Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph D. Paonessa"'
Autor:
Yun Li, Zhidan Chen, Joseph D. Paonessa, Walter Meinl, Arup Bhattacharya, Hansruedi Glatt, Paul Vouros, Yuesheng Zhang
Publikováno v:
Cancer Medicine, Vol 7, Iss 11, Pp 5604-5610 (2018)
Abstract Bladder cancer risk is 3‐4 times higher in men than women, but the reason is poorly understood. In mice, male bladder is also more susceptible than female bladder to 4‐aminobiphenyl (ABP), a major human bladder carcinogen; however, femal
Externí odkaz:
https://doaj.org/article/0bd0fa53678549dd93c5657143a196ac
Publikováno v:
Journal of Functional Foods, Vol 5, Iss 4, Pp 1996-2001 (2013)
Dietary isothiocyanates are a group of promising chemopreventive agents obtained primarily from cruciferous vegetables. Due to their potent chemopreventive and/or anti-cancer activities, there is a growing interest in assessing dietary isothiocyanate
Externí odkaz:
https://doaj.org/article/1acb3e12ca7945d18338ba791b29fc11
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35122 (2012)
NF-E2 related factor-2 (Nrf2) promotes the transcription of many cytoprotective genes and is a major drug target for prevention of cancer and other diseases. Indeed, the cancer-preventive activities of several well-known chemical agents were shown to
Externí odkaz:
https://doaj.org/article/7686f76406424919a655490b93b7f482
Autor:
Aimee Stablewski, Paul Vouros, Arup Bhattacharya, Yuesheng Zhang, Joseph D. Paonessa, Joshua J. Klaene, Yun Li
Publikováno v:
Oncotarget
Bladder cancer risk is significantly higher in men than in women. 4-Aminobiphenyl (ABP) is a major human bladder carcinogen from tobacco smoke and other sources. In mice, male bladder is more susceptible to ABP-induced carcinogenesis than female blad
Publikováno v:
Journal of Functional Foods, Vol 5, Iss 4, Pp 1996-2001 (2013)
Dietary isothiocyanates are a group of promising chemopreventive agents obtained primarily from cruciferous vegetables. Due to their potent chemopreventive and/or anti-cancer activities, there is a growing interest in assessing dietary isothiocyanate
Autor:
Paul Vouros, Joseph D. Paonessa, Yi Ding, Yuesheng Zhang, Dayana Argoti, Kristen L. Randall, Zachary Oaks
Publikováno v:
Journal of Chromatography A. 1217:4135-4143
Exposure to 4-aminobiphenyl (4-ABP), an environmental and tobacco smoke carcinogen that targets the bladder urothelium, leads to DNA adduct formation and cancer development [1]. Two major analytical challenges in DNA adduct analysis of human samples
Autor:
Yuesheng Zhang, Li Tang, Joseph D. Paonessa, Feng Geng, Yun Li, Shang Chiung Chen, Arup Bhattacharya, Michael K.K. Wong
Publikováno v:
Carcinogenesis. 31:281-286
Bladder cancer is one of the common human cancers and also has a very high recurrence rate. There is a great need for agents capable of inhibiting bladder cancer development and recurrence. Here, we report that allyl isothiocyanate (AITC), an ingredi
Autor:
Yuesheng Zhang, Christine M. Munday, Rex Munday, Paulette Mhawech-Fauceglia, Joseph D. Paonessa
Publikováno v:
Chemico-Biological Interactions. 180:119-126
It has been widely recognized that induction of Phase 2 enzymes is an effective and sufficient strategy for achieving protection against carcinogenesis. Nrf2 is the unifying master regulator of these enzymes and its activation in various tissues, inc
Autor:
Rex Munday, Yuesheng Zhang, Joseph D. Paonessa, Paul Vouros, Dayana Argoti, Kristen L. Randall, Yi Ding
Publikováno v:
Cancer research. 71(11)
NF-E2–related factor 2 (Nrf2) is a major cytoprotective gene and is a key chemopreventive target against cancer and other diseases. Here we show that Nrf2 faces a dilemma in defense against 4-aminobiphenyl (ABP), a major human bladder carcinogen fr
Autor:
Kristina L. Wade, Yuesheng Zhang, Arup Bhattacharya, Joseph D. Paonessa, Yun Li, Jed W. Fahey
Publikováno v:
Carcinogenesis. 31(12)
Allyl isothiocyanate (AITC), which occurs in many common cruciferous vegetables, was recently shown to be selectively delivered to bladder cancer tissues through urinary excretion and to inhibit bladder cancer development in rats. The present investi