Zobrazeno 1 - 10
of 418
pro vyhledávání: '"Joseph Chen"'
Autor:
Bradley J. Mahaffey, Zachary P. Fowler, Zoe Lung, Vivien Dang, Hyunchul Lee, Allison McKenzie Johnson, Marco A. Munoz, Dylan A. Goodin, Hermann B. Frieboes, Brian J. Williams, Joseph Chen
Publikováno v:
APL Bioengineering, Vol 8, Iss 3, Pp 036101-036101-9 (2024)
Glioblastoma (GBM) is a highly invasive, aggressive brain cancer that carries a median survival of 15 months and is resistant to standard therapeutics. Recent studies have demonstrated that intratumoral heterogeneity plays a critical role in promotin
Externí odkaz:
https://doaj.org/article/c2ae37e75d8844f780bc3b243f57de78
Autor:
Akshitkumar M. Mistry, Jonah Daneshmand, SeonYeong Jamie Seo, Norman L. Lehman, Donald M. Miller, Dylan A. Goodin, Hermann B. Frieboes, Joseph Chen, Adrianna Masters, Brian J. Williams, Kavitha Yaddanapudi
Publikováno v:
Current Oncology, Vol 31, Iss 3, Pp 1183-1194 (2024)
Background: Glioblastoma (GBM) tumors are rich in tumor-associated microglia/macrophages. Changes associated with treatment in this specific cell population are poorly understood. Therefore, we studied changes in gene expression of tumor-associated m
Externí odkaz:
https://doaj.org/article/85788d9952204c5aad467501a1f17cd6
Publikováno v:
Frontiers in Audiology and Otology, Vol 2 (2024)
IntroductionA common concern for individuals with moderate-to-profound hearing loss who have received a cochlear implants (CIs) is difficulty following conversations in noisy environments. A possible reason is the increased use of cognitive resources
Externí odkaz:
https://doaj.org/article/642b80a52d50483fafe68b46df7c270b
Autor:
Qian Yang, Michael Patrick, Jian Lu, Joseph Chen, Yongqing Zhang, Humza Hemani, Elin Lehrmann, Supriyo De, Nan-ping Weng
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell activation is a tightly controlled process involving both positive and negative regulators. The precise mechanisms governing the negative regulators in T cell proliferation remain incompletely understood. Here, we report that homeodomain-only
Externí odkaz:
https://doaj.org/article/d48f124f5e504222a3d352cb63036beb
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Autor:
Stephen Ryan Chen, Maria Amelia Munsch, Joseph Chen, Brandon Keith Couch, Richard Alan Wawrose, Anthony Abimbade Oyekan, Joshua Adjei, William F. Donaldson, Joon Yung Lee, Jeremy DeWitt Shaw
Publikováno v:
Asian Spine Journal, Vol 17, Iss 3, Pp 549-558 (2023)
Study Design Retrospective review of prospectively collected cohort. Purpose To identify differences in treatment and mortality of spine fractures in patients with ankylosing conditions of the spine. Overview of Literature Ankylosing spondylitis (AS)
Externí odkaz:
https://doaj.org/article/785cfc0de3854bc49df315f94060121f
Autor:
Miriam Aceves, Ashley Tucker, Joseph Chen, Katie Vo, Joshua Moses, Prakruthi Amar Kumar, Hannah Thomas, Diego Miranda, Gabrielle Dampf, Valerie Dietz, Matthew Chang, Aleena Lukose, Julius Jang, Sneha Nadella, Tucker Gillespie, Christian Trevino, Andrew Buxton, Anna L. Pritchard, Peyton Green, Dylan A. McCreedy, Jennifer N. Dulin
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy for replacing lost neurons following spinal cord injury (SCI). However, how graft cellular composition influences regeneration and synaptogenesis of host axon p
Externí odkaz:
https://doaj.org/article/7042997fe63649e7822c5fb8222e68ab
Autor:
Brandon T. Paul, Münir Demir Bajin, Mila Uzelac, Joseph Chen, Trung Le, Vincent Lin, Andrew Dimitrijevic
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Deaf individuals who use a cochlear implant (CI) have remarkably different outcomes for auditory speech communication ability. One factor assumed to affect CI outcomes is visual crossmodal plasticity in auditory cortex, where deprived audito
Externí odkaz:
https://doaj.org/article/9bee4d25e33140e783eca83f2b7f6afe
Autor:
Jian Lu, Raheel Ahmad, Thomas Nguyen, Jeffrey Cifello, Humza Hemani, Jiangyuan Li, Jinguo Chen, Siyi Li, Jing Wang, Achouak Achour, Joseph Chen, Meagan Colie, Ana Lustig, Christopher Dunn, Linda Zukley, Chee W. Chia, Irina Burd, Jun Zhu, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The characterisation of T cells during aging is important to predict functional outcomes in vaccination or infection. Here the authors use flow cytometry and scRNA sequencing to transcriptionally age CD8 T cells and then use a machine learning model
Externí odkaz:
https://doaj.org/article/06820e5848b3446782b42bbc3c749de7
Publikováno v:
Bioengineering, Vol 11, Iss 1, p 93 (2024)
GBM is the most aggressive and common form of primary brain cancer with a dismal prognosis. Current GBM treatments have not improved patient survival, due to the propensity for tumor cell adaptation and immune evasion, leading to a persistent progres
Externí odkaz:
https://doaj.org/article/ff43e9c9d94445c1922b528c7fcc1ca7