Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Joseph D Dougherty"'
Autor:
Robert D Graham, Lisa Z Fang, Jessica R Tooley, Vani Kalyanaraman, Mary Christine Stander, Darshan Sapkota, Michelle R Lynch, Joseph D Dougherty, Bryan A Copits, Meaghan C Creed
Publikováno v:
Addiction Neuroscience, Vol 12, Iss , Pp 100170- (2024)
The ventral pallidum (VP) has emerged as a critical node in the mesolimbic reward system. Modulating the VP can impact the subjective valuation of rewards, reward motivation, and reward seeking under conflict, making it an attractive target for clini
Externí odkaz:
https://doaj.org/article/7d27ac6f204e4165bd5f120771d6659e
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 10 (2016)
Mice produce ultrasonic vocalizations (USV) in multiple communicative contexts, including adult social interaction (e.g., male to female courtship), as well as pup calls when separated from the dam. Assessment of pup USV has been widely applied in mo
Externí odkaz:
https://doaj.org/article/03150f49b89c4530953c61063e9101e7
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
The substantial progress in the last few years towards uncovering genetic causes and risk factors for autism spectrum disorders (ASD) has opened new experimental avenues for identifying the underlying neurobiological mechanism of the condition. The b
Externí odkaz:
https://doaj.org/article/1df48386eaf24453ae633a4632b8c5c6
Autor:
Tomas Lagunas, Stephen P. Plassmeyer, Anthony D. Fischer, Ryan Z. Friedman, Michael A. Rieger, Din Selmanovic, Simona Sarafinovska, Yvette K. Sol, Michael J. Kasper, Stuart B. Fass, Alessandra F. Aguilar Lucero, Joon-Yong An, Stephan J. Sanders, Barak A. Cohen, Joseph D. Dougherty
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively
Externí odkaz:
https://doaj.org/article/1be3cfd23894463dbf386a6bfd6edefd
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40511 (2012)
A major barrier to complex experimental design in mouse genetics is the allele problem: combining three or more alleles is time-consuming and inefficient. Here, we solve this problem for transgenic animals with a simple modification of existing BAC t
Externí odkaz:
https://doaj.org/article/ccb83502e28340a3b8a5351691fae712
Autor:
Elena I Fomchenko, Joseph D Dougherty, Karim Y Helmy, Amanda M Katz, Alexander Pietras, Cameron Brennan, Jason T Huse, Ana Milosevic, Eric C Holland
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e20605 (2011)
BackgroundGliomas are thought to form by clonal expansion from a single cell-of-origin, and progression-associated mutations to occur in its progeny cells. Glioma progression is associated with elevated growth factor signaling and loss of function of
Externí odkaz:
https://doaj.org/article/95d7ded787264c348290c92103d44730
Autor:
Diana C. Beard, Xiyun Zhang, Dennis Y. Wu, Jenna R. Martin, Alyssa Erickson, Jane Valeriane Boua, Nicole Hamagami, Raylynn G. Swift, Katherine B. McCullough, Xia Ge, Austin Bell-Hensley, Hongjun Zheng, Cory W. Palmer, Nicole A. Fuhler, Austin B. Lawrence, Cheryl A. Hill, Thomas Papouin, Kevin K. Noguchi, Audrey McAlinden, Joel R. Garbow, Joseph D. Dougherty, Susan E. Maloney, Harrison W. Gabel
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113411- (2023)
Summary: Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from differential severity of variants underlying disease, but how distinct alleles drive variable disease presentation is not well understood. Here, we investigate
Externí odkaz:
https://doaj.org/article/48fc308841a24ec68b568d4410c3c83e
Autor:
Shayna M. Mueller, Kelli McFarland White, Stuart B. Fass, Siyu Chen, Zhan Shi, Xia Ge, John A. Engelbach, Seana H. Gaines, Annie R. Bice, Michael J. Vasek, Joel R. Garbow, Joseph P. Culver, Zila Martinez-Lozada, Martine Cohen-Salmon, Joseph D. Dougherty, Darshan Sapkota
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Aquaporin-4 (AQP4) is a water channel protein that links the astrocytic endfeet to the blood-brain barrier (BBB) and regulates water and potassium homeostasis in the brain, as well as the glymphatic clearance of waste products that would otherwise po
Externí odkaz:
https://doaj.org/article/23246d79a9ba4d7b8bb5dd36fd714df5
Autor:
Claire Weichselbaum, Nicole Hendrix, Jordan Albright, Joseph D. Dougherty, Kelly N. Botteron, John N. Constantino, Natasha Marrus
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background A central challenge in preclinical research investigating the biology of autism spectrum disorder (ASD) is the translation of ASD-related social phenotypes across humans and animal models. Social orienting, an observable, evolutio
Externí odkaz:
https://doaj.org/article/bdcfc55a785e4ce88b5bbbba342b922d
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Large scale human genetic studies have shown that loss of function (LoF) mutations in MYT1L are implicated in neurodevelopmental disorders (NDDs). Here, we provide an overview of the growing number of published MYT1L patient cases, and summa
Externí odkaz:
https://doaj.org/article/6145959c23c04fbbae9e11a3b86759b8