Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Joseph C. Lownik"'
Autor:
Luigi Marino, Bin Ni, Jared S. Farrar, Joseph C. Lownik, Janina V. Pearce, Rebecca K. Martin, Francesco S. Celi
Publikováno v:
Adipocyte, Vol 13, Iss 1 (2024)
ABSTRACTA Disintegrin And Metalloproteinase domain-containing protein 10 (ADAM10), is involved in several metabolic and inflammatory pathways. We speculated that ADAM10 plays a modulatory role in adipose tissue inflammation and metabolism. To this en
Externí odkaz:
https://doaj.org/article/ca0aa1675b914de79d66fe6633e60097
Autor:
Jared S. Farrar, Joseph C. Lownik, Grayson W. Way, Matthew C. Rodriguez, Francesco S. Celi, Rebecca K. Martin
Publikováno v:
Adipocyte, Vol 10, Iss 1, Pp 91-100 (2021)
The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes. In the process of developing a new mouse model utilizing the adipocyte selective Adipoq-Cre tr
Externí odkaz:
https://doaj.org/article/d2fcfa7102594f03a2d1117be7e6ed78
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 509-522 (2020)
The role of ADAM17, its substrates, and its natural inhibitor has been well studied in the context of inflammation, including metabolic inflammation, with mixed results. Previous studies examining global Adam17 knockdown models and ADAM17 inhibition
Externí odkaz:
https://doaj.org/article/eb8e21319c094f31a8bf17549bb15568
Publikováno v:
Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100803- (2020)
The role of the inducible costimulatory of T cells (ICOS) has been shown to be important for many different T cell outcomes and is indispensable for follicular helper T cell (TFH) responses. Since its discovery, there have been several studies on the
Externí odkaz:
https://doaj.org/article/3a93e54c42254dd89bdb7d19618c9f85
Autor:
Rebecca K. Martin, Sheela R. Damle, Yolander A. Valentine, Matthew P. Zellner, Briana N. James, Joseph C. Lownik, Andrea J. Luker, Elijah H. Davis, Martha M. DeMeules, Laura M. Khandjian, Fred D. Finkelman, Joseph F. Urban, Jr., Daniel H. Conrad
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1824-1834 (2018)
Summary: Helminth infection is known for generating large amounts of poly-specific IgE. Here we demonstrate that innate-like B1 cells are responsible for this IgE production during infection with the nematode parasites Nippostrongylus brasiliensis an
Externí odkaz:
https://doaj.org/article/f4577ef0704b41a9a257d4dd0468027d
Autor:
Joseph C. Lownik, Jared S. Farrar, Grayson W. Way, Angela McKay, Pavitra Roychoudhury, Alexander L. Greninger, Rebecca K. Martin
Publikováno v:
Diagnostics, Vol 11, Iss 10, p 1788 (2021)
SARS-CoV-2, the virus responsible for COVID-19, emerged in late 2019 and has since spread throughout the world, infecting over 200 million people. The fast spread of SARS-CoV-2 showcased the need for rapid and sensitive testing methodologies to help
Externí odkaz:
https://doaj.org/article/166799ff964b4e0785f66abb3acb3c05
Autor:
Janina V. Pearce, Jared S. Farrar, Joseph C. Lownik, Bin Ni, Shanshan Chen, Tiffany W. Kan, Francesco S. Celi
Publikováno v:
Biochemistry and Biophysics Reports, Vol 18, Iss , Pp - (2019)
Breast cancer remains a substantial clinical problem worldwide, and cancer-associated cachexia is a condition associated with poor prognosis in this and other malignancies. Adipose tissue is involved in the development and progression of cancer-assoc
Externí odkaz:
https://doaj.org/article/6835c2691f894862a432a99206e6e493
Publikováno v:
F1000Research, Vol 8 (2019)
Immunoglobulin E (IgE), though constitutively present at low levels, is most commonly studied in atopic disease where it plays a vital role in mast cell degranulation and in initiating a T helper 2 (Th2) response. With the advent of better detection
Externí odkaz:
https://doaj.org/article/fbc47ea0aa7f402ca88ff280fb390de5
Publikováno v:
The Journal of Molecular Diagnostics. 23:1671-1679
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, molecular diagnostic testing for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has faced substantial supply chain shortages and noteworthy delays in resu
Autor:
Rebecca K. Martin, Matthew C Rodriguez, Francesco S Celi, Grayson W. Way, Jared S. Farrar, Joseph C. Lownik
Publikováno v:
Adipocyte, Vol 10, Iss 1, Pp 91-100 (2021)
Adipocyte
article-version (VoR) Version of Record
Adipocyte
article-version (VoR) Version of Record
The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes. In the process of developing a new mouse model utilizing the adipocyte selective Adipoq-Cre tr