Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joseph C Galley"'
Autor:
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyocytes are no
Externí odkaz:
https://doaj.org/article/347f7b78e498476bb1cd8f897c890698
Autor:
Joseph C. Galley, Megan P. Miller, Subramaniam Sanker, Mingjun Liu, Iraida Sharina, Emil Martin, Delphine Gomez, Adam C. Straub
Publikováno v:
Am J Physiol Heart Circ Physiol
Nitric oxide (NO) binds soluble guanylyl cyclase β (sGCβ) to produce cGMP and relax vascular smooth muscle cells (SMCs) needed for vasodilation. Although the regulation of NO-stimulated sGC activity has been well characterized at the posttranslatio
Autor:
Scott A. Hahn, Joseph C Galley, Brittany G Durgin, Sean D. Stocker, Edwin K. Jackson, Megan P. Miller, Adam C. Straub
Publikováno v:
British Journal of Pharmacology. 179:2490-2504
Background and purpose Reduced renal blood flow triggers activation of the renin-angiotensin-aldosterone system (RAAS) leading to renovascular hypertension. Renal vascular smooth muscle expression of the NO receptor, soluble GC (sGC), modulates the v
Autor:
Joseph C, Galley, Shubhnita, Singh, Wanessa M C, Awata, Juliano V, Alves, Thiago, Bruder-Nascimento
Publikováno v:
Biochemical Pharmacology. 206:115324
Obesity and hypertension are intimately linked due to the various ways that the important cell types such as vascular smooth muscle cells (VSMC), endothelial cells (EC), immune cells, and adipocytes, communicate with one another to contribute to thes
Autor:
Adam C. Straub, Heidi M Schmidt, Joseph C Galley, Shuai Yuan, Atinuke M. Dosunmu-Ogunbi, Katherine C. Wood
Publikováno v:
Hypertension
The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and arterioles have evolved a series of highly orchestrated cell-cell communication mechanisms bet
Autor:
Brittany G Durgin, Megan Miller, Edwin K. Jackson, Joseph C Galley, Scott Hahn, Sean D. Stocker, Adam C. Straub
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Reduced renal blood flow triggers activation of the renin-angiotensin-aldosterone system (RAAS) leading to renovascular hypertension. Renal vascular smooth muscle expression of the nitric oxide (NO) receptor, soluble guanylyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f999376d050f711b2ef3cc855174e4
https://doi.org/10.22541/au.159986538.84326499
https://doi.org/10.22541/au.159986538.84326499
Abstract P114: Foxo4 Regulates Vascular Smooth Muscle Soluble Guanylyl Cyclase Expression Expression
Publikováno v:
Hypertension. 76
Soluble guanylyl cyclase (sGC) modulator drugs may offer a new approach to attenuate hypertension by enhancing vasorelaxation through production of cGMP. Loss of sGC leads to impaired vasorelaxation and hypertension, however the mechanisms that regul
Publikováno v:
Hypertension. 74
Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity leading to elevated cyclic guanosine 3′, 5′-monophosphate (cGMP) and vascular smooth muscle relaxation. Downregulation of sGC expression attenuates vascular dilation and contrib
Autor:
Scott A. Hahn, Shuai Yuan, Joseph C Galley, Brittany G Durgin, Katherine C. Wood, Adam C. Straub, Megan P. Miller
Publikováno v:
Molecular Pharmacology
Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellular cyclic guanosine 3',5'-monophosphate (cGMP) and subsequent vascular smooth muscle relaxation. It is known that downregulation of sGC expression at
Autor:
Helene M. Altmann, Nolan T Carew, Dennis M. McNamara, Joseph C Galley, Scott A. Hahn, Sruti Shiva, Megan P. Miller, Adam C. Straub
Publikováno v:
Circulation Research. 123
Oxidative stress contributes to the adverse pathophysiology of cardiac remodeling in heart failure. During oxidative stress, hemoprotein heme-iron can be oxidized, often altering the function of these proteins. We previously reported that cytochrome