Výsledky vyhledávání - "Joseph C Godoy"

Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes

Autor: Anna Schwarz, Jan M. Schilling, Ingrid R. Niesman, Georgios Kararigas, Anna R. Busija, Nancy D. Dalton, Joseph C. Godoy, John C. Drummond, Alice E. Zemljic-Harpf, Erika A. Alvarez, Hemal H. Patel, David M. Roth, Adam Kassan

Publikováno v: The FASEB Journal. 33:1209-1225

Statins, which reduce LDL-cholesterol by inhibition of 3-hydroxy-3-methylglutaryl–coenzyme A reductase, are among the most widely prescribed drugs. Skeletal myopathy is a known statin-induced adverse effect associated with mitochondrial changes. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e4fdad358c04272bf15370c3e9cfdd
https://doi.org/10.1096/fj.201800876r

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Differential Effects of Hydrophilic versus Lipophilic Statins on RhoA Kinase Inhibition and Membrane Stability in Cardiac Myocytes

Autor: Alice E. Zemljic-Harpf, Elizabeth Asfaw, Joseph C. Godoy, Jan M. Schilling, Erika A. Alvarez, Anna Schwarz, Hemal H. Patel, Nancy D. Dalton

Publikováno v: The FASEB Journal. 29

Statins are among the most prescribed drugs worldwide. By inhibiting mevalonate synthesis statins inhibit protein prenylation and thereby may reduce RhoA kinase activity. Cardiac overexpression of ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::281361525175fc183ad09e658f0f5775
https://doi.org/10.1096/fasebj.29.1_supplement.801.5

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Abstract 320: Long-term Atorvastatin, But Not Pravastatin, Treatment Leads To Repressed Mitochondrial Gene Expression And Altered Cardiac Ultrastructure

Autor: Alice Zemljic-Harpf, Joseph C Godoy, Ingrid R Niesman, Jan M Schilling, Anna Schwarz, Elizabeth K Asfaw, Erika A Alvarez, Nancy D Dalton, Piyush M Patel, Brian P Head, John C Drummond, David M Roth, Georgios Kararigas, Hemal H Patel

Publikováno v: Circulation Research. 115

Statins reduce low-density lipoprotein cholesterol (LDL-C) and decrease cardiovascular events. Although statins are generally well tolerated, the FDA warns that statins may induce skeletal muscle side effects, cognitive changes and increased fasting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fea85794f7f0d16e1eefe9d879ec7146
https://doi.org/10.1161/res.115.suppl_1.320

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Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry

Autor: Ingrid R. Niesman, David M. Roth, Victoria B. Risbrough, Weihua Cui, Alice E. Zemljic-Harpf, Brian P. Head, Hemal H. Patel, Jan M. Schilling, Piyush M. Patel, John C. Drummond, Joseph C. Godoy

Membrane/lipid rafts (MLR) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in the biosynthesis of mevalonic, a precursor to ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d289d9e694aa7f288b53f6409e3485f
https://escholarship.org/uc/item/2tt0n3ps

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Long‐term atorvastatin treatment inhibited pro‐survival signaling, reduced mitochondrial function and altered ultrastructural integrity in cardiac myocytes (1095.6)

Autor: Elizabeth Asfaw, Joseph C. Godoy, Ingrid R. Niesman, Jan M. Schilling, Alice E. Zemljic-Harpf, Hemal H. Patel, Erika A. Alvarez, Nancy Dalton, Anna Schwarz, Adam Kassan

Publikováno v: The FASEB Journal. 28

Introduction: Statins are widely used to lower low-density lipoprotein cholesterol (LDL-C) for prevention of cardiovascular disease. The FDA warns that statins may induce skeletal muscle side effects. Skeletal muscle biopsies from patients with stati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::765826405148e70d6bb838173a4a117b
https://doi.org/10.1096/fasebj.28.1_supplement.1095.6

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Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes

Autor: Joseph C. Godoy, Andrea A. Domenighetti, Elizabeth K. Asfaw, Anna R. Busija, Robert S. Ross, Oleksandr Platoshyn, Alice E. Zemljic-Harpf

Publikováno v: Journal of cell science. 127(Pt 5)

Vinculin (Vcl) links actin filaments to integrin and cadherin-based cellular junctions. Zonula occludens-1 (ZO-1) binds connexin-43 (Cx43), cadherin and actin. Vcl and ZO-1 anchor the actin cytoskeleton to the sarcolemma. Since loss of Vcl from cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9ee4c5c09278cc01a42de318d8a62d
https://pubmed.ncbi.nlm.nih.gov/24413171

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Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes

Autor: Alice E. Zemljic-Harpf, Anna R. Busija, Oleksandr Platoshyn, Robert S. Ross, Andrea A. Domenighetti, Elizabeth K. Asfaw, Joseph C. Godoy

Publikováno v: Development. 141:e708-e708

Vinculin (Vcl) links actin filaments to integrin- and cadherin-based cellular junctions. Zonula occludens-1 (ZO-1, also known as TJP1) binds connexin-43 (Cx43, also known as GJA1), cadherin and actin. Vcl and ZO-1 anchor the actin cytoskeleton to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1adb7c321a1260065bb7bcc2dacd430
https://doi.org/10.1242/dev.109553

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Sulfonation pathway inhibitors block reactivation of latent HIV-1

Autor: Celsa A. Spina, James W. Bruce, John A. T. Young, Amey Mukim, Jeffrey P. Murry, Justine Swann, Joseph C. Godoy, Paul Ahlquist, Vicente Planelles, Alberto Bosque

Publikováno v: Virology. :1-12

Long-lived pools of latently infected cells are a significant barrier to the development of a cure for HIV-1 infection. A better understanding of the mechanisms of reactivation from latency is needed to facilitate the development of novel therapies t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b54fbdad30592c7f1869b1ec9e5c9d

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