PDGF receptor signaling in osteoblast lineage cells controls bone resorption through upregulation of csf1 expression

Autor: Christina Møller Andreasen, Julia Brun, Thomas Levin Andersen, Cyril Thouverey, Joseph Caverzasio, Charlotte Ejersted

Publikováno v: Journal of Bone and Mineral Research (2020)
Brun, J, Andreasen, C M, Ejersted, C, Andersen, T L, Caverzasio, J & Thouverey, C 2020, ' PDGF Receptor Signaling in Osteoblast Lineage Cells Controls Bone Resorption Through Upregulation of Csf1 Expression ', Journal of Bone and Mineral Research, vol. 35, no. 12, pp. 2458-2469 . https://doi.org/10.1002/jbmr.4150

The physiological functions of platelet-derived growth factor receptors (PDGFRs) α and β in osteoblast biology and bone metabolism remain to be established. Here, we show that PDGFRA and PDGFRB genes are expressed by osteoblast-lineage canopy and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d88f3000279720489fb7d8a0a9ff6c
https://archive-ouverte.unige.ch/unige:143609

Selective inhibition of Src family kinases by SU6656 increases bone mass by uncoupling bone formation from resorption in mice

Autor: Joseph Caverzasio, Cyril Thouverey, Serge Ferrari

Publikováno v: Bone, Vol. 113 (2018) pp. 95-104

Mice deficient in the non-receptor tyrosine kinase Src exhibit high bone mass due to impaired bone resorption and increased bone formation. Although several Src family kinase inhibitors inhibit bone resorption in vivo, they display variable effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b714e269892fa5dcbf5326cc6f904ca0
https://archive-ouverte.unige.ch/unige:107121

Predominant role of PDGF receptor transactivation in Wnt3a-induced osteoblastic cell proliferation

Autor: Joseph Caverzasio, Cyril Thouverey, Emmanuel Biver

Publikováno v: J Bone Miner Res.
Journal of Bone and Mineral Research, Vol. 28, No 2 (2013) pp. 260-270
JBMR

Previous studies have shown that Wnt3a enhances the proliferation and inhibits the osteogenic differentiation of human mesenchymal stem cells (hMSCs). In this study, we investigated the signaling pathways involved in Wnt3a-induced osteoblastic cell p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144e6e55540deb687023e4f46cc300f2
https://www.ncbi.nlm.nih.gov/pubmed/22927028

The p38a MAPK positively regulates osteoblast function and postnatal bone acquisition

Autor: Joseph Caverzasio, Cyril Thouverey

Publikováno v: Cell Mol Life Sci.
Cellular and Molecular Life Sciences, Vol. 69, No 18 (2012) pp. 3115-3125
Cell Mol Life Sci
Cellular Molecular Life Science

Bone continuously remodels throughout life by coordinated actions of osteoclasts and osteoblasts. Abnormalities in either osteoclast or osteoblast functions lead to bone disorders. The p38 MAPK pathway has been shown to be essential in controlling os

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27348a6d81bf30503d95e7ae4c02ec9
https://www.ncbi.nlm.nih.gov/pubmed/22527716

Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolism

Autor: Patrick Ammann, Shizuko Nagao, Yutaka Oiso, Ryosuke Kaneko, Keiko Nishiwaki-Yasuda, Atsushi Suzuki, Mitsuyasu Itoh, Sahoko Sekiguchi, Masumi Hirabayashi, Joseph Caverzasio, Shogo Asano

Publikováno v: J Bone Miner Metab
Journal of Bone and Mineral Metabolism, Vol. 28, No 2 (2010) pp. 139-148

The type III inorganic phosphate (Pi) transporter Pit-1 was previously found to be preferentially expressed in developing long bones. Several studies also described a regulation of its expression in cultured bone cells by osteotropic factors, suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9d647c580d45ef3671777274fcfbe2