Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Joseph D. Armstrong"'
Autor:
Grace P. Ahlqvist, Catherine P. McGeough, Chris Senanayake, Joseph D. Armstrong, Ajay Yadaw, Sarabindu Roy, Saeed Ahmad, David R. Snead, Timothy F. Jamison
Publikováno v:
ACS Omega, Vol 6, Iss 15, Pp 10396-10402 (2021)
Externí odkaz:
https://doaj.org/article/e106909195e0497984dd6bd8942615f4
Autor:
Sarabindu Roy, Ajay Yadaw, Subho Roy, Gopal Sirasani, Aravind Gangu, Jack D. Brown, Joseph D. Armstrong, Rodger W. Stringham, B. Frank Gupton, Chris H. Senanayake, David R. Snead
Publikováno v:
Organic Process Research & Development
Pyrrolo[2,1-f][1,2,4]triazine (1) is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound 1 was produced through a newly developed synthetic methodology utilizing simple building blocks such as pyrrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983e136e84bfddd6c883973d853a5823
http://europepmc.org/articles/PMC8787819
http://europepmc.org/articles/PMC8787819
Autor:
Ajay Yadaw, Saeed Ahmad, Grace P. Ahlqvist, Joseph D. Armstrong, Sarabindu Roy, Chris H. Senanayake, Catherine P. McGeough, Timothy F. Jamison, David R. Snead
Publikováno v:
ACS Omega, Vol 6, Iss 15, Pp 10396-10402 (2021)
ACS Omega
ACS Omega
Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d446c4710171dfaacbbff36a29d09d35
https://doi.org/10.1021/acsomega.1c00772
https://doi.org/10.1021/acsomega.1c00772
Autor:
Joseph D. Armstrong, Sarabindu Roy, Ajay Yadaw, Chris H. Senanayake, B. Frank Gupton, Gopal Sirasani, Subho Roy, David R. Snead
Pyrrolo[2,1-f][1,2,4]triazine (1) is an important regulatory starting material in the production of Remdesivir (Veklury®). Compound 1 was produced through a newly developed synthetic methodology utilizing the simple building blocks pyrrole, chlorami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1255dd5b9e457664fde4c686f78ead6f
https://doi.org/10.26434/chemrxiv.14109650.v1
https://doi.org/10.26434/chemrxiv.14109650.v1
Autor:
Tim Jamison, David R. Snead, Saeed Ahmad, Sarabindu Roy, Ajay Yadaw, Joseph D. Armstrong, Chris Senanayake, Catherine P. McGeough, Grace P. Ahlqvist
Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for treatment of COVID-19. Herein we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d030c7fd413a5fb633332565ceb7bfd
https://doi.org/10.26434/chemrxiv.13809527.v1
https://doi.org/10.26434/chemrxiv.13809527.v1
Autor:
Jaume Balsells, Edward J. J. Grabowski, Shane W. Krska, Nelo R. Rivera, Yongkui Sun, Joseph D. Armstrong, Bryon Simmons, Andrew M. Clausen, Felix Spindler, Yi Hsiao, Michele Kubryk, Christophe Malan, Karl B. Hansen, Nori Ikemoto, Feng Xu, Thorsten Rosner
Publikováno v:
Journal of the American Chemical Society. 142:13622-13622
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff28a025888c0453761a46c2fa910f8b
https://doi.org/10.1021/jacs.0c06041
https://doi.org/10.1021/jacs.0c06041
Autor:
Edward C. Sherer, Zhen Li, Daniel Zewge, Gabor Butora, Ian W. Davies, Joseph D. Armstrong, Greg Copeland, David M. Tellers, Joseph R. Gouker, Daniel R. Sidler, Vasant Jadhav
Publikováno v:
Bioconjugate chemistry. 29(6)
An efficient multicomponent orthogonal protocol was developed for post-synthetic oligonucleotide modification using commercially available 2'- O-methyl ester and 2'- O-propargyl nucleoside scaffolds. Amidation of methyl esters with primary amines was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36334fa0cc0b41aa5749ac2eaf41872
https://pubmed.ncbi.nlm.nih.gov/29893553
https://pubmed.ncbi.nlm.nih.gov/29893553
Publikováno v:
The Journal of Organic Chemistry. 71:840-843
[reaction: see text] Very practical synthesis of ephedrine analogues in high yields and enantiopurity was realized by a highly diastereoselective Meerwein-Ponndorf-Verley (MPV) reduction of protected alpha-amino aromatic ketones using catalytic alumi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549c3473d6d02683c04588992d162243
https://doi.org/10.1021/jo052121t
https://doi.org/10.1021/jo052121t
Publikováno v:
Organic Letters. 7:4935-4938
[reaction: see text] The catalytic asymmetric hydrogenation of enamine amides and esters with catalyst Rh-1a, prepared from ferrocenyl based ligand 1a or 1b and [(COD)RhCl](2), has been shown through kinetic studies to suffer from product inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b17c299eb22a773fca8fa5a103f364f
https://doi.org/10.1021/ol051862d
https://doi.org/10.1021/ol051862d
Autor:
Karl B. Hansen, Jaume Balsells, David Askin, Yi Hsiao, Nelo R. Rivera, Dietrich Steinhuebel, Edward J. J. Grabowski, Joseph D. Armstrong, Spencer D. Dreher, Michele Kubryk, Michael Palucki
Publikováno v:
Organic Process Research & Development. 9:634-639
A new synthesis of sitagliptin (MK-0431), a DPP-IV inhibitor and potential new treatment for type II diabetes, suitable for the preparation of multi-kilogram quantities is presented. The triazolopyrazine fragment of sitagliptin was prepared in 26% yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca80d63371c1a07b20959784f248863b
https://doi.org/10.1021/op0500786
https://doi.org/10.1021/op0500786