barrio, José Padilla, Antonia Miñano, Rosa Cifuentes-Riquelme, Vicente Vicente, Maria L. Lozano, Stefan J. Marciniak, Maria Eugenia de la Morena-Barrio, Javier Corral
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Antithrombin, a major endogenous anticoagulant, is a serine protease inhibitor (serpin). We characterized the biological and clinical impact of variants involving C-terminal antithrombin. We performed comprehensive molecular, cellular, and clinical c
Externí odkaz:
https://doaj.org/article/cf7e36928b7b4d52938fbf1f78f614fd
Autor:
Karolína Straková, Javier López-Andarias, Noemi Jiménez-Rojo, Joseph E. Chambers, Stefan J. Marciniak, Howard Riezman, Naomi Sakai, Stefan Matile
Publikováno v:
ACS Central Science, Vol 6, Iss 8, Pp 1376-1385 (2020)
Externí odkaz:
https://doaj.org/article/2cbf73242a1f433bb8c220a3ef07b9c5
Autor:
Elke Malzer, Caia S. Dominicus, Joseph E. Chambers, Jennifer A. Dickens, Souradip Mookerjee, Stefan J. Marciniak
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Background Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress-sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and developmental consequen
Externí odkaz:
https://doaj.org/article/5973834f202b4f20b2f53a600a1928a6
Autor:
Jonathon Nixon-Abell, Francesco S. Ruggeri, Seema Qamar, Therese W. Herling, Magdalena A. Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S. Fernandopulle, Tomas Sneideris, Joseph L. Watson, Visakh V.S. Pillai, William Meadows, James W. Henderson, Joseph E. Chambers, Jane L. Wagstaff, Sioned H. Williams, Helena Coyle, Yuqian Lu, Shuyuan Zhang, Stefan J. Marciniak, Stefan M.V. Freund, Emmanuel Derivery, Michael E. Ward, Michele Vendruscolo, Tuomas P.J. Knowles, Peter St George-Hyslop
Publikováno v:
bioRxiv
SUMMARYPhase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. The frequent juxtaposition of proteinaceous biomolecular condensates to cellular membranes raises the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33defe860df5665cc889d6dd86e39881
https://europepmc.org/articles/PMC10055329/
https://europepmc.org/articles/PMC10055329/
Publikováno v:
Cells, Vol 10, Iss 2, p 233 (2021)
Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS pro
Externí odkaz:
https://doaj.org/article/b4b7ccd9ac4b4d84a11e9b8e177c862a
Autor:
Joseph E. Chambers, Nikita Zubkov, Markéta Kubánková, Jonathon Nixon-Abell, Ioanna Mela, Susana Abreu, Max Schwiening, Giulia Lavarda, Ismael López-Duarte, Jennifer A. Dickens, Tomás Torres, Clemens F. Kaminski, Liam J. Holt, Edward Avezov, James A. Huntington, Peter St George-Hyslop, Marina K. Kuimova, Stefan J. Marciniak
Publikováno v:
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
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Misfolding of secretory proteins in the endoplasmic reticulum (ER) features in many human diseases. In α1-antitrypsin deficiency, the pathogenic Z variant aberrantly assembles into polymers in the hepatocyte ER, leading to cirrhosis. We show that α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cc97a8f6c535f431275217bec99ecb
Autor:
Joseph E, Chambers, Nikita, Zubkov, Markéta, Kubánková, Jonathon, Nixon-Abell, Ioanna, Mela, Susana, Abreu, Max, Schwiening, Giulia, Lavarda, Ismael, López-Duarte, Jennifer A, Dickens, Tomás, Torres, Clemens F, Kaminski, Liam J, Holt, Edward, Avezov, James A, Huntington, Peter St, George-Hyslop, Marina K, Kuimova, Stefan J, Marciniak
Publikováno v:
Science advances. 8(14)
Misfolding of secretory proteins in the endoplasmic reticulum (ER) features in many human diseases. In α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78ff95963ee86c59ebea920b79abd7ca
https://pubmed.ncbi.nlm.nih.gov/35394846
https://pubmed.ncbi.nlm.nih.gov/35394846