Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Joseph C K Leung"'
Autor:
Wai Han Yiu, Dickson W L Wong, Loretta Y Y Chan, Joseph C K Leung, Kwok Wah Chan, Hui Yao Lan, Kar Neng Lai, Sydney C W Tang
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88894 (2014)
Tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose (HG) in human proximal tubular epithelial cells (PTEC). Since the kallikrein-kinin system (KKS) has been linked to cellular inflammatory p
Externí odkaz:
https://doaj.org/article/461f80e8003f413c9fc02858f4d40d16
Autor:
Hao Jia Wu, Wai Han Yiu, Rui Xi Li, Dickson W L Wong, Joseph C K Leung, Loretta Y Y Chan, Yuelin Zhang, Qizhou Lian, Miao Lin, Hung Fat Tse, Kar Neng Lai, Sydney C W Tang
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90883 (2014)
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood. As renal prognosis in CKD is
Externí odkaz:
https://doaj.org/article/57419aea3cdf445aa9cabd84538a4876
Autor:
Hongyu Li, Joseph C. K. Leung, Wai Han Yiu, Loretta Y. Y. Chan, Bin Li, Sarah W. Y. Lok, Rui Xue, Yixin Zou, Kar Neng Lai, Sydney C. W. Tang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-15 (2022)
Abstract Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates mitochondrial dysfunction i
Externí odkaz:
https://doaj.org/article/82f9885eca8b4c88bf8be3fca5551bed
Autor:
Wai Han Yiu, Kam Wa Chan, Loretta Y. Y. Chan, Joseph C. K. Leung, Kar Neng Lai, Sydney C. W. Tang
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase involved in signal transduction in a variety of immune responses. It has been demonstrated that Syk plays a pathogenic role in orchestrating inflammatory responses and cell proliferation
Externí odkaz:
https://doaj.org/article/a4a3de2399374b749e791af0560293a5
Publikováno v:
Advances in oto-rhino-laryngology. 72
IgA nephropathy (IgAN) is characterized by mesangial deposition of pathogenic polymeric IgA1 with rare deposits in the tubular epithelial cells (TEC). Recently, a novel mechanism involving a glomerulopodocytictubular cross-talk in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3356884e6ecdde1aae9b7a191e24275
https://pubmed.ncbi.nlm.nih.gov/21865686
https://pubmed.ncbi.nlm.nih.gov/21865686
Publikováno v:
Advances in oto-rhino-laryngology. 72
Synthesis of aberrant IgA molecules as the key pathogenetic mechanism of immunoglobulin A nephropathy (IgAN) apparently forms a potential scientific rationale for applying immunomodulatory agents in the treatment of IgAN. There is evidence that corti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db352de12e512572ad1c6968da3e9f65
https://pubmed.ncbi.nlm.nih.gov/21865687
https://pubmed.ncbi.nlm.nih.gov/21865687
Publikováno v:
Contributions to nephrology. 170
In chronic glomerulopathic disease, renal function correlates more with the degree oftubulointerstitial injury than that of the glomerular lesions. Proteinuria may be one of the pathologic links between these two intrarenal compartments. It is appare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b914e3f23602e9667b550ce62dae491
https://pubmed.ncbi.nlm.nih.gov/21659765
https://pubmed.ncbi.nlm.nih.gov/21659765
Publikováno v:
Contributions to nephrology. 170
Emerging evidence suggests a role of the kallikrein-kinin system (KKS) in the pathogenesis of diabetic nephropathy (DN). Tissue kallikrein 1 is a member of the tissue kallikrein family that is mainly responsible for the generation of kinins, and brad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69f6c46b71a7acf6aadf34da095c7dca
https://pubmed.ncbi.nlm.nih.gov/21659767
https://pubmed.ncbi.nlm.nih.gov/21659767
Publikováno v:
Contributions to nephrology. 170
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in developed countries where type 2 diabetes mellitus has reached epidemic proportions. Although the exact pathogenesis of DN is not fully understood and is likely diverse in nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3c8c68890e269aff1d33c1e424769a9
https://pubmed.ncbi.nlm.nih.gov/21659766
https://pubmed.ncbi.nlm.nih.gov/21659766
Autor:
Sydney C W, Tang, Loretta Y Y, Chan, Joseph C K, Leung, Amy S, Cheng, Miao, Lin, Hui Y, Lan, Kar N, Lai
Publikováno v:
Nephrology (Carlton, Vic.). 16(4)
The authors recently showed that advanced glycation end-products (AGE) in the form of glycated albumin (GA) upregulated renal tubular expression of interleukin (IL)-8 and soluble intercellular adhesion molecule-1 (sICAM-1), but not other important cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb6ecdcf0a4c024993068ec8e488634c
https://pubmed.ncbi.nlm.nih.gov/21143336
https://pubmed.ncbi.nlm.nih.gov/21143336