Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joseph C. Yawe"'
Autor:
Marina T. DiStefano, Michael P. Czech, Joseph C. Yawe, Rachel J. Roth Flach, Lorena Garcia Menendez, Mark J. S. Kelly, Ozlem Senol-Cosar, Laura V. Danai
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 313:E303-E313
The blood vasculature responds to insulin, influencing hemodynamic changes in the periphery, which promotes tissue nutrient and oxygen delivery and thus metabolic function. The lymphatic vasculature regulates fluid and lipid homeostasis, and impaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9e6ce5a22ec3952c57aa299293689c
https://doi.org/10.1152/ajpendo.00037.2017
https://doi.org/10.1152/ajpendo.00037.2017
Autor:
Yvonne J. K. Edwards, Laura V. Danai, Michael P. Czech, Chang-An Guo, Joseph C. Yawe, Rachel J. Roth Flach, Sharvari Gujja
Publikováno v:
Molecular and Cellular Biology. 36:1740-1749
The molecular mechanisms underlying lymphatic vascular development and function are not well understood. Recent studies have suggested a role for endothelial cell (EC) mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) in developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d615055ba11df091201d65372e2f74
https://doi.org/10.1128/mcb.01121-15
https://doi.org/10.1128/mcb.01121-15
Autor:
Pranitha Vangala, Karen Gallagher-Dorval, Sarah M. Nicoloro, Yuefei Shen, Joseph C. Yawe, Jessica Cohen, Richard A. Perugini, Michaela Tencerova, Olga T. Gupta, David J. Pedersen, Lorena Garcia-Menendez, Michael P. Czech, Myriam Aouadi
Publikováno v:
The FASEB Journal. 29:2959-2969
Obesity promotes insulin resistance associated with liver inflammation, elevated glucose production, and type 2 diabetes. Although insulin resistance is attenuated in genetic mouse models that suppress systemic inflammation, it is not clear whether l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c158a9c64f6ccf893056e8a7c0ab2dc
https://doi.org/10.1096/fj.15-270496
https://doi.org/10.1096/fj.15-270496
Autor:
Yuefei Shen, Pranitha Vangala, Jessica Cohen, Shinya U. Amano, Sarah M. Nicoloro, Michael P. Czech, Joseph C. Yawe, Michaela Tencerova, Myriam Aouadi
Publikováno v:
Cell Metabolism. 19:162-171
SummaryAdipose tissue (AT) of obese mice and humans accumulates immune cells, which secrete cytokines that can promote insulin resistance. AT macrophages (ATMs) are thought to originate from bone-marrow-derived monocytes, which infiltrate the tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e01b1345babf0335f67edd441dfb6e1
https://doi.org/10.1016/j.cmet.2013.11.017
https://doi.org/10.1016/j.cmet.2013.11.017
Autor:
Shinya U. Amano, Myriam Aouadi, Sarah M. Nicoloro, Jessica Cohen, Pranitha Vangala, Michaela Tencerova, Joseph C. Yawe, Michael P. Czech
Publikováno v:
Proceedings of the National Academy of Sciences. 110:8278-8283
Adipose tissue (AT) inflammation and infiltration by macrophages is associated with insulin resistance and type 2 diabetes in obese humans, offering a potential target for therapeutics. However, whether AT macrophages (ATMs) directly contribute to sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06072741c48579a0f9d1df5167a2fc82
https://doi.org/10.1073/pnas.1300492110
https://doi.org/10.1073/pnas.1300492110
Autor:
Jessica Cohen, Pranitha Vangala, Joseph C. Yawe, Michael P. Czech, Shinya U. Amano, Yuefei Shen, Sarah M. Nicoloro, Myriam Aouadi, Michaela Tencerova
Publikováno v:
Cohen, J L, Shen, Y, Aouadi, M, Vangala, P, Tencerova, M, Amano, S U, Nicoloro, S M, Yawe, J C & Czech, M P 2016, ' Peptide-and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA ', Molecular Pharmaceutics, vol. 13, no. 3, pp. 964-978 . https://doi.org/10.1021/acs.molpharmaceut.5b00831
Translation of siRNA technology into the clinic is limited by the need for improved delivery systems that target specific cell types. Macrophages are particularly attractive targets for RNAi therapy because they promote pathogenic inflammatory respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caf88296b889e21e513790651dfbabf
https://europepmc.org/articles/PMC5153885/
https://europepmc.org/articles/PMC5153885/
Autor:
Joseph C. Yawe, Lorena Garcia Menendez, Samit Kumar Bhattacharya, Christian Cortes, Myriam Aouadi, Pranitha Vangala, Anouch Matevossian, Timothy P. Fitzgibbons, Wei Zheng, Rachel J. Roth Flach, Michael P. Czech, Leonard Buckbinder, Laura V. Danai, Nana Hagan, Marcus P. Cooper, Athanasia Skoura
Publikováno v:
Nature Communications
Nature Publishing Group
Nature Publishing Group
Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d41ecf390a782a43fb6673c6b4c4e18
http://europepmc.org/articles/PMC4703891
http://europepmc.org/articles/PMC4703891
Autor:
Sarah M. Nicoloro, Joseph C. Yawe, Myriam Aouadi, Pranitha Vangala, Michaela Tencerova, Yuefei Shen, Michael P. Czech, Jessica Cohen
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 307(4)
Proinflammatory pathways in adipose tissue macrophages (ATMs) can impair glucose tolerance in obesity, but ATMs may also be beneficial as repositories for excess lipid that adipocytes are unable to store. To test this hypothesis, we selectively targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da37e75f28231819887de876064b3a35
https://pubmed.ncbi.nlm.nih.gov/24986598
https://pubmed.ncbi.nlm.nih.gov/24986598
Autor:
Uwe H. F. Bunz, Avinash Bajaj, Joseph C. Yawe, Oscar R. Miranda, Vincent M. Rotello, Subinoy Rana, D. Joseph Jerry
Publikováno v:
Chemical Science. 1:134
Gold nanoparticle-green fluorescent protein (NP-GFP) based arrays have been created for rapid identification of mammalian cells on the basis of cell surface properties. Highly reproducible characteristic patterns were obtained from different cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea54821789b17b0bd084958bb7928cc1
https://doi.org/10.1039/c0sc00165a
https://doi.org/10.1039/c0sc00165a