Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Joseph E, Coyle"'
Autor:
Michael Reader, Aurélie Courtin, Steven Howard, Nicola G. Wallis, Jonathan Shannon, Hugh Walton, Christopher William Murray, Joseph E. Coyle, Joanne M. Munck, Alison Jo-Anne Woolford, Torren M. Peakman, David C. Rees, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Marc O'Reilly, Alpesh Shah, David Norton, Valerio Berdini, Lynsey Fazal, Maria Grazia Carr, Charlotte East, Tom D. Heightman, Nicola E. Wilsher, Ildiko Maria Buck, Luke Bevan, Stuart Thomas Onions, Michael Cooke, Justyna Kucia-Tran, Sandra Muench, Nick Palmer, Sharna J. Rich, Vanessa Martins, David Cousin, Puja Pathuri, John P. Watts
Publikováno v:
Journal of medicinal chemistry. 64(16)
Aberrant activation of the mitogen-activated protein kinase pathway frequently drives tumor growth, and the ERK1/2 kinases are positioned at a key node in this pathway, making them important targets for therapeutic intervention. Recently, a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d0e8543148c5c72af0eca510047c9f
https://pubmed.ncbi.nlm.nih.gov/34387469
https://pubmed.ncbi.nlm.nih.gov/34387469
Autor:
Yann Dudit, Zehong Wan, Don O. Somers, Yingxia Sang, Vipulkumar Kantibhai Patel, Pascal Grondin, Joseph E. Coyle, Veronique Beneton, Rachel McMenamin, Lee William Page, Philip J. Day, Alison Jo-Anne Woolford, Lionel Trottet, Valerio Berdini, Florent Potvain, Sharna J. Rich, Christopher William Murray, Pascal Huet, Lydia Y. W. Lee, Xiaomin Zhang, Eric S. Manas
Publikováno v:
Journal of Medicinal Chemistry. 59:10738-10749
Lp-PLA2 has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e0ae2687867d1f42424c9a09ec700b8
https://doi.org/10.1021/acs.jmedchem.6b01427
https://doi.org/10.1021/acs.jmedchem.6b01427
Autor:
Emiliano Tamanini, Joseph E. Coyle, Agnes C. L. Martin, Adam Hold, Elisabetta Chiarparin, Sharna J. Rich, Ludovic Drouin, Puja Pathuri, Rob L. M. van Montfort, Tom D. Heightman, Marcello Tortorici, Finn P. Holding, Jeff Yon, Amy Wood, Rosemary Burke, Fiona Jeganathan, Yvette Newbatt, Nader Amin, Jenny E. Harmer, Maura Westlake, Paul Acklam, Swen Hoelder, Valerio Berdini, Dominic Tisi
Publikováno v:
ACS Chemical Biology. 11:3093-3105
The members of the NSD subfamily of lysine methyl transferases are compelling oncology targets due to the recent characterization of gain-of-function mutations and translocations in several hematological cancers. To date, these proteins have proven i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b87831640666c49d5bf755877b17f0
https://doi.org/10.1021/acschembio.6b00308
https://doi.org/10.1021/acschembio.6b00308
Autor:
Kirsten V. Smith, Joseph E. Pero, Ralph A. Rivero, Donald O. Somers, Vipulkumar Kantibhai Patel, Agnes C. L. Martin, Rachel McMenamin, Sridhar Aravapalli, Finn P. Holding, Eric S. Manas, Lionel Trottet, Alison Jo-Anne Woolford, Neipp Christopher E, Lydia Y. W. Lee, Ranganadh Velagaleti, Sharna J. Rich, Ren Xie, Peng Li, Glyn Williams, Andrew M. Dodson, Brent W. Mccleland, Lee William Page, Joseph P. Marino, Pascal Grondin, Florent Potvain, Joseph E. Coyle, Christopher William Murray, Philip J. Day, Valerio Berdini
Publikováno v:
Journal of Medicinal Chemistry. 59:5356-5367
Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was conducted against Lp-PLA2 in order to identify novel inhibitors. Multiple fragment hits were obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7919286100bbcfc9e76bca6023c7c4
