Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joseph C. Pearson"'
Autor:
Florian Brandes, Melanie Borrmann, Dominik Buschmann, Agnes S. Meidert, Marlene Reithmair, Markus Langkamp, Lutz Pridzun, Benedikt Kirchner, Jean-Noël Billaud, Nirav M. Amin, Joseph C. Pearson, Matthias Klein, Daniela Hauer, Clarissa Gevargez Zoubalan, Anja Lindemann, Alexander Choukér, Thomas W. Felbinger, Ortrud K. Steinlein, Michael W. Pfaffl, Ines Kaufmann, Gustav Schelling
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-22 (2021)
Abstract Background Progranulin is a widely expressed pleiotropic growth factor with a central regulatory effect during the early immune response in sepsis. Progranulin signaling has not been systematically studied and compared between sepsis, commun
Externí odkaz:
https://doaj.org/article/382b9dcb011c432dbd6249d8b5d66a74
Autor:
Laurina Manning, Ellie S. Heckscher, Maria D. Purice, Jourdain Roberts, Alysha L. Bennett, Jason R. Kroll, Jill L. Pollard, Marie E. Strader, Josh R. Lupton, Anna V. Dyukareva, Phuong Nam Doan, David M. Bauer, Allison N. Wilbur, Stephanie Tanner, Jimmy J. Kelly, Sen-Lin Lai, Khoa D. Tran, Minoree Kohwi, Todd R. Laverty, Joseph C. Pearson, Stephen T. Crews, Gerald M. Rubin, Chris Q. Doe
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 1002-1013 (2012)
Here, we describe the embryonic central nervous system expression of 5,000 GAL4 lines made using molecularly defined cis-regulatory DNA inserted into a single attP genomic location. We document and annotate the patterns in early embryos when neurogen
Externí odkaz:
https://doaj.org/article/8e07ffd1de9b4e90a4c3b34e354a3529
Autor:
Joseph C. Pearson, Stephen T. Crews
Publikováno v:
Developmental Biology. 392(2):466-482
Transcriptional enhancers integrate information derived from transcription factor binding to control gene expression. One key question concerns the extent of trans- and cis-regulatory variation in how co-expressed genes are controlled. The Drosophila
Publikováno v:
Development (Cambridge, England). 143(20)
One of the key issues in studying transcriptional regulation during development is how to employ genome-wide assays that reveals sites of open chromatin and transcription factor binding to efficiently identify biologically relevant genes and enhancer
Autor:
Marie E. Strader, Laurina Manning, Stephanie Tanner, Minoree Kohwi, Alysha L. Bennett, Todd R. Laverty, David M. Bauer, Anna V. Dyukareva, Jimmy J. Kelly, Maria D. Purice, Jason R. Kroll, Allison N. Wilbur, Jill L. Pollard, Khoa D. Tran, Josh R. Lupton, Chris Q. Doe, Phuong Nam Doan, Joseph C. Pearson, Jourdain Roberts, Stephen T. Crews, Sen-Lin Lai, Ellie S. Heckscher, Gerald M. Rubin
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 1002-1013 (2012)
SummaryHere, we describe the embryonic central nervous system expression of 5,000 GAL4 lines made using molecularly defined cis-regulatory DNA inserted into a single attP genomic location. We document and annotate the patterns in early embryos when n
Publikováno v:
Developmental Biology. 361:232-244
The Drosophila CNS midline glia (MG) are multifunctional cells that ensheath and provide trophic support to commissural axons, and direct embryonic development by employing a variety of signaling molecules. These glia consist of two functionally dist
Autor:
Stephen T. Crews, Joseph C. Pearson
Publikováno v:
Current Biology. 19:R241-R246
The authors would like to thank Peter Harte and Mark Ptashne for helpful and stimulating comments on the manuscript. Our lab's research is supported by grants from the NIH and NSF. The UNC Developmental Biology NIH training grant provided support to
Publikováno v:
Nature Reviews Genetics. 6:893-904
With their power to shape animal morphology, few genes have captured the imagination of biologists as the evolutionarily conserved members of the Hox clusters have done. Recent research has provided new insight into how Hox proteins cause morphologic
Publikováno v:
Science. 308:381-385
We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head ( grh ) function and binding sit
Autor:
Stephen T. Crews, Joseph C. Pearson
Publikováno v:
Bioinformatics. 29:1690-1692
Many algorithms analyze enhancers for overrepresentation of known and novel motifs, with the goal of identifying binding sites for direct regulators of gene expression. Twine is a Java GUI with multiple graphical representations ('Views') of enhancer