Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joseph E, Rupert"'
Autor:
Alexandra Aguilar-Perez, Rafael Pacheco-Costa, Emily G. Atkinson, Padmini Deosthale, Hannah M. Davis, Alyson L. Essex, Julian E. Dilley, Leland Gomez, Joseph E. Rupert, Teresa A. Zimmers, Roger J. Thompson, Matthew R. Allen, Lilian I. Plotkin
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Pannexins (Panxs), glycoproteins that oligomerize to form hemichannels on the cell membrane, are topologically similar to connexins, but do not form cell-to-cell gap junction channels. There are 3 members of the family, 1–3, with Panx1 bei
Externí odkaz:
https://doaj.org/article/97573a8376fe40a69c68de24c809d8bf
Autor:
Joseph E. Rupert, Mikhail G. Kolonin
Publikováno v:
Immunometabolism (Cobham (Surrey, England)). 4(3)
Dysregulation of lipid deposition into and mobilization from white adipose tissue (WAT) underlies various diseases. Long-chain fatty acids (LCFA) and cholesterol trafficking in and out of adipocytes is a process relying on transporters shuttling lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf6394036e45a6313589f6e9b0d4ac7
https://pubmed.ncbi.nlm.nih.gov/35991116
https://pubmed.ncbi.nlm.nih.gov/35991116
Autor:
Daenique H.A. Jengelley, Meijing Wang, Ashok Narasimhan, Joseph E. Rupert, Andrew R. Young, Xiaoling Zhong, Daniel J. Horan, Alexander G. Robling, Leonidas G. Koniaris, Teresa A. Zimmers
Publikováno v:
Cytokine. 159
Musculoskeletal diseases such as muscular dystrophy, cachexia, osteoarthritis, and rheumatoid arthritis impair overall physical health and reduce survival. Patients suffer from pain, dysfunction, and dysmobility due to inflammation and fibrosis in bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5c08a76d68ecf787ec0a6ff09ad54c
https://pubmed.ncbi.nlm.nih.gov/36054964
https://pubmed.ncbi.nlm.nih.gov/36054964
Autor:
Daenique H. Jengelley, Ashok Narasimhan, Joseph E. Rupert, Xiaoling Zhong, Andrew R. Young, Leonidas G. Koniaris, Teresa A. Zimmers
Publikováno v:
Cancer Research. 82:3210-3210
Cancer cachexia is the involuntary loss of body weight, skeletal muscle, and adipose tissue associated with disease. Cachexia affects 85% of pancreatic cancer patients and patients suffer the greatest average weight loss among solid cancers. Inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e3855427293d57fc85026c8a9801bec
https://doi.org/10.1158/1538-7445.am2022-3210
https://doi.org/10.1158/1538-7445.am2022-3210
Autor:
Teresa A. Zimmers, Andrea Bonetto, Joseph E. Rupert, Ashok Narasimhan, Thomas M. O’Connell, Leonidas G. Koniaris, Yunlong Liu
Most patients with pancreatic adenocarcinoma (PDAC) suffer unintentional weight loss, or cachexia. Interleukin-6 causes cachexia in mice and associates with mortality in PDAC. Here we show that tumor cell-derived IL-6 mediates crosstalk between tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65854280babcc6ac86170b563c67eb65
https://doi.org/10.1101/2020.09.16.300798
https://doi.org/10.1101/2020.09.16.300798
Autor:
Yan Tong, Michelle Grimard, Jack McGeown, Rachel A. Caston, Roberto Pili, Mark R. Kelley, Colton L. Starcher, Melissa L. Fishel, Fenil Shah, Karen E. Pollok, Teresa A. Zimmers, Joseph E. Rupert, Olivia Babb, Lee Armstrong, Adily N. Elmi, Edward A. Motea, Randall Wireman
Publikováno v:
Journal of Cellular and Molecular Medicine
With a plethora of molecularly targeted agents under investigation in cancer, a clear need exists to understand which pathways can be targeted simultaneously with multiple agents to elicit a maximal killing effect on the tumour. Combination therapy p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73f621142688f261082a02af021cd8a
https://pubmed.ncbi.nlm.nih.gov/33274592
https://pubmed.ncbi.nlm.nih.gov/33274592
Publikováno v:
Shock (Augusta, Ga.)
Trauma, burn injury, sepsis, and ischemia lead to acute and chronic loss of skeletal muscle mass and function. Healthy muscle is essential for eating, posture, respiration, reproduction, and mobility, as well as for appropriate function of the senses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa822a46beb32d23e67e2327a2e4f31a
https://pubmed.ncbi.nlm.nih.gov/31939770
https://pubmed.ncbi.nlm.nih.gov/31939770
Publikováno v:
The Anatomical Record. 301:434-440
The musculoskeletal system is remarkably plastic during growth. The purpose of this study was to examine the muscular plasticity in functional and structural properties in a model known to result in significant developmental plasticity of the postcra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff6567b49ab73b4d72154d8c4e517e58
https://doi.org/10.1002/ar.23744
https://doi.org/10.1002/ar.23744
Autor:
Teresa A. Zimmers, Andrea Bonetto, Joseph E. Rupert, Joshua R. Huot, Daenique H A Jengelley, Ashok Narasimhan
Publikováno v:
Cancer Research. 81:969-969
Approximately 80% of patients with pancreatic ductal adenocarcinoma (PDAC) suffer cachexia, involuntary loss of fat and muscle due to inflammation and dysmetabolism that increases treatment toxicity, reduces treatment response and promotes mortality.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b5e0e3780df4bb53d8a6238e034b409
https://doi.org/10.1158/1538-7445.am2021-969
https://doi.org/10.1158/1538-7445.am2021-969
Publikováno v:
Proceedings of IMPRS. 2
Background: Cachexia, manifested as progressive adipose and muscle wasting, affects up to 80% of patients with pancreatic ductal adenocarcinoma (PDAC) and significantly increases morbidity and mortality. Increased inflammation is an underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5249762e9a1373a8673c74f87d83cd28
https://doi.org/10.18060/23710
https://doi.org/10.18060/23710