Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Joseph E, Saavedra"'
Autor:
Max Heckler, Nadja Osterberg, Jessica Guenzle, Nina Kristin Thiede-Stan, Wilfried Reichardt, Claudia Weidensteiner, Joseph E Saavedra, Astrid Weyerbrock
Publikováno v:
Tumor Biology, Vol 39 (2017)
As a potent radiosensitizer nitric oxide (NO) may be a putative adjuvant in the treatment of malignant gliomas which are known for their radio- and chemoresistance. The NO donor prodrug JS-K (O2-(2.4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-y
Externí odkaz:
https://doaj.org/article/9208c2cddd6745f8b8556917ad7999ed
Autor:
Anna E. Maciag, Ryan J. Holland, Y.-S. Robert Cheng, Luis G. Rodriguez, Joseph E. Saavedra, Lucy M. Anderson, Larry K. Keefer
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 115-124 (2013)
JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metaboli
Externí odkaz:
https://doaj.org/article/96cd776291404d5f928d6f807e7ad475
Publikováno v:
The Journal of organic chemistry. 64(14)
Synthetic procedures have been devised to exploit the bifunctional amine piperazine (pip) as a linker capable of attaching the nitric oxide (NO)-releasing diazeniumdiolate functional group [N(O)NO]- to a diverse selection of biomedically useful molec
Autor:
Huan Wang, Guangmin Li, Joseph E. Saavedra, Jie Liu, Zhengyun Liu, Guo Luo, Dongyan Xiao, Ying Gou
Publikováno v:
Biomedicine & Pharmacotherapy. 92:989-997
Hepatocellular carcinoma (HCC) is the most important cause of cancer-related death, and 85% of HCC is caused by chronic HBV infection, the prognosis of patients and the reduction of HBV DNA levels remain unsatisfactory. JS-K, a nitric oxide-releasing
Publikováno v:
Biomedicine & Pharmacotherapy. 88:367-373
JS-K is a novel anticancer nitric oxide (NO) prodrug effective against a variety of cancer cells, including the inhibition of AM-1 hepatoma cell growth in rats. To further evaluate anticancer effects of JS-K, human hepatoma Hep3B cells were treated w
Autor:
Joseph E. Saavedra, Nina Kristin Thiede-Stan, Claudia Weidensteiner, Wilfried Reichardt, Nadja Osterberg, Max Heckler, Astrid Weyerbrock, Jessica Guenzle
Publikováno v:
Tumor Biology, Vol 39 (2017)
As a potent radiosensitizer nitric oxide (NO) may be a putative adjuvant in the treatment of malignant gliomas which are known for their radio- and chemoresistance. The NO donor prodrug JS-K (O2-(2.4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-y
Autor:
Valentyna I. Fesenkova, Larry K. Keefer, Charlotte Hanson, Monika Z. Kaczmarek, Stephen A. Lavanier, Ryan J. Holland, Joseph E. Saavedra, Jami A. Troxler, Joan L. Cmarik, Sandra K. Ruscetti
Publikováno v:
Leukemia Research. 38:377-382
The nitric oxide (NO) prodrug JS-K, a promising anti-cancer agent, consists of a diazeniumdiolate group necessary for the release of NO as well as an arylating ring. In this study, we research the mechanism by which JS-K kills a murine erythroleukemi
Autor:
Larry K. Keefer, Rika Paulisch, Ryan J. Holland, Sonia Donzelli, Joseph E. Saavedra, Zhao Cao
Publikováno v:
Nitric Oxide. 35:131-136
We introduce a strategy for generating mixtures of nitric oxide (NO) and nitroxyl (HNO) at tunable rates in physiological media. The approach involves converting a spontaneously HNO/NO-generating ion to a caged (prodrug) form that is essentially stab
Autor:
Astrid Weyerbrock, Paul J. Shami, Joseph E. Saavedra, Brunhilde Baumer, Claudia Weidensteiner, Wilfried Reichardt, Nadja Osterberg, Anna Werres, Robert Jasinski, Larry K. Keefer
Publikováno v:
Nitric Oxide. 30:17-25
Nitric oxide (NO) released from NO donors can be cytotoxic in tumor cells and can enhance the transport of drugs into brain tumors by altering blood-tumor barrier permeability. The NO donor JS-K [ O 2 -(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperaz
Autor:
Larry K. Keefer, Luis G. Rodriguez, Ryan J. Holland, Lucy M. Anderson, Y.-S. Robert Cheng, Joseph E. Saavedra, Anna E. Maciag
Publikováno v:
Redox Biology
Redox Biology, Vol 1, Iss 1, Pp 115-124 (2013)
Redox Biology, Vol 1, Iss 1, Pp 115-124 (2013)
JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metaboli