Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joseph C. Gonzalez"'
Publikováno v:
Immunological Reviews. 309:64-74
In this review, we discuss how IgG antibodies can modulate inflammatory signaling during viral infections with a focus on CD16a-mediated functions. We describe the structural heterogeneity of IgG antibody ligands, including subclass and glycosylation
Autor:
Saborni Chakraborty, Joseph C. Gonzalez, Benjamin L. Sievers, Vamsee Mallajosyula, Srijoni Chakraborty, Megha Dubey, Usama Ashraf, Bowie Yik-Ling Cheng, Nimish Kathale, Kim Quyen Thi Tran, Courtney Scallan, Aanika Sinnott, Arianna Cassidy, Steven T. Chen, Terri Gelbart, Fei Gao, Yarden Golan, Xuhuai Ji, Seunghee Kim-Schulze, Mary Prahl, Stephanie L. Gaw, Sacha Gnjatic, Thomas U. Marron, Miriam Merad, Prabhu S. Arunachalam, Scott D. Boyd, Mark M. Davis, Marisa Holubar, Chaitan Khosla, Holden T. Maecker, Yvonne Maldonado, Elizabeth D. Mellins, Kari C. Nadeau, Bali Pulendran, Upinder Singh, Aruna Subramanian, Paul J. Utz, Robert Sherwood, Sheng Zhang, Prasanna Jagannathan, Gene S. Tan, Taia T. Wang
Publikováno v:
Science translational medicine, vol 14, iss 635
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two prospective cohorts, early non-neutralizing, afucosylated immunoglobuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d71922fcd8a37cb20818c9a268fd390
https://escholarship.org/uc/item/9hs8r8gd
https://escholarship.org/uc/item/9hs8r8gd
Autor:
Benjamin L. Sievers, Saborni Chakraborty, Yong Xue, Terri Gelbart, Joseph C. Gonzalez, Arianna G. Cassidy, Yarden Golan, Mary Prahl, Stephanie L. Gaw, Prabhu S. Arunachalam, Catherine A. Blish, Scott D. Boyd, Mark M. Davis, Prasanna Jagannathan, Kari C. Nadeau, Bali Pulendran, Upinder Singh, Richard H. Scheuermann, Matthew B. Frieman, Sanjay Vashee, Taia T. Wang, Gene S. Tan
Publikováno v:
Science translational medicine, vol 14, iss 634
Sci Transl Med
Sci Transl Med
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that have mutations associated with increased transmission and antibody escape have arisen over the course of the current pandemic. Although the current vaccines have larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334fda2360b0c1bb8ad6398ec7212da7
https://escholarship.org/uc/item/2b50s6rq
https://escholarship.org/uc/item/2b50s6rq
Autor:
Benjamin L. Sievers, Saborni Chakraborty, Yong Xue, Terri Gelbart, Joseph C. Gonzalez, Arianna G. Cassidy, Yarden Golan, Mary Prahl, Stephanie L. Gaw, Prabhu S. Arunachalam, Catherine A. Blish, Scott D. Boyd, Mark M. Davis, Prasanna Jagannathan, Kari C. Nadeau, Bali Pulendran, Upinder Singh, Richard H. Scheuermann, Matthew Frieman, Sanjay Vashee, Taia T. Wang, Gene S. Tan
Multiple SARS-CoV-2 variants that possess mutations associated with increased transmission and antibody escape have arisen over the course of the current pandemic. While the current vaccines have largely been effective against past variants, the numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c4b905ccdba5ed93700b1987f27053e
https://doi.org/10.1101/2021.12.30.21268540
https://doi.org/10.1101/2021.12.30.21268540
Autor:
Joseph C. Gonzalez, Taia T. Wang
Publikováno v:
Immunity
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment during prophylaxi
Publikováno v:
Curr Opin Immunol
The effector activity of IgG antibodies is regulated at several levels, including IgG subclass, modifications of the Fc glycan, and the distribution of Type I and II Fcγ receptors (FcγR) on effector cells. Here, we explore how Fc glycosylation, par
