Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joseph D. Gardinier"'
Publikováno v:
Bone Reports, Vol 8, Iss , Pp 29-37 (2018)
Exercise is a key determinate of fracture risk and provides a clinical means to promote bone formation. However, the efficacy of exercise to increase bone mass declines with age. The purpose of this study was to identify age-related differences in th
Externí odkaz:
https://doaj.org/article/9ed69145eb374843bf9dc331d6335bde
Autor:
Nicholas J Chargo, Jonathan D Schepper, Naoimy Rios‐Arce, Ho Jun Kang, Joseph D Gardinier, Narayanan Parameswaran, Laura R McCabe
Publikováno v:
JBMR Plus, Vol 7, Iss 12, Pp n/a-n/a (2023)
ABSTRACT Glucocorticoids (GCs) are commonly used anti‐inflammatory medications with significant side effects, including glucocorticoid‐induced osteoporosis (GIO). We have previously demonstrated that chronic subcutaneous GC treatment in mice lead
Externí odkaz:
https://doaj.org/article/25d7a5965ca14fa3968fdeb4664b3415
Publikováno v:
Calcified Tissue International. 112:463-471
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211076 (2019)
Exercise and physical activity are critical to maintain bone mass and strength throughout life. Both exercise and physical activity subject bone to a unique combination of stimuli in the forms of dynamic loading and a systemic increase in parathyroid
Externí odkaz:
https://doaj.org/article/4d0fa538d6174282832a206ef4694ff4
Publikováno v:
J Cell Physiol
Age-related bone loss is attributed to the accumulation of senescent cells and their increasing production of inflammatory cytokines as part of the senescence-associated secretory phenotype (SASP). In otherwise healthy individuals, osteocytes play a
Autor:
Joseph D. Gardinier
Publikováno v:
Curr Osteoporos Rep
Adaptation to mechanical loading is critical to maintaining bone mass and offers therapeutic potential to preventing age-related bone loss and osteoporosis. However, increasing the duration of loading is met with "diminishing returns" as the anabolic
Autor:
Fraser L. Collins, Naiomy Deliz Rios-Arce, Jonathan D. Schepper, Laura R. McCabe, Sandi Raehtz, Narayanan Parameswaran, Robert A. Britton, Joseph D Gardinier, Laura Schaefer
Publikováno v:
Journal of Bone and Mineral Research. 34:681-698
Antibiotic treatment, commonly prescribed for bacterial infections, depletes and subsequently causes long-term alterations in intestinal microbiota composition. Knowing the importance of the microbiome in the regulation of bone density, we investigat
Publikováno v:
Bone. 117:130-137
The lacunar-canaliculi system is a network of channels that is created and maintained by osteocytes as they are embedded throughout cortical bone. As osteocytes modify their lacuna space, the local tissue composition and tissue strength are subject t
Autor:
Joseph D. Gardinier, Lauren Hurd, Victor M DeBarros, Nicholas Trompeter, Vimal Gangadharan, Mary E. Boggs, William Cain, Randall L. Duncan
Publikováno v:
Cell Calcium
Both mechanical and biochemical stimulation are required for maintaining the integrity of articular cartilage. However, chondrocytes respond differently to mechanical stimuli in osteoarthritic cartilage when biochemical signaling pathways, such as In
Autor:
Victor M DeBarros, Nicholas Trompeter, Vimal Gangadharan, Lauren Hurd, Mary E. Boggs, Randall L. Duncan, William Cain, Joseph D. Gardinier
Both mechanical and IGF-1 stimulation are required for normal articular cartilage development and maintenance of the extracellular matrix. While much effort has been made to define the signaling pathways associated with these anabolic stimuli, we foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5111150e57aeed8b66dae0b75e18eacb