Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Joseph C. Sun"'
Autor:
Rui Li, Cristian Camilo Galindo, Dominique Davidson, Huaijian Guo, Ming-Chao Zhong, Jin Qian, Bin Li, Zsolt Ruzsics, Colleen M. Lau, Timothy E. O'Sullivan, Silvia M. Vidal, Joseph C. Sun, André Veillette
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113800- (2024)
Summary: Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H+ natural killer (NK) cells, which are virus specific and considered to be “adaptive” or “memory” NK cells. Here, we find that signaling lymp
Externí odkaz:
https://doaj.org/article/adb6c93e5f704d00b240fb56f26c9322
Autor:
Gabriela M. Wiedemann, Simon Grassmann, Colleen M. Lau, Moritz Rapp, Alejandro V. Villarino, Christin Friedrich, Georg Gasteiger, John J. O’Shea, Joseph C. Sun
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108498- (2020)
Summary: Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell
Externí odkaz:
https://doaj.org/article/cd2ef75af09d4bb1bf1ac555481e0d9d
Autor:
Carlos Diaz-Salazar, Joseph C. Sun
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108186- (2020)
Summary: Natural killer (NK) cells play a critical role in controlling viral infections, coordinating the response of innate and adaptive immune systems. They also possess certain features of adaptive lymphocytes, such as undergoing clonal proliferat
Externí odkaz:
https://doaj.org/article/361db0195a4f46e2b5a1c48f9c9637bd
Autor:
Sam Sheppard, Iona S. Schuster, Christopher E. Andoniou, Clement Cocita, Thomas Adejumo, Sam K.P. Kung, Joseph C. Sun, Mariapia A. Degli-Esposti, Nadia Guerra
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3385-3392 (2018)
Summary: TRAIL is an apoptosis-inducing ligand constitutively expressed on liver-resident type 1 innate lymphoid cells (ILC1s) and a subset of natural killer (NK) cells, where it contributes to NK cell anti-tumor, anti-viral, and immunoregulatory fun
Externí odkaz:
https://doaj.org/article/070be39fed8543abb9f36404fb76216c
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 636-644 (2016)
Despite robust secondary T cell expansion primed by vaccination, the impact on primary immune responses to heterotypic antigens remains undefined. Here we show that secondary expansion of epitope-specific memory CD8+ T cells primed by prior infection
Externí odkaz:
https://doaj.org/article/42330f531ee14dbfb433b4cf9d14bdab
Autor:
Wei-Feng Yen, Rahul Sharma, Montserrat Cols, Colleen M. Lau, Ashutosh Chaudhry, Priyanka Chowdhury, William T. Yewdell, Bharat Vaidyanathan, Amy Sun, Maryaline Coffre, Joseph N. Pucella, Chun-Chin Chen, Maria Jasin, Joseph C. Sun, Alexander Y. Rudensky, Sergei B. Koralov, Jayanta Chaudhuri
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1472-1486.e5 (2019)
Summary: The immunoglobulin heavy chain (Igh) locus features a dynamic chromatin landscape to promote class switch recombination (CSR), yet the mechanisms that regulate this landscape remain poorly understood. CHD4, a component of the chromatin remod
Externí odkaz:
https://doaj.org/article/ed2f3bea71bc4f469ef90f6397a16508
Autor:
Timothy E. O’Sullivan, Clair D. Geary, Orr-El Weizman, Theresa L. Geiger, Moritz Rapp, Gerald W. Dorn II, Michael Overholtzer, Joseph C. Sun
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 1910-1919 (2016)
Autophagy is an essential cellular survival mechanism that is required for adaptive lymphocyte development; however, its role in innate lymphoid cell (ILC) development remains unknown. Furthermore, the conditions that promote lymphocyte autophagy dur
Externí odkaz:
https://doaj.org/article/a5f3f3d094ee40ddb4b92e8afff41133
Autor:
Joseph C. Sun, Lewis L. Lanier
Publikováno v:
Viruses, Vol 1, Iss 3, Pp 362-382 (2009)
During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, lead
Externí odkaz:
https://doaj.org/article/dbc1cb73c1454c65acc2e2d64958c00d
Autor:
Jing Hu, Francisco J. Sánchez-Rivera, Zhenghan Wang, Gabriela N. Johnson, Yu-jui Ho, Karuna Ganesh, Shigeaki Umeda, Siting Gan, Adriana M. Mujal, Rebecca B. Delconte, Jessica P. Hampton, Huiyong Zhao, Sanjay Kottapalli, Elisa de Stanchina, Christine A. Iacobuzio-Donahue, Dana Pe’er, Scott W. Lowe, Joseph C. Sun, Joan Massagué
Publikováno v:
Nature. 616:806-813
Autor:
Suelen Martins Perobelli, Chi L. Nguyen, Anastasia I. Kousa, Jonathan U. Peled, Joseph C. Sun, Justin R. Cross, Eli Zamir, Robert R. Jenq, Sebastien Monette, Melody Smith, Melissa D. Docampo, Ann E. Slingerland, Christoph K. Stein-Thoeringer, Clair D. Geary, Itamar Greenfield, Marina Burgos da Silva, Sophia R. Lieberman, Nicole Lee, Yusuke Shono, Gabe K Armijo, Emmanuel A Dwomoh, Kate A Markey, Marcel R M Rm van den Brink, Amina Lazrak, Katherine B Nichols, Santosha Vardhana
Publikováno v:
Blood
The intestinal microbiota is essential for the fermentation of dietary fiber into short-chain fatty acids (SCFA) such as butyrate, acetate, and propionate. SCFAs can bind to the G-protein-coupled receptors GPR43 and GPR109A (HCAR2), with varying affi