Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Joseph D. Mosca"'
Autor:
Ernst Böhnlein, Kyle Hendricks, Linda N. Liu, Gang Wang, Joseph D. Mosca, Uwe Junker, Keunmyoung Lee
Publikováno v:
STEM CELLS Translational Medicine. 2:362-375
Rheumatoid arthritis (RA) is a systemic autoimmune disease with unknown etiology where tumor necrosis factor-α (TNFα) plays a critical role. Etanercept, a recombinant fusion protein of human soluble tumor necrosis factor receptor II (hsTNFR) linked
Autor:
Diana Buyaner, Ronald Hoffman, Mandy Siatskas, Wayne Hardy, Nadim Mahmud, Sheila Patil, Cord Sturgeon, Alastair Morgan Mackay, Karen Ferrer, Joseph D. Mosca, Mary Nelson, Annemarie Moseley, Robert J. Deans, Steven M. Devine, Amelia Bartholomew
Publikováno v:
Human Gene Therapy. 12:1527-1541
Human mesenchymal stem cells (MSCs) are capable of differentiating into multiple mesenchymal lineages including chondrocytes, osteocytes, adipocytes, and marrow stromal cells. Using a nonhuman primate model, we evaluated nonhuman primate MSCs as targ
Autor:
Mark F. Pittenger, Keunmyoung Lee, J.Kyle Hendricks, Joseph D. Mosca, Manas K. Majumdar, Diana Buyaner
Publikováno v:
Molecular Therapy. 3:857-866
Human adult bone marrow contains both hematopoietic stem cells that generate cells of all hematopoietic lineages and human mesenchymal stem cells (hMSCs), which support hematopoiesis and contribute to the regeneration of multiple connective tissues.
Autor:
Scott Weissman, Theodore D.K. Chung, Annemarie Moseley, Robert J. Deans, Sheila Patil, Cord Sturgeon, Steven M. Devine, Dorie Sher, Joseph D. Mosca, Mary Nelson, Karen Ferrer, Terry A. Hewett, Wendy Stock, Nadim Mahmud, Amelia Bartholomew, Ronald Hoffman, Wayne Hardy
Publikováno v:
Experimental Hematology. 29:244-255
Objective The human bone marrow contains mesenchymal stem cells capable of differentiating along multiple mesenchymal cell lineages. Using a non-human primate model, we sought to determine whether the systemic infusion of baboon-derived mesenchymal s
Autor:
Neelam Jaiswal, Scott P. Bruder, Sudha Kadiyala, Karl H. Kraus, Nancy S. Ricalton, Joseph D. Mosca
Publikováno v:
Clinical Orthopaedics and Related Research. :S247-S256
Bone marrow contains a population of rare progenitor cells capable of differentiating into bone, cartilage, muscle, tendon, and other connective tissues. These cells, referred to as MSCs, can be purified and culture expanded from animals and humans.
Publikováno v:
Journal of Cellular Physiology. 176:57-66
Mesenchymal stem cells (MSCs) are a population of pluripotent cells within the bone marrow microenvironment defined by their ability to differentiate into cells of the osteogenic, chondrogenic, tendonogenic, adipogenic, and myogenic lineages. We have
Autor:
Joseph D. Mosca, Z. Yu, J. H. Kim, Sumesh Kaushal, Liyanage P. Perera, Eric R. Hall, V. F. La Russa, S. W. Kessler, S. Gartner
Publikováno v:
Journal of Biomedical Science. 4:61-68
In order to develop a convenient small-animal model that can support the differentiation of human bone-marrow-derived CD34+ cells, we transplanted SCID mice with an immortalized human stromal cell line, Lof(11-10). The Lof(11-10) cell line has been c
Autor:
S Gartner, Jisoo Kim, Joseph D. Mosca, Pradeep N. Perera, Douglas L. Mayers, Julia Z. Xu, Thomas Reid, D St. Louis, Steven W. Kessler, David W. Ritchey, Zu-Xi Yu, S Kaushal, VF La Russa, S Perfetto
Publikováno v:
Blood. 88:130-137
The susceptibility of highly purified human CD34+ cells to monocytotropic (Ba-L) and lymphotropic (A018-post) strains of human immunodeficiency virus-1 (HIV-1) was examined. Liquid cultures initiated with fresh immunomagnetically purified CD34+ cells
Autor:
Ernst Böhnlein, Ivan Plavec, Sumesh Kaushal, Creton Kalfoglou, Joseph D. Mosca, Sonia Escaich
Publikováno v:
Human Gene Therapy. 6:625-634
Two clinical regimens have been proposed for gene therapies of acquired immunodeficiency syndrome (AIDS): (i) Genetic modification of differentiated peripheral mononuclear cells ex vivo and (ii) gene delivery into hematopoietic stem/progenitor cells
Publikováno v:
Journal of Virology. 69:476-491
A number of previous studies have implied that three herpes simplex virus-encoded nuclear transactivator proteins, IE175 (ICP4), IE110 (ICP0), and IE63 (ICP27), may cooperate in transcriptional and posttranscriptional stimulation of viral gene expres