Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Joseph D. Challenger"'
Autor:
Nicaise D. C. Djègbè, Dari F. Da, Bernard M. Somé, Lawata Inès G. Paré, Fatoumata Cissé, Wadaka Mamai, Karine Mouline, Simon P. Sawadogo, Joseph D. Challenger, Thomas S. Churcher, Roch K. Dabiré
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-10 (2024)
A bstract Background Anopheles mosquitoes are ectothermic and involved in numerous pathogen transmissions. Their life history traits are influenced by several environmental factors such as temperature, relative humidity and photoperiodicity. Despite
Externí odkaz:
https://doaj.org/article/fc2b499a0ee044eeb5f9e5d1ec7453e1
Autor:
Lucy C. Okell, Titus K. Kwambai, Aggrey Dhabangi, Carole Khairallah, Thandile Nkosi-Gondwe, Peter Winskill, Robert Opoka, Andria Mousa, Melf-Jakob Kühl, Tim C. D. Lucas, Joseph D. Challenger, Richard Idro, Daniel J. Weiss, Matthew Cairns, Feiko O. ter Kuile, Kamija Phiri, Bjarne Robberstad, Amani Thomas Mori
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Trial data have shown that post-discharge malaria chemoprevention (PDMC) reduces the risk of readmission and death in children previously hospitalised with severe malarial anaemia. Here, the authors use mathematical modelling to estimate the potentia
Externí odkaz:
https://doaj.org/article/2e8ada726ea542e781c5ff5867e0d38d
Autor:
Joseph D. Challenger, Rebecca K. Nash, Corine Ngufor, Antoine Sanou, K. Hyacinthe Toé, Sarah Moore, Patrick K. Tungu, Mark Rowland, Geraldine M. Foster, Raphael N’Guessan, Ellie Sherrard-Smith, Thomas S. Churcher
Publikováno v:
Current Research in Parasitology and Vector-Borne Diseases, Vol 3, Iss , Pp 100115- (2023)
Experimental hut trials (EHTs) are used to evaluate indoor vector control interventions against malaria vectors in a controlled setting. The level of variability present in the assay will influence whether a given study is well powered to answer the
Externí odkaz:
https://doaj.org/article/9ff18521794b45e782e4ccf242ae4810
Autor:
Joseph D. Challenger, Cher Y. Foo, Yue Wu, Ada W. C. Yan, Mahdi Moradi Marjaneh, Felicity Liew, Ryan S. Thwaites, Lucy C. Okell, Aubrey J. Cunnington
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Relationships between viral load, severity of illness, and transmissibility of virus are fundamental to understanding pathogenesis and devising better therapeutic and prevention strategies for COVID-19. Here we present within-host modelling
Externí odkaz:
https://doaj.org/article/36cf8f0e0cc8483b94a97df0da67611f
Autor:
Corine Ngufor, Josias Fagbohoun, Abel Agbevo, Hanafy Ismail, Joseph D. Challenger, Thomas S. Churcher, Mark Rowland
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background Pyrethroid-PBO nets were conditionally recommended for control of malaria transmitted by mosquitoes with oxidase-based pyrethroid-resistance based on epidemiological evidence of additional protective effect with Olyset Plus compar
Externí odkaz:
https://doaj.org/article/e998ef36dfdb45aaa740c19b187d3eaf
Autor:
Roos M. de Jong, Lisette Meerstein-Kessel, Dari F. Da, Sandrine Nsango, Joseph D. Challenger, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Elias Duarte, Noam Teyssier, Robert W. Sauerwein, Thomas S. Churcher, Roch K. Dabire, Isabelle Morlais, Emily Locke, Martijn A. Huynen, Teun Bousema, Matthijs M. Jore
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (
Externí odkaz:
https://doaj.org/article/852c3163e8664f10865e9f61f43db532
Autor:
Joseph D. Challenger, Daniela Olivera Mesa, Dari F. Da, R. Serge Yerbanga, Thierry Lefèvre, Anna Cohuet, Thomas S. Churcher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Malaria transmission-blocking vaccines are in development, but roll-out strategies have not been assessed. Here, the authors show that transmission-blocking activity is likely to be higher in the field than in laboratory conditions, and that school-a
Externí odkaz:
https://doaj.org/article/41ceb2127e404427bfbc8cb9e56a16c5
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020)
Abstract Background In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infectio
Externí odkaz:
https://doaj.org/article/237bb41b68cd46d2bb7a307b5ed97779
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Artemether lumefantrine is widely used for the treatment of uncomplicated malaria. The impact of imperfect patient adherence to the six-dose regimen is hard to assess. Using adherence data for unsupervised patients, the authors model how suboptimal a
Externí odkaz:
https://doaj.org/article/be1a2b6957f54156a4adac50845795aa
Autor:
Joseph D Challenger, Stijn W van Beek, Rob ter Heine, Saskia C van der Boor, Giovanni D Charles, Merel J Smit, Chris Ockenhouse, John J Aponte, Matthew B B McCall, Matthijs M Jore, Thomas S Churcher, Teun Bousema
Publikováno v:
The Journal of Infectious Diseases.
Transmission-blocking interventions can play an important role in combating malaria worldwide. Recently, a highly potent Plasmodium falciparum transmission-blocking monoclonal antibody (TB31F) was demonstrated to be safe and efficacious in malaria-na