Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joseph C. Del Paggio"'
Autor:
Charlotte Ouimet, Nora Hutchinson, Catherine Wang, Carol Matyka, Joseph C. Del Paggio, Jonathan Kimmelman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Patients endure risk and uncertainty when they participate in clinical trials. We previously estimated that 12,217 patient-participants are required to bring a new cancer drug to market. However, many development efforts are aimed at extendi
Externí odkaz:
https://doaj.org/article/4e4333c0d0524cfaa0cdb75279358628
Autor:
J. Connor Wells, Adam Fundytus, Shubham Sharma, Wilma M. Hopman, Joseph C. Del Paggio, Bishal Gyawali, Deborah Mukherji, Nazik Hammad, C. S. Pramesh, Ajay Aggarwal, Richard Sullivan, Christopher M. Booth
Publikováno v:
Current Oncology, Vol 29, Iss 4, Pp 2530-2538 (2022)
Background: In this study, we compared and contrasted design characteristics, results, and publications of randomized controlled trials (RCTs) in gastrointestinal (GI), lung, and breast cancer. Methods: A PUBMED search identified phase III RCTs of an
Externí odkaz:
https://doaj.org/article/3692da3d8bdf477ab3d3a73898ca874c
Autor:
Shubham Sharma, J. Connor Wells, Wilma M. Hopman, Joseph C. Del Paggio, Bishal Gyawali, Nazik Hammad, Annette E. Hay, Christopher M. Booth
Publikováno v:
Current Oncology, Vol 28, Iss 2, Pp 1518-1527 (2021)
Canada has a long tradition of leading practice-changing clinical trials in oncology. Here, we describe methodology, results, and interpretation of oncology RCTs with Canadian involvement compared to RCTs from other high-income countries (HICs). A li
Externí odkaz:
https://doaj.org/article/47e3eda2b6014516883c1a3349a9f772
Autor:
Hannah Moyer, Merlin Bittlinger, Angela Nelson, Luciano Fernandez, Jacky Sheng, Yuetong Wang, Joseph C. Del Paggio, Jonathan Kimmelman
Publikováno v:
Journal of Clinical Epidemiology. 158:134-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::915072f696095e41b4ade00af0c6c39e
https://doi.org/10.1016/j.jclinepi.2023.03.028
https://doi.org/10.1016/j.jclinepi.2023.03.028
Autor:
Adam Fundytus, Joseph L. Pater, Christopher M. Booth, Michael Brundage, Joseph C Del Paggio, Annette E. Hay, Wilma M. Hopman, Bingshu E. Chen
Publikováno v:
JNCI: Journal of the National Cancer Institute. 113:1422-1428
Background Use of value framework thresholds in the design of clinical trials may increase the proportion of randomized controlled trials that identify clinically meaningful advances for patients. Existing frameworks have not been applied to the rese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512836f0e3ba6555a8056316208e78dc
https://doi.org/10.1093/jnci/djab051
https://doi.org/10.1093/jnci/djab051
Autor:
Ian F. Tannock, Joseph C Del Paggio
Publikováno v:
The Lancet Oncology. 20:1065-1069
Summary Background The fragility index of trial results—ie, the minimum number of changes from non-events to events resulting in loss of statistical significance—can provide a measure of confidence that a positive effect reported in a randomised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2087e17cf916d97cb30de05f1e06756
https://doi.org/10.1016/s1470-2045(19)30338-9
https://doi.org/10.1016/s1470-2045(19)30338-9
Autor:
Wilma M. Hopman, Annette E. Hay, J. Connor Wells, Christopher M. Booth, Nazik Hammad, Bishal Gyawali, Shubham Sharma, Joseph C Del Paggio
Publikováno v:
Current Oncology
Volume 28
Issue 2
Pages 143-1527
Current Oncology, Vol 28, Iss 143, Pp 1518-1527 (2021)
Volume 28
Issue 2
Pages 143-1527
Current Oncology, Vol 28, Iss 143, Pp 1518-1527 (2021)
Canada has a long tradition of leading practice-changing clinical trials in oncology. Here, we describe methodology, results, and interpretation of oncology RCTs with Canadian involvement compared to RCTs from other high-income countries (HICs). A li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21fc64be6d896360de0c9f5c4a922e8d
Autor:
C S Pramesh, J. Connor Wells, Christopher M. Booth, Nazik Hammad, Bishal Gyawali, Richard Sullivan, Shubham Sharma, Wilma M. Hopman, Ajay Aggarwal, Joseph C Del Paggio, Deborah Mukherji
Publikováno v:
JAMA oncology. 7(3)
The burden of cancer falls disproportionally on low-middle-income countries (LMICs). It is not well known how novel therapies are tested in current clinical trials and the extent to which they match global disease burden.To describe the design, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd73a71489c572ecba1eed92db0a392
https://pubmed.ncbi.nlm.nih.gov/33507227
https://pubmed.ncbi.nlm.nih.gov/33507227
Publikováno v:
JAMA Oncology. 7:1579
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc795614c6f1a2af3d4c7174728a452
https://doi.org/10.1001/jamaoncol.2021.3344
https://doi.org/10.1001/jamaoncol.2021.3344
Autor:
Luis P Del Carpio, Joseph C. Del Paggio, Agustí Barnadas, Eitan Amir, Arnoud J. Templeton, Ariadna Tibau, Alberto Ocaña, Christopher M. Booth, Consolación Molto
Publikováno v:
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Universitat Pompeu Fabra
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Universitat Pompeu Fabra
Background: It is uncertain whether drugs approved by the US Food and Drug Administration (FDA) have clinically meaningful benefit as determined by validated scales such as the European Society for Medical Oncology Magnitude of Clinical Benefit Scale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4967a9f411745dbfd443b767e7c7ba57
https://doi.org/10.1093/jnci/djx232
https://doi.org/10.1093/jnci/djx232