Autor:
Saborni Chakraborty, Joseph C. Gonzalez, Benjamin L. Sievers, Vamsee Mallajosyula, Srijoni Chakraborty, Megha Dubey, Usama Ashraf, Bowie Yik-Ling Cheng, Nimish Kathale, Kim Quyen Thi Tran, Courtney Scallan, Aanika Sinnott, Arianna Cassidy, Steven T. Chen, Terri Gelbart, Fei Gao, Yarden Golan, Xuhuai Ji, Seunghee Kim-Schulze, Mary Prahl, Stephanie L. Gaw, Sacha Gnjatic, Thomas U. Marron, Miriam Merad, Prabhu S. Arunachalam, Scott D. Boyd, Mark M. Davis, Marisa Holubar, Chaitan Khosla, Holden T. Maecker, Yvonne Maldonado, Elizabeth D. Mellins, Kari C. Nadeau, Bali Pulendran, Upinder Singh, Aruna Subramanian, Paul J. Utz, Robert Sherwood, Sheng Zhang, Prasanna Jagannathan, Gene S. Tan, Taia T. Wang
Publikováno v:
bioRxiv
Serologic markers that predict severe COVID-19 disease trajectories could enable early medical interventions and reduce morbidity and mortality. We found that distinct features of IgG Fab and Fc domain structures were present within three days of a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59bab957c4383db848c9114a2bf138d
https://doi.org/10.1101/2021.05.25.445649
https://doi.org/10.1101/2021.05.25.445649
Autor:
Hai Li, Andrew Luo, Steven J. Chapin, Shelley Erin Ackerman, Marcin Kowanetz, Michael N. Alonso, Po Y. Ho, Arthur Lee, Karla Henning, Samuel C. Kimmey, Benjamin Ackerman, Joshua D. Gregorio, Brian Safina, Vishnu C. Ramani, David Dornan, Lauren Y. Sheu, Jennifer Melrose, Cecelia Pearson, Richard P. Laura, Bruce H. Devens, Justin A. Kenkel, Edgar G. Engleman, Lisa Blum, David Y. Jackson, Heidi N. Leblanc, Joseph C. Gonzalez, Grant Yonehiro, Yaron Carmi, Felix J. Hartmann, Sean C. Bendall, Murray L. Nguyen, Angela Luo, Jason C. Paik
Publikováno v:
Nat Cancer
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436acc59b100dcb9f23295f5a324b4fb
https://europepmc.org/articles/PMC9012298/
https://europepmc.org/articles/PMC9012298/
Autor:
Andrew Luo, Joseph C. Gonzalez, Richard P. Laura, Michael N. Alonso, Samuel C. Kimmey, David Y. Jackson, Shelley Erin Ackerman, David Dornan, Benjamin Ackerman, Edgar G. Engleman, Po Yi Ho, Felix J. Hartmann, Bruce H. Devens, Jason C. Paik, Sean C. Bendall, Arthur Lee, Steven J. Chapin, Cecelia Pearson, Karla Henning
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Immune stimulating antibody conjugates (ISACs) covalently attach TLR7/8 immune stimulants to tumor-targeting antibodies. ISACs can be delivered systemically and act locally in the tumor microenvironment by requiring the following biologica
Autor:
Sheng Zhang, Vamsee Mallajosyula, Jeffrey M. Schapiro, Haley L. Dugan, Saborni Chakraborty, Catherine A. Blish, Gene S. Tan, Scott D. Boyd, Kari C. Nadeau, Taia T. Wang, Tho D. Pham, Robert Sherwood, Prasanna Jagannathan, Upinder Singh, Anthony S. Buzzanco, Jason R. Andrews, Tasha Morales, Patrick C. Wilson, Matthew J. Memoli, Nimish Kathale, Benjamin A. Pinsky, Susan Providenza, Cindy Buffone, Jeffery K. Taubenberger, Markus M. Xie, Joseph C. Gonzalez, Karlie Edwards
Publikováno v:
medRxiv
Nature Immunology
Nature immunology
Nature Immunology
Nature immunology
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a public health crisis that is exacerbated by our poor understanding of correlates of immunity. SARS-CoV-2 infection can cause Coronavirus Disease 2019 (COVI