https://doi.org/10.1021/acs.jmedchem.6b00212
https://doi.org/10.1021/acs.jmedchem.6b00212
Publikováno v:
SLAS DISCOVERY, 23 (9)
Native electrospray ionization mass spectrometry (ESI-MS) was applied to analyze the binding of compounds generated during fragment-based drug discovery (FBDD) campaigns against two functionally distinct proteins, the X-linked inhibitor of apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c51a249be203703dc77be3b311ff1d6
https://hdl.handle.net/20.500.11850/264345
https://hdl.handle.net/20.500.11850/264345
Autor:
Joseph E. Coyle, Finn P. Holding, Renato Zenobi, Agni F. M. Gavriilidou, Dmitry B. Veprintsev, Daniel Mayer
Publikováno v:
Biochemistry, 57 (11)
Biochemistry, 57 (11)
ISSN:0006-2960
ISSN:1520-4995
ISSN:0006-2960
ISSN:1520-4995
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97f108b4a7e7c0961bfe23ab1e8e189
Autor:
Lydia Y. W. Lee, Aman Iqbal, Sahil Patel, Gordon Saxty, Carr Maria Grazia, Valerio Berdini, Keisha Hearn, Ildiko Maria Buck, Christopher William Murray, Kirsten V. Smith, Anne Cleasby, Paul N. Mortenson, Vanessa Martins, Joseph E. Coyle, Jayne Curry, Joanne M. Munck, Phillip J. Day, Susan Roomans, James Edward Harvey Day, Emiliano Tamanini, Lee William Page
Publikováno v:
ACS Medicinal Chemistry Letters. 6:798-803
The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against DDR1 and identified fragments that bound either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cc4aabaaba0c23f9593552e8263dd9
https://doi.org/10.1021/acsmedchemlett.5b00143
https://doi.org/10.1021/acsmedchemlett.5b00143
Autor:
Christopher William Murray, Joseph E. Coyle, Sharna J. Rich, Anne Cleasby, Tracey Ann Sambrook, S. Saalau-Bethell, Jeff Yon, Valerio Berdini, Mladen Vinkovic, Victoria Lock, M. Alistair O’Brien, Miles Congreve, Harren Jhoti
Publikováno v:
'ChemMedChem ', vol: 9, pages: 823-832 (2014)
Chemmedchem
Chemmedchem
Soluble adenylate cyclases catalyse the synthesis of the second messenger cAMP through the cyclisation of ATP and are the only known enzymes to be directly activated by bicarbonate. Here, we report the first crystal structure of the human enzyme that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c763854d609cb5fa0221a0ecc011d10d
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:39648
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:39648
Autor:
Alison J-A, Woolford, Philip J, Day, Véronique, Bénéton, Valerio, Berdini, Joseph E, Coyle, Yann, Dudit, Pascal, Grondin, Pascal, Huet, Lydia Y W, Lee, Eric S, Manas, Rachel L, McMenamin, Christopher W, Murray, Lee W, Page, Vipulkumar K, Patel, Florent, Potvain, Sharna J, Rich, Yingxia, Sang, Don O, Somers, Lionel, Trottet, Zehong, Wan, Xiaomin, Zhang
Publikováno v:
Journal of medicinal chemistry. 59(23)
Lp-PLA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83fb82961d40486ce5b47401fdb5f2b6
https://pubmed.ncbi.nlm.nih.gov/27933945
https://pubmed.ncbi.nlm.nih.gov/27933945
The remarkable ability of the chaperonin GroEL to recognise a diverse range of non-native states of proteins constitutes one of the most fascinating molecular recognition events in protein chemistry. Recent structural studies have revealed a possible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8588d3498e014b85f8e365ccbd30799
https://ora.ox.ac.uk/objects/uuid:f9ee1b70-79e0-4c0e-8d64-ecd84e3e1231
https://ora.ox.ac.uk/objects/uuid:f9ee1b70-79e0-4c0e-8d64-ecd84e3e1231