Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Joseph D. Bauman"'
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Autor:
Steve Tuske, Jie Zheng, Erik D. Olson, Francesc X. Ruiz, Bruce D. Pascal, Anthony Hoang, Joseph D. Bauman, Kalyan Das, Jeffrey J. DeStefano, Karin Musier-Forsyth, Patrick R. Griffin, Eddy Arnold
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 116-129 (2020)
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pa
Externí odkaz:
https://doaj.org/article/7cba558dc6d74f5ca1cdc54c01017b4e
Autor:
Jerry Joe E. K. Harrison, Steve Tuske, Kalyan Das, Francesc X. Ruiz, Joseph D. Bauman, Paul L. Boyer, Jeffrey J. DeStefano, Stephen H. Hughes, Eddy Arnold
Publikováno v:
Viruses, Vol 13, Iss 8, p 1495 (2021)
In most cases, proteolytic processing of the retroviral Pol portion of the Gag-Pol polyprotein precursor produces protease (PR), reverse transcriptase (RT), and integrase (IN). However, foamy viruses (FVs) express Pol separately from Gag and, when Po
Externí odkaz:
https://doaj.org/article/d2a2429c574c4515b047df0567c30b54
Publikováno v:
IUCrJ, Vol 3, Iss 1, Pp 51-60 (2016)
Through X-ray crystallographic fragment screening, 4-bromopyrazole was discovered to be a `magic bullet' that is capable of binding at many of the ligand `hot spots' found in HIV-1 reverse transcriptase (RT). The binding locations can be in pockets t
Externí odkaz:
https://doaj.org/article/2a6c2b7457224809b3936de0fee335b4
Publikováno v:
Journal of Medicinal Chemistry. 66:6013-6024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07773d596b706bf9779145ce953a8c07
https://doi.org/10.1021/acs.jmedchem.2c01681
https://doi.org/10.1021/acs.jmedchem.2c01681
X-ray crystallographic fragment screening (XCFS) uses fragment-sized molecules (∼60 – 300 Da) to access binding sites on proteins that may be inaccessible to larger drug-like molecules (>300 Da). Previous studies from our lab and others have show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56764585fa027ce2e4e5e03d23980db
https://doi.org/10.1101/2022.10.17.512577
https://doi.org/10.1101/2022.10.17.512577
Autor:
Jerry Joe E. K. Harrison, Dario Oliveira Passos, Jessica F. Bruhn, Joseph D. Bauman, Lynda Tuberty, Jeffrey J. DeStefano, Francesc Xavier Ruiz, Dmitry Lyumkis, Eddy Arnold
Publikováno v:
Science Advances. 8
Key proteins of retroviruses and other RNA viruses are translated and subsequently processed from polyprotein precursors by the viral protease (PR). Processing of the HIV Gag-Pol polyprotein yields the HIV structural proteins and enzymes. Structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18ea0ba6f490ed8a245915c41dbe8ce
https://doi.org/10.1126/sciadv.abn9874
https://doi.org/10.1126/sciadv.abn9874
Autor:
Jie Zheng, Anthony Hoang, Steve Tuske, Kalyan Das, Erik D. Olson, Joseph D. Bauman, Bruce D. Pascal, Karin Musier-Forsyth, Eddy Arnold, Francesc X. Ruiz, Jeffrey J. DeStefano, Patrick R. Griffin
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss, Pp 116-129 (2020)
Current research in structural biology
Current research in structural biology
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a1736e5cfc877111f4c0ef68a8422d
http://www.sciencedirect.com/science/article/pii/S2665928X20300131
http://www.sciencedirect.com/science/article/pii/S2665928X20300131
Autor:
Luis Martinez-Sobrido, Aitor Nogales, Eddy Arnold, Joseph D. Bauman, Hye Yeon Sagong, Edmond J. LaVoie
Publikováno v:
ChemMedChem
Seasonal influenza infections are associated with an estimated 250-500 000 deaths annually. Resistance to the antiviral M2 ion-channel inhibitors has largely invalidated their clinical utility. Resistance to neuraminidase inhibitors has also been obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fb7ffd7803bdb83cf42f3ffc099ca1
https://pubmed.ncbi.nlm.nih.gov/30983160
https://pubmed.ncbi.nlm.nih.gov/30983160
Autor:
James R. Fuchs, Arthur J. Olson, Mamuka Kvaratskhelia, Stefano Forli, Lei Feng, Janet Antwi, D. Patel, Ronald M. Levy, Pratibha C. Koneru, Joseph D. Bauman, Erik Serrao, Nanjie Deng, Alan Engelman, Jacques J. Kessl, Eddy Arnold
Publikováno v:
Journal of Biological Chemistry. 291:23569-23577
HIV-1 integrase (IN) is essential for virus replication and represents an important multifunctional therapeutic target. Recently discovered quinoline-based allosteric IN inhibitors (ALLINIs) potently impair HIV-1 replication and are currently in clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9bfb32bbfe4818cb1bb991e7d9c8e8
https://doi.org/10.1074/jbc.m116.753384
https://doi.org/10.1074/jbc.m116.753384