Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Joseph D, Zak"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Sensory systems are organized hierarchically, but feedback projections frequently disrupt this order. In the olfactory bulb (OB), cortical feedback projections numerically match sensory inputs. To unravel information carried by these two str
Externí odkaz:
https://doaj.org/article/57ec30064d9d418cad7b1d3aca5d3bb8
Autor:
Joseph D. Zak
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Olfactory sensory neurons are found deep within the nasal cavity at a spatially restricted sheet of sensory epithelium. Due to their location behind the nasal turbinates, accessing these cells for physiological measurements in living animals is chall
Externí odkaz:
https://doaj.org/article/1c8f62104a0047c3a3c9b453b89aa40f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Odor blends contain molecules that activate unique, overlapping populations of sensory neurons (OSNs). Here, by imaging OSN axon terminals, as well as their cell bodies within the olfactory epithelium, the authors find widespread antagonistic interac
Externí odkaz:
https://doaj.org/article/1336675ee1e24ce08fcf05a0a0ced58d
Autor:
Dinu F. Albeanu, Allison C. Provost, Prateek Agarwal, Edward R. Soucy, Joseph D. Zak, Venkatesh N. Murthy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Olfactory marker protein (OMP) expressed in all olfactory sensory neurons (OSN) is required for proper signal transduction and odor discrimination. Here, the authors report that OMP deletion leads to formation of glomeruli with axons from heterogeneo
Externí odkaz:
https://doaj.org/article/562b4855157e4ab08c903da577a9a0eb
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract The calcium-activated chloride channel anoctamin-2 (Ano2) is thought to amplify transduction currents in olfactory receptor neurons (ORNs), a hypothesis supported by previous studies in dissociated neurons from Ano2 −/− mice. Paradoxical
Externí odkaz:
https://doaj.org/article/3aec2c696f2b468d9d6f10a8e92a9143
Autor:
Prateek Agarwal, Allison C. Provost, Venkatesh N. Murthy, Dinu F. Albeanu, Edward R. Soucy, Joseph D. Zak
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Inputs from olfactory sensory neuron (OSN) axons expressing the same type of odorant receptor (OR) converge in the glomerulus of the main olfactory bulb. A key marker of mature OSNs is olfactory marker protein (OMP), whose deletion has been associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0774f51971b8520f120825f59ebeb3d8
Autor:
Joseph D. Zak, Nathan E. Schoppa
Publikováno v:
The Journal of Physiology. 600:393-417
GABAergic periglomerular (PG) cells in the olfactory bulb are proposed to mediate an intraglomerular 'high-pass' filter through inhibition targeted onto a glomerulus. With this mechanism, weak stimuli (e.g. an odour with a low affinity for an odouran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a92961a86eb3d9c212c27471c8989a
https://doi.org/10.1113/jp282374
https://doi.org/10.1113/jp282374
Publikováno v:
eLife, Vol 7 (2018)
Natural environments feature mixtures of odorants of diverse quantities, qualities and complexities. Olfactory receptor neurons (ORNs) are the first layer in the sensory pathway and transmit the olfactory signal to higher regions of the brain. Yet, t
Externí odkaz:
https://doaj.org/article/6c8b946a2b05431594f570c65d248aba
Autor:
Nathan E. Schoppa, Joseph D. Zak
GABAergic periglomerular (PG) cells in the olfactory bulb are proposed to mediate an intraglomerular “high-pass” filter through inhibition targeted onto a glomerulus. With this mechanism, weak stimuli (e.g., an odor with a low affinity for an odo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f239da9a5eeb8fd6c5a195c696c52e2
https://doi.org/10.1101/2021.09.14.460371
https://doi.org/10.1101/2021.09.14.460371
Autor:
Nathan E. Schoppa, Joseph D. Zak
The local circuitry within olfactory bulb glomeruli filters, transforms, and facilitates information transfer from olfactory sensory neurons to bulb output neurons. Two key elements of this circuit are glutamatergic tufted cells (TCs) and GABAergic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae0e889e49f8b38dd18a82e1a3a20a78
https://doi.org/10.1101/2021.07.21.453150
https://doi.org/10.1101/2021.07.21.453150