Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Joseph C Arezzo"'
Autor:
Michelle W Antoine, Xiaoxia Zhu, Marianne Dieterich, Thomas Brandt, Sarath Vijayakumar, Nicholas McKeehan, Joseph C Arezzo, R Suzanne Zukin, David A Borkholder, Sherri M Jones, Robert D Frisina, Jean M Hébert
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2002988 (2018)
How asymmetries in motor behavior become established normally or atypically in mammals remains unclear. An established model for motor asymmetry that is conserved across mammals can be obtained by experimentally inducing asymmetric striatal dopamine
Externí odkaz:
https://doaj.org/article/585efff9782148cebaf22e2e325004ed
Autor:
April D Lake, Kevin Holsapple, Tanya McDonnell, Joseph C Arezzo, Ricardo Ramirez, Lindsay Gamelin, Mei Yu, Dylan Glatt, Ryan Dick, Xiaodong Xie, Regina Choy, Guofeng Cheng, Chin H Tay, Anne Chester, Darryl Kato, Leigh Ann Burns-Naas
Publikováno v:
Toxicological Sciences. 186:298-308
The nonclinical safety profile of GS-8873, a hepatitis B virus RNA transcript inhibitor was evaluated in rat and monkey 13-week toxicity studies with 8-week recovery phases. Vehicle or GS-8873 was dosed orally for 13 weeks at 2, 6, 20, and 60 mg/kg/d
Autor:
Jamie K. DaSilva, Joseph C. Arezzo
Publikováno v:
Toxicologic pathology. 48(1)
The peripheral nervous system (PNS) is subject to a wide range of structural and functional insults including direct damage to axons, loss of myelin, and progressive deficits in saltatory conduction. Drugs that damage the PNS often result in neuropat
Autor:
Audrey Sanfacon, Emmanuel Boulay, Eric Troncy, Michael V. Accardi, Joseph C. Arezzo, Michelle Dubuc Mageau, Mylene Pouliot, Simon Authier, Stephanie Mignault Goulet, Wendy Tan, Dominique Paquette
Publikováno v:
Journal of pharmacological and toxicological methods. 97
Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (inter-spec
Autor:
William M. Valentine, Brad Bolon, Ingrid D. Pardo, Bernard S. Jortner, Mark T. Butt, Alok K. Sharma, Deepa B. Rao, Joseph C. Arezzo
Publikováno v:
Toxicologic pathology. 46(8)
Peripheral nervous system (PNS) toxicity is a frequent adverse effect encountered in patients treated with certain therapeutics (e.g., antiretroviral drugs, cancer chemotherapeutics), in occupational workers exposed to industrial chemicals (e.g., sol
Publikováno v:
Diabetes Care. 39:596-602
OBJECTIVE Lack of C-peptide in type 1 diabetes may be an important contributing factor in the development of microvascular complications. Replacement of native C-peptide has been shown to exert a beneficial influence on peripheral nerve function in t
Autor:
Aziz Shaibani, Michael Polydefkis, Marshall Nash, Kate Bradshaw, Roderick Junor, Joseph C. Arezzo, Robert Gordon, Vera Bril
Publikováno v:
Journal of the Peripheral Nervous System. 20:363-371
We examined the efficacy and safety of ranirestat in patients with diabetic sensorimotor polyneuropathy (DSPN). Patients (18-75 years) with stable type 1/2 diabetes mellitus and DSPN were eligible for this global, double-blind, phase II/III study (Cl
Autor:
Donald C. Manning, Robert J. Schwartzman, R. Norman Harden, Guillermo M. Alexander, Alyse Cooper, Joseph C. Arezzo, Srinivasa N. Raja, Anne Louise Oaklander, Richard Rauck
Publikováno v:
The Journal of Pain. 15(12):1366-1376
Complex regional pain syndrome (CRPS) is a potentially debilitating chronic pain syndrome with a poorly understood but likely neuroimmune/multifactorial pathophysiology associated with axonal injury. Based on the potential contribution of proinflamma
Autor:
Yanneve Rolland, Claude Godbout, Hui Ding, Alexandre Bramoullé, Michel O. Steinmetz, Rolf A. Brekken, Patrick G. Harran, Sami Chaaban, Thomas M. Wilkie, Ozhan Ocal, Natacha Olieric, Peter M. Siegel, Anne Roulston, Joseph C. Arezzo, Matthew G. Annis, Gary J. Brouhard, Cynthia Bernier, Mark A. Hancock, Cecilia Rocha, Anita Hall, Andrea E. Prota, Joseph Tcherkezian, Michal Wieczorek, George Zogopoulos, Gordon C. Shore
Publikováno v:
Science translational medicine, vol 8, iss 365
Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the stability of microtubules, causing cell death in mitosis. We describe DZ-2384, a preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38a6fb17c4299685199025dd72f9ddc
https://escholarship.org/uc/item/9dr6h535
https://escholarship.org/uc/item/9dr6h535
Autor:
Emmanuel Boulay, Audrey Sanfacon, Dominique Paquette, Michelle Dubuc Mageau, Mylene Pouliot, Eric Troncy, Wendy Tan, Michael V. Accardi, Joseph C. Arezzo, Simon Authier, Stephanie Mignault Goulet
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106611
Seizures are amongst the most frequent neurological issues encountered in pre-clinical safety testing. The objective was to characterize EEG morphologies and premonitory signs in drug-induced seizures in preclinical species. A comparative (inter-spec