Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Joseph E, Qualls"'
Autor:
Heather M. Evans, Destiny F. Schultz, Adam J. Boiman, Melanie C. McKell, Joseph E. Qualls, George S. Deepe
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Hypoxia-inducible factor 1α (HIF-1α) regulates the immunometabolic phenotype of macrophages, including the orchestration of inflammatory and antimicrobial processes. Macrophages deficient in HIF-1α produce excessive quantities of the anti
Externí odkaz:
https://doaj.org/article/c030846ab2494680a642e283c692126d
Autor:
Melanie C. McKell, Rebecca R. Crowther, Stephanie M. Schmidt, Michelle C. Robillard, Rachel Cantrell, Maria A. Lehn, Edith M. Janssen, Joseph E. Qualls
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages are indispensable immune cells tasked at eliminating intracellular pathogens. Mycobacterium tuberculosis (Mtb), one of the most virulent intracellular bacterial pathogens known to man, infects and resides within macrophages. While macroph
Externí odkaz:
https://doaj.org/article/b6fbae7edb794379b09f502c787ed320
Autor:
Rebecca R. Crowther, Joseph E. Qualls
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a leading cause of death worldwide. Despite decades of research, there is still much to be uncovered regarding the immune response to Mtb infection. Here, we summarize the
Externí odkaz:
https://doaj.org/article/238d27064cdb403ba1b3fa7a30372e8c
Autor:
Moises A. Huaman, Joseph E. Qualls, Shinsmon Jose, Stephanie M. Schmidt, Anissa Moussa, David G. Kuhel, Eddy Konaniah, Ravi K. Komaravolu, Carl J. Fichtenbaum, George S. Deepe, David Y. Hui
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis has been associated with increased risk of atherosclerotic cardiovascular disease. To examine whether mycobacterial infection exacerbates atherosclerosis development in experimental conditions, we infected low-density lipoprotein recepto
Externí odkaz:
https://doaj.org/article/bb4e7aeae6654bfcbd4ef24ab2d2321f
Autor:
Jarren R. Oates, Melanie C. McKell, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, George S. Deepe, Joseph E. Qualls, Senad Divanovic
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Obesity is a prevalent predisposing factor to non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the developed world. NAFLD spectrum of disease involves progression from steatosis (NAFL), to steatohepatitis (NASH), ci
Externí odkaz:
https://doaj.org/article/0e1438d604a745b8873224b13b844fb6
Autor:
Peter J. Murray, Pavel Kovarik, Hongbo Chi, Lee-Ann Van De Velde, Joseph E. Qualls, Nina Gratz, Franz Kratochvill
Representative Flow Cytometry plots for the detection of cytokine positive CD11b+ TAMs from WT and p38aΔH mice as analyzed in Fig. 6C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cece4a28c3f018cb0c33e1e448ee10
https://doi.org/10.1158/0008-5472.22405095.v1
https://doi.org/10.1158/0008-5472.22405095.v1
Autor:
Peter J. Murray, Pavel Kovarik, Hongbo Chi, Lee-Ann Van De Velde, Joseph E. Qualls, Nina Gratz, Franz Kratochvill
Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ebc3a0209e8b17ed82d42eb0e5d958
https://doi.org/10.1158/0008-5472.22405092.v1
https://doi.org/10.1158/0008-5472.22405092.v1
Autor:
Rebecca R. Crowther, Stephanie M. Schmidt, Shannon M. Lange, Melanie C. McKell, Michelle C. Robillard, Junfang Zhao, Wendy D. Haffey, Michael A. Wyder, Kenneth D. Greis, Kenneth D. R. Setchell, Joseph E. Qualls
Publikováno v:
The Journal of Immunology. 208:793-798
Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32417746bdf2b1490c1024d4fb3b408c
https://doi.org/10.4049/jimmunol.2100652
https://doi.org/10.4049/jimmunol.2100652
Autor:
Franz Kratochvill, Geoffrey Neale, Jessica M. Haverkamp, Lee-Ann Van de Velde, Amber M. Smith, Daisuke Kawauchi, Justina McEvoy, Martine F. Roussel, Michael A. Dyer, Joseph E. Qualls, Peter J. Murray
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1902-1914 (2015)
Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-associated macrophages (TAMs) infiltrate and adopt different activation states between anti-tumor M1 and pro-tumor M2 phenotypes. Here, we resolve a cascade caus
Externí odkaz:
https://doaj.org/article/167d3a6dabd5488ea9ac2f892da328e5
Autor:
Shannon M. Lange, Melanie C. McKell, Stephanie M. Schmidt, Austin P. Hossfeld, Vandana Chaturvedi, Jeremy M. Kinder, Jaclyn W. McAlees, Ian P. Lewkowich, Sing Sing Way, Joanne Turner, Joseph E. Qualls
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Activation, recruitment, and effector function of T lymphocytes are essential for control of mycobacterial infection. These processes are tightly regulated in T cells by the availability of l-arginine within the microenvironment. In turn, mycobacteri
Externí odkaz:
https://doaj.org/article/f779cae316be4969ae70c09a704d3f52