Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Joseph D Dekker"'
Autor:
Alessandra Machado Araujo, Joseph D Dekker, Kendra Garrison, Zhe Su, Catherine Rhee, Zicheng Hu, Bum-Kyu Lee, Daniel Osorio, Jiwon Lee, Vishwanath R Iyer, Lauren IR Ehrlich, George Georgiou, Gregory Ippolito, Stephen Yi, Haley O Tucker
Publikováno v:
eLife, Vol 13 (2024)
We identified a novel mouse plasmacytoid dendritic cell (pDC) lineage derived from the common lymphoid progenitors (CLPs) that is dependent on expression of Bcl11a. These CLP-derived pDCs, which we refer to as ‘B-pDCs’, have a unique gene express
Externí odkaz:
https://doaj.org/article/80e19280b37e44668886ed8fca1eecca
Autor:
Garrett L. Cornelison, Ileana Pedraza, Kendra Garrison, Elizabeth M. Kapeel, Channing Pletka, Abdul Khan, Jessica Momb, Rebecca Martin, Adam Bartos, Joseph D. Dekker, Jay Zhao, John Majercak, Garrett L. Robinson
Publikováno v:
Cancer Research. 83:P4-08
Engineered Toxin Bodies Specific for TROP2 Positive Cancers Authors: Garrett L. Cornelison, Ileana Pedraza, Kendra Garrison, Elizabeth M. Kapeel, Channing Pletka, Abdul Khan, Jessica Momb, Rebecca Martin, Adam Bartos, Joseph D. Dekker, Jay Zhao, John
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41848d10fe5100e4f2a8781c7f5b4dee
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-18
https://doi.org/10.1158/1538-7445.sabcs22-p4-08-18
Autor:
Caroline Alayne Pearson, Destaye M. Moore, Haley O. Tucker, Joseph D. Dekker, Hui Hu, Amaya Miquelajáuregui, Bennett G. Novitch
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1964-1981.e3 (2020)
Summary: The laminar architecture of the mammalian neocortex depends on the orderly generation of distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. Here, we identify critical roles for the autism risk gene Foxp1 in maintain
Externí odkaz:
https://doaj.org/article/2bb491ebc4e24fe5ba78d5df2fae100a
Autor:
Melissa Popowski, Troy D. Templeton, Bum-Kyu Lee, Catherine Rhee, He Li, Cathrine Miner, Joseph D. Dekker, Shari Orlanski, Yehudit Bergman, Vishwanath R. Iyer, Carol F. Webb, Haley Tucker
Publikováno v:
Stem Cell Reports, Vol 2, Iss 1, Pp 26-35 (2014)
We show here that singular loss of the Bright/Arid3A transcription factor leads to reprograming of mouse embryonic fibroblasts (MEFs) and enhancement of standard four-factor (4F) reprogramming. Bright-deficient MEFs bypass senescence and, under stand
Externí odkaz:
https://doaj.org/article/4a81e6e80a0c47439d7ef2ef89fe7aa7
Autor:
Garrett L. Cornelison, Adam Bartos, Brigitte Brieschke, Jessica Momb, Ileana Pedraza, Elizabeth M. Kapeel, Rebecca Martin, Channing Pletka, Adrian Gonzalez, Joseph D. Dekker, Jay Zhao, John Majercak, Garrett L. Robinson
Publikováno v:
Cancer Research. 82:326-326
Engineered toxin bodies (ETBs) are comprised of a proprietarily engineered form of Shiga-like Toxin A subunit (SLT-A) genetically fused to antibody-like binding domains. ETBs work through novel mechanisms of action and are capable of forced internali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f2fe9c76ae838b6b9164c80a0f1ce5
https://doi.org/10.1158/1538-7445.am2022-326
https://doi.org/10.1158/1538-7445.am2022-326
Autor:
Swati Khanna, Elizabeth M. Kapeel, Lauren R. Byrne, Elizabeth Saputra, Steven Rivera, Lindsey Aschenbach, Lilia A. Rabia, Garrett L. Cornelison, Rachael M. Orlandella, Brigitte Brieschke, Michaela Sousares, Jay Zhao, Garrett L. Robinson, Chris Moore, Joseph D. Dekker
Publikováno v:
Cancer Research. 82:3543-3543
Targeting of PD-L1 checkpoint has shown clinical efficacy in multiple solid tumor indications. Currently approved PD-L1 targeted approaches rely on the blocking activity of monoclonal antibodies (mAbs) which sterically inhibit PD-L1 thus preventing P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c2dbc19c675d76e5455c7b7a21f5cb7
https://doi.org/10.1158/1538-7445.am2022-3543
https://doi.org/10.1158/1538-7445.am2022-3543
Autor:
Rachael M. Orlandella, Elizabeth M. Kapeel, Brigitte Brieschke, Garrett L. Robinson, Joseph D. Dekker, Chris B. Moore
Publikováno v:
Cancer Research. 82:2579-2579
Engineered Toxin Bodies (ETBs) represent a unique therapeutic strategy for fighting cancer by targeting and selectively destroying cancer cells or cancer-promoting immune cells. Featuring an antibody-based targeting domain fused with the cytotoxic, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3fff8b659798cf01b12c7413b267c6
https://doi.org/10.1158/1538-7445.am2022-2579
https://doi.org/10.1158/1538-7445.am2022-2579
Autor:
Caleigh Howard, Shu Wiley, Wenzhao Dong, Andrea Mendiola, Veronica Partridge, Sara LeMar, Paul Amador, Amit K. Chaudhary, Joseph D. Dekker, Jay Zhao, Ross Durland, Aimee Iberg
Publikováno v:
Cancer Research. 82:335-335
Engineered toxin bodies (ETBs) are next-generation immunotoxins that harbor an antibody-derived targeting domain and a cytotoxic payload derived from Shiga-like toxin-1 catalytic subunit A (SLTA). SLTA has been engineered to reduce innate immunogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48bf0f44bbe00d6e794c14f27458ec55
https://doi.org/10.1158/1538-7445.am2022-335
https://doi.org/10.1158/1538-7445.am2022-335
Autor:
Joseph D. Dekker, Melissa A. Edwards, Huimin Geng, Mark A. Brown, Haley O. Tucker, Ilham Alshiraihi
Publikováno v:
Genes and immunity, vol 21, iss 2
Genes and immunity
Genes and immunity
The five membered SET and MYND Domain-containing lysine methyltransferase (SMYD) family plays pivotal roles in development and proliferation. Initially characterized within the cardiovascular system, one such member, SMYD2, has been implicated as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8837e22505fb5dbc50d79cf6ae98c1c0
https://doi.org/10.1038/s41435-020-0094-8
https://doi.org/10.1038/s41435-020-0094-8
Autor:
Tara L Rasmussen, Yanlin Ma, Chong Yon Park, June Harriss, Stephanie A Pierce, Joseph D Dekker, Nicolas Valenzuela, Deepak Srivastava, Robert J Schwartz, M David Stewart, Haley O Tucker
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121765 (2015)
Smyd1/Bop is an evolutionary conserved histone methyltransferase previously shown by conventional knockout to be critical for embryonic heart development. To further explore the mechanism(s) in a cell autonomous context, we conditionally ablated Smyd
Externí odkaz:
https://doaj.org/article/6474b35f28774de6a4df747fea3aeed0