Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joseph Chabenne"'
Autor:
Rongjun He, Stephanie A. Mowery, Joseph Chabenne, Brian Finan, John P. Mayer, Richard D. DiMarchi
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics. We report a convenient and rapid procedure for one-pot, site-speci
Externí odkaz:
https://doaj.org/article/5f473071bd074626af80c6acfe0da0f8
Autor:
Walid Atef Massoud, Pascal Eschwege, Pascal Hajj, Ayman Awad, Lahbib AoubidIaaza, Joseph Chabenne, Yacine Hammoudi, Stéphane Droupy, Gérard Benoit
Publikováno v:
Urology Journal, Vol 8, Iss 4, Pp 333-334 (2011)
Externí odkaz:
https://doaj.org/article/a5ef71e84f2048509de494c3b1715e22
Autor:
Walid Massoud, Pascal Hajj, Ayman Awad, Joseph Chabenne, Pascal Eschwege, Stéphane Droupy, Yacine Hammoudi, Gérard Benoît
Publikováno v:
Urology Journal, Vol 7, Iss 2, Pp 136-137 (2010)
Externí odkaz:
https://doaj.org/article/0b8261fd5460418c9bbe51e89fd11424
Publikováno v:
Journal of Medicinal Chemistry. 63:3447-3460
Glucagon counters insulin's effects on glucose metabolism and serves as a rescue medicine in the treatment of hypoglycemia. Acute hypoglycemia, a common occurrence in insulin-dependent diabetes, is the central obstacle to correcting high blood glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8dfeb1be3cee8523552e3255092f6be
https://doi.org/10.1021/acs.jmedchem.9b01493
https://doi.org/10.1021/acs.jmedchem.9b01493
Publikováno v:
Communications Chemistry, Vol 1, Iss 1, Pp 1-7 (2018)
Insulins, relaxins, and other insulin-like peptides present a longstanding synthetic challenge due to their unique cysteine-rich heterodimeric structure. While their three disulfide signature is conserved within the insulin superfamily, sequences of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30525b6b1cc0f5e1ebb9c0dd6907f97f
http://link.springer.com/article/10.1038/s42004-018-0036-9
http://link.springer.com/article/10.1038/s42004-018-0036-9
Autor:
Cassie Holleman, Darleen A. Sandoval, Jeong-a Kim, Joseph Chabenne, Diego Perez-Tilve, Daniel J. Drucker, Teayoun Kim, Deanna M. Arble, Richard D. DiMarchi, Christine Loyd, Shelly Nason, Kirk M. Habegger, Nickki Ottaway
Publikováno v:
Diabetes
Glucagon receptor (GCGR) agonists cause hyperglycemia but also weight loss. However, GCG-like peptide 1 receptor (GLP1R)/GCGR mixed agonists do not exhibit the diabetogenic effects often attributed to GCGR activity. Thus, we sought to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dd483ef881e99594fb2df5e1ae3481
https://pubmed.ncbi.nlm.nih.gov/30150304
https://pubmed.ncbi.nlm.nih.gov/30150304
Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity
Publikováno v:
Journal of Peptide Science. 21:223-230
This report describes the chemical synthesis and biological characterization of novel three-chain insulin analogs with a destabilized secondary structure. The analogs, obtained by chemical synthesis via a single-chain precursor and selective enzymati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8144259c53c2672f9d8f2fd3c2768ea3
https://doi.org/10.1002/psc.2744
https://doi.org/10.1002/psc.2744
Autor:
David L. Smiley, Maria DiMarchi Chabenne, Vasily M. Gelfanov, Richard D. DiMarchi, Jay J. Levy, Joseph Chabenne, Yan Zhao
Publikováno v:
Molecular Metabolism
For more than half a century glucagon has been used as a critical care medicine in the treatment of life-threatening hypoglycemia. It is commercially supplied as a lyophilized powder intended to be solubilized in dilute aqueous hydrochloric acid imme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c59ac39847411ddc2ad7b705249c17
https://doi.org/10.1016/j.molmet.2014.01.006
https://doi.org/10.1016/j.molmet.2014.01.006
Autor:
Joseph Chabenne, Daniel J. Drucker, Christelle Veyrat-Durebex, Kristy M. Heppner, Diego Perez-Tilve, Françoise Rohner-Jeanrenaud, Matthias H. Tschöp, Richard D. DiMarchi, Sarah Kathleen Haas Lockie, Gayathri Ananthakrishnan, Donald A. Morgan, Nilika Chaudhary, Brian J. Oldfield, Kamal Rahmouni
Publikováno v:
Diabetes
Diabetes, Vol. 61, No 11 (2012) pp. 2753-62
Diabetes, Vol. 61, No 11 (2012) pp. 2753-62
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like peptide 1 receptor (GLP-1R)–deficient mice after the administration of the proglucagon-derived peptides (PGDPs) glucagon-like peptide (GLP-1), glucago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786d7cfecf6f8bb3e1eeee818df8031a
http://europepmc.org/articles/PMC3478556
http://europepmc.org/articles/PMC3478556
Autor:
James Patterson, Richard D. DiMarchi, Pengyun Li, Maria DiMarchi Chabenne, Vasily M. Gelfanov, Jonathan Day, Joseph Chabenne
Publikováno v:
Journal of Peptide Science. 17:218-225
Glucagon and glucagon-like peptide-1 (GLP-1)are two structurally related hormones that acutely regulate glucose control in opposite directions through homologous receptors. The molecular basis for selectivity between these two hormones and their rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a103eefde1c1d5e53a79355238327a47
https://doi.org/10.1002/psc.1317
https://doi.org/10.1002/psc.1317