Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joseph D Barry"'
Autor:
Megha Subramanian, James McIninch, Ivan Zlatev, Mark K. Schlegel, Charalambos Kaittanis, Tuyen Nguyen, Saket Agarwal, Timothy Racie, Martha Arbaiza Alvarado, Kelly Wassarman, Thomas S. Collins, Tyler Chickering, Christopher R. Brown, Karyn Schmidt, Adam B. Castoreno, Svetlana Shulga-Morskaya, Elena Stamenova, Kira Buckowing, Daniel Berman, Joseph D. Barry, Anna Bisbe, Martin A. Maier, Kevin Fitzgerald, Vasant Jadhav
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.
Externí odkaz:
https://doaj.org/article/0fc8fb8623c24daabbd0601f2495d2bc
Autor:
Joseph D. Barry, Maud Fagny, Joseph N. Paulson, Hugo J.W.L. Aerts, John Platig, John Quackenbush
Publikováno v:
iScience, Vol 5, Iss , Pp 80-89 (2018)
Summary: Genotype-to-phenotype association studies typically use macroscopic physiological measurements or molecular readouts as quantitative traits. There are comparatively few suitable quantitative traits available between cell and tissue length sc
Externí odkaz:
https://doaj.org/article/f0bffe5eb0ef4f57bf0249df0c9d5706
Autor:
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
Publikováno v:
Nucleic acids research. 50(12)
Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target effects as a major driver of hepatotoxicity for GalNAc–siRNA conjugates. Here, we demonstrate that a single glycol nucleic acid or 2′–5′-RNA modificatio
Autor:
Yesseinia I. Anglero-Rodriguez, Florian A. Lempp, James McIninch, Mark K. Schlegel, Christopher R. Brown, Donald J. Foster, Adam B. Castoreno, Tuyen Nguyen, Megha Subramanian, Martin Montiel-Ruiz, Hannah Kaiser, Anna Sahakyan, Roberto Spreafico, Svetlana Shulga Morskaya, Joseph D. Barry, Daniel Berman, Stephanie Lefebvre, Anne Kasper, Timothy Racie, Diann Weddle, Melissa Mobley, Arlin Rogers, Joseph Dybowski, Saeho Chong, Jayaprakash Nair, Amy Simon, Kevin Sloan, Seungmin Hwang, Herbert W. Virgin, Kevin Fitzgerald, Martin A. Maier, Gregory Hinkle, Christy M. Hebner, Akin Akinc, Vasant Jadhav
RNA interference is a natural antiviral mechanism that could be harnessed to combat SARS-CoV-2 infection by targeting and destroying the viral genome. We screened lipophilic small-interfering RNA (siRNA) conjugates targeting highly conserved regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd2ebe031d135cd9e0bfc23cecf5156
https://doi.org/10.1101/2022.03.20.485044
https://doi.org/10.1101/2022.03.20.485044
Autor:
John Szeto, Adam Castoreno, Muthiah Manoharan, Daniel Berman, Sally Schofield, Klaus Charisse, Christopher R. Brown, Shigeo Matsuda, Joel M. Harp, Mark K Schlegel, Joseph D. Barry, Martin Maier, Martin Egli
Publikováno v:
Nucleic Acids Research
We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc–siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a s
Autor:
Joseph D. Barry, Kevin Fitzgerald, Greg Hinkle, Sarah Solomon, Svetlana Shulga Morskaya, Tuyen Nguyen, Stuart Milstein
Publikováno v:
BCB
RNAi therapeutics can be designed to silence almost any gene of interest and have demonstrated high levels of efficacy and acceptable safety profiles in pre-clinical and clinical development for cardio-metabolic, hepatic infectious, central nervous s