Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joseph D. Manna"'
Autor:
Eric Haines, Michael Burke, Rachel Catterall, Victor De Jesus, Bin Li, Joseph D. Manna, George Punkosdy, Oksana Zavidij, Sarah R. Wessel, Grace Werosta, Jill Cavanaugh, Sheila Newhouse, Aravind Basavapathruni, Lan Xu, Sergio Santillana, X. Michelle Zhang, Sabine K. Ruppel
Publikováno v:
Molecular Cancer Research. 21:PR10-PR10
Alterations in the RAS/RAF/MEK/ERK pathway are the most common drivers of oncogenesis. Although MEK is a clinically validated cancer target and several MEK inhibitors have been approved by the FDA, their clinical utility is limited to BRAFV600 mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f2462c249dd35c7b1ef3c0266b05ea
https://doi.org/10.1158/1557-3125.ras23-pr10
https://doi.org/10.1158/1557-3125.ras23-pr10
Publikováno v:
Bioanalysis. 9:359-368
Aim: Increasing numbers of compounds requiring stability data means highly optimized methods capable of rapid turnaround are desirable during early discovery. Materials and methods/results: An advanced, generic analytical workflow for metabolic stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8326a0475b7a4f93237e5ffb055a938
https://doi.org/10.4155/bio-2016-0187
https://doi.org/10.4155/bio-2016-0187
Autor:
Joseph D. Manna, Jae Won Chang, James A. Wepy, Lawrence J. Marnett, Benjamin F. Cravatt, Kenneth Hsu
Publikováno v:
Journal of Biological Chemistry. 289:33741-33753
Prostaglandin glycerol esters (PG-Gs) are produced as a result of the oxygenation of the endocannabinoid, 2-arachidonoylglycerol, by cyclooxygenase 2. Understanding the role that PG-Gs play in a biological setting has been difficult because of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b331c410d1175ef4d5c0c590604a78
https://doi.org/10.1074/jbc.m114.582353
https://doi.org/10.1074/jbc.m114.582353
Autor:
Joi Dunbar, Margaret A. Read, Joseph D. Manna, Alexander Constan, Alfredo C. Castro, Sherri Smith, Gordon Loewen, John Lee, Somarajan J. Nair, Jennifer Hoyt, Martin R. Tremblay, Julian Adams, Jeanne A. Ferguson, Jens Sydor, Veronica Campbell, Matthew Campbell, Karen McGovern, Brendan Arsenault, Marisa O. Peluso, Jylle Nevejans, Vito J. Palombella, Nigel Whitebread, Grogan Michael John, Kerrie Faia, John Soglia, Bennett Carter
Publikováno v:
Xenobiotica. 43:875-885
1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926 is low in mouse and dog and moderate in monkey. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50620a2c18fbef25785c49cf6a0c9deb
https://doi.org/10.3109/00498254.2013.780671
https://doi.org/10.3109/00498254.2013.780671
Autor:
Joseph D. Manna, Ned A. Porter, Kristie L. Rose, Christopher D. Aluise, Lawrence J. Marnett, Michelle L. Reyzer, Keri A. Tallman, Mariana Boiani
Publikováno v:
Chemical Research in Toxicology
Oxidation of membrane phospholipids is associated with inflammation, neurodegenerative disease, and cancer. Oxyradical damage to phospholipids results in the production of reactive aldehydes that adduct proteins and modulate their function. 4-Hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b49de6c0588473cf9a02d0020f33eb
http://europepmc.org/articles/PMC3579456
http://europepmc.org/articles/PMC3579456
Autor:
Joseph D. Manna, Richard M. Caprioli, Lawrence J. Marnett, Michelle L. Reyzer, C. David Weaver, Joey C. Latham
Publikováno v:
Analytical Chemistry. 83:6683-6688
Analysis and quantification of analytes in biological systems is a critical component of metabolomic investigations of cell function. The most widely used methods employ chromatographic separation followed by mass spectrometric analysis, which requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec20bc6fff78b04166fb9edd8c301d5
https://doi.org/10.1021/ac201224n
https://doi.org/10.1021/ac201224n
Autor:
Matthew Campbell, Eddy Tan, Kerry White, Vito J. Palombella, Julian Adams, James M. Conley, Jennifer Hoyt, Martin R. Tremblay, Margit Hagel, Jens Sydor, Jeanne A. Ferguson, Jill Cushing, Alfredo C. Castro, Somarajan J. Nair, Andre Lescarbeau, Melissa Pink, Joseph D. Manna, Grogan Michael John, Margaret A. Read, Caroline N. Woodward, Grace Lin, Mark L. Behnke, Teresa M. Alvarez-Diez, Michael Curtis, Lin-Chen Yu, John R. MacDougall, Karen McGovern, Brian C. Austad
Publikováno v:
Journal of medicinal chemistry. 52(14)
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2605d8d446344a594f8572549b6a22f4
https://pubmed.ncbi.nlm.nih.gov/19522463
https://pubmed.ncbi.nlm.nih.gov/19522463
Autor:
Martin R. Tremblay, André Lescarbeau, Michael J. Grogan, Eddy Tan, Grace Lin, Brian C. Austad, Lin-Chen Yu, Mark L. Behnke, Somarajan J. Nair, Margit Hagel, Kerry White, James Conley, Joseph D. Manna, Teresa M. Alvarez-Diez, Jennifer Hoyt, Caroline N. Woodward, Jens R. Sydor, Melissa Pink, John MacDougall, Matthew J. Campbell
Publikováno v:
Journal of Medicinal Chemistry; Jul2009, Vol. 52 Issue 14, p4400-4418, 19p