Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joseph D. McMonagle"'
Publikováno v:
Drug and Chemical Toxicology. 45:2185-2192
Prolonged seizures are a hallmark feature of intoxication with anticholinesterase nerve agents such as soman. While benzodiazepine drugs are typically used to control these seizures, studies in both rats and guinea pigs have shown that potent, centra
Publikováno v:
International Journal of Toxicology. 37:352-363
Oxime reactivators are critical antidotes after organophosphate pesticide or nerve agent poisoning, directly restoring the function of inhibited acetylcholinesterase. In the continuing search for more broad-spectrum acetylcholinesterase reactivators,
Publikováno v:
Analytical Chemistry. 88:6523-6530
Several methods for the bioanalysis of nerve agents or their metabolites have been developed for the verification of nerve agent exposure. However, parent nerve agents and known metabolites are generally rapidly excreted from biological matrixes typi
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 104:27-34
This study evaluated the anticonvulsant effectiveness of midazolam to stop seizures elicited by the nerve agent soman when midazolam was administered by different routes (intramuscular, intranasal or sublingual) at one of two different times after th
Autor:
J.R. Keeler, J. R. Smith, M.A Carter, T. W. Dolzine, A Swift, F.R. Sidell, Joseph D. McMonagle, R.A Evans, E.M. Jakubowski
Publikováno v:
Toxicology Methods. 10:143-150
A case of accidental human exposure to sulfur mustard, the chemical warfare agent, was documented. The exposure produced skin damage in the form of erythema and blisters comprising less than 5% of the body surface area. Analytical methods verified an
Publikováno v:
Journal of Applied Toxicology. 14:195-199
This study reports on the pharmacokinetics of the elimination of the metabolites of three toxic organophosphorus compounds (soman, sarin and GF). Urine, blood and lung tissue were collected from rats dosed subcutaneously at 75 micrograms kg-1. Urinar
Publikováno v:
Drug and chemical toxicology. 33(3)
Near-lethal exposure to nerve agents produces prolonged epileptiform seizures requiring the administration of benzodiazepine anticonvulsant drugs, such as diazepam. Clinically, benzodiazepines are reported to lose anticonvulsant effectiveness the gre
Publikováno v:
Toxicology mechanisms and methods. 17(5)
This study determines soman toxicity in African green monkeys (Chlorocebus aethiops) and is the first step in exploring the suitability of this species as a model for nerve agent studies. Male African green monkeys were surgically implanted with tele
Publikováno v:
Biological Mass Spectrometry. 20:717-723
The major metabolites and breakdown products of some toxic organophosphonates are their respective alky-methylphosphonic acids. These acids ionize at physiological pH and are not amenable to gas chromatographic analysis in their underivatized forms.
Publikováno v:
Drug and chemical toxicology. 27(1)
This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus. Guinea pigs, implanted with cortical electroencephalographic (EEG) recording electrodes, were pretre