Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph D Trimarco"'
TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.
Autor:
Joseph D Trimarco, Brook E Heaton, Ryan R Chaparian, Kaitlyn N Burke, Raquel A Binder, Gregory C Gray, Clare M Smith, Vineet D Menachery, Nicholas S Heaton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009599 (2021)
Antiviral therapeutics are a front-line defense against virally induced diseases. Because viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in targeting the host proteins that the virus must co-opt to complete
Externí odkaz:
https://doaj.org/article/485cd3cfaf524a5b9fa4517614d1a44a
Autor:
Steven T Bruckbauer, Joseph D Trimarco, Camille Henry, Elizabeth A Wood, John R Battista, Michael M Cox
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0199482 (2019)
We have previously generated four replicate populations of ionizing radiation (IR)-resistant Escherichia coli though directed evolution. Sequencing of isolates from these populations revealed that mutations affecting DNA repair (through DNA double-st
Externí odkaz:
https://doaj.org/article/ff347e7d90bf460bb07b1e670a1e3473
Autor:
Joseph D. Trimarco, Sarah L. Nelson, Ryan R. Chaparian, Alexandra I. Wells, Nathan B. Murray, Parastoo Azadi, Carolyn B. Coyne, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of host antiviral restriction factors could provide targets for antiviral therapy. Here, using a genome-wide CRISPR screen, the authors identify the glycosyltransferase B3GAT1 as a host protein which, when ectopically overexpressed, re
Externí odkaz:
https://doaj.org/article/421acf3c2de24f58bda9a6d24454f5bd
Autor:
Jonathan P. Kastan, Martine W. Tremblay, Michael C. Brown, Joseph D. Trimarco, Elena Y. Dobrikova, Mikhail I. Dobrikov, Matthias Gromeier
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
It is believed that ∼7,000 messenger RNAs (mRNAs) are subject to N6
Externí odkaz:
https://doaj.org/article/eba075ab535042b3a16853b5e2479596
Autor:
Steven T. Bruckbauer, Joel Martin, Benjamin B. Minkoff, Mike T. Veling, Illissa Lancaster, Jessica Liu, Joseph D. Trimarco, Brian Bushnell, Anna Lipzen, Elizabeth A. Wood, Michael R. Sussman, Christa Pennacchio, Michael M. Cox
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Ionizing radiation (IR) is lethal to most organisms at high doses, damaging every cellular macromolecule via induction of reactive oxygen species (ROS). Utilizing experimental evolution and continuing previous work, we have generated the most IR-resi
Externí odkaz:
https://doaj.org/article/a410f6fccd354099aa01f6365d29842c
Autor:
Tomer M. Yaron, Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, Ting-Yu Lin, Katarina M. Liberatore, Danielle K. Bulaon, Samantha J. Van Nest, Nikos Koundouros, Edward R. Kastenhuber, Marisa N. Mercadante, Kripa Shobana-Ganesh, Long He, Robert E. Schwartz, Shuibing Chen, Harel Weinstein, Olivier Elemento, Elena Piskounova, Benjamin E. Nilsson-Payant, Gina Lee, Joseph D. Trimarco, Kaitlyn N. Burke, Cait E. Hamele, Ryan R. Chaparian, Alfred T. Harding, Aleksandra Tata, Xinyu Zhu, Purushothama Rao Tata, Clare M. Smith, Anthony P. Possemato, Sasha L. Tkachev, Peter V. Hornbeck, Sean A. Beausoleil, Shankara K. Anand, François Aguet, Gad Getz, Andrew D. Davidson, Kate Heesom, Maia Kavanagh-Williamson, David A. Matthews, Benjamin R. tenOever, Lewis C. Cantley, John Blenis, Nicholas S. Heaton
Publikováno v:
Science signaling, vol 15, iss 757
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f52febef82f67d02ed9c0d55e48f84
https://escholarship.org/uc/item/44d513nc
https://escholarship.org/uc/item/44d513nc
Autor:
Xinyu Zhu, Joseph D. Trimarco, Courtney A. Williams, Alejandro Barrera, Timothy E. Reddy, Nicholas S. Heaton
Publikováno v:
Cell reports. 41(4)
The cellular fate after infection with human coronaviruses (HCoVs) is typically death. Previous data suggest, however, that the transcriptional state of an individual cell may sometimes allow additional outcomes of infection. Here, to probe the range
Autor:
Joseph D Trimarco, Nicholas S Heaton
Publikováno v:
Curr Opin Virol
Influenza viruses are simultaneously supported and antagonized by factors within the host cell. This close relationship is the theoretical basis for future antivirals that target the host rather than the virus itself, a concept termed host-directed t
Autor:
Mikhail I. Dobrikov, Joseph D. Trimarco, Michael C. Brown, Martine W. Tremblay, Elena Y. Dobrikova, Matthias Gromeier, Jonathan P. Kastan
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
mBio
mBio
It is believed that ∼7,000 messenger RNAs (mRNAs) are subject to N6-methyladenosine modification. The biological significance of this remains mysterious.
Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host
Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host
SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2
Autor:
Shankara Anand, Lewis C. Cantley, Long He, Joseph D. Trimarco, Benjamin E. Nilsson-Payant, Edward R. Kastenhuber, Harel Weinstein, Andrew D. Davidson, Maia Kavanagh-Williamson, Elena Piskounova, Anthony Possemato, Tyler Levy, Cait E. Hamele, Xinyu Zhu, Robert E. Schwartz, Benjamin R. tenOever, Kaitlyn N. Burke, John Blenis, Jared L. Johnson, Gina Lee, Kripa Shobana-Ganesh, François Aguet, Sasha Tkachev, Gad Getz, David A. Matthews, Clare M. Smith, Kate J. Heesom, Nicholas S. Heaton, Purushothama Rao Tata, Shuibing Chen, Danielle K. Bulaon, Aleksandra Tata, Ryan R. Chaparian, Peter Hornbeck, Alexander Kerelsky, Katarina M. Liberatore, Tomer M. Yaron, Brook E. Heaton, Marisa N. Mercadante, Benjamin M. Cohen, Alfred T. Harding, Olivier Elemento, Sean A. Beausoleil, Ting-Yu Lin, Tristan X. Jordan
Publikováno v:
bioRxiv
While vaccines are vital for preventing COVID-19 infections, it is critical to develop new therapies to treat patients who become infected. Pharmacological targeting of a host factor required for viral replication can suppress viral spread with a low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8def4c82dbd399ebda8cd6b0c2c056c
https://europepmc.org/articles/PMC7430567/
https://europepmc.org/articles/PMC7430567/