Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joseph C, Cheng"'
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76593 (2013)
The tumor suppressor PTEN is now understood to regulate cellular processes at the cytoplasmic membrane, where it classically regulates PI3K signaling, as well as in the nucleus where multiple roles in controlling cell cycle and genome stability have
Externí odkaz:
https://doaj.org/article/dab14f17c0624768883c18e56fb294fc
Autor:
Barry J. Keane, Caroline Yount, Bill X. Wu, Anne M. Bartlett, Alicja Bielawska, Joseph C. Cheng, Michael T. Smith, E. Ellen Jones, Ping Lu, Katherine Young, James S. Norris, Aiping Bai, David T. Marshall, Thomas E. Keane, Thomas H. Beckham, S. Tucker Marrison, Kent Armeson, Xiang Liu, Richard R. Drake
Publikováno v:
Journal of Clinical Investigation. 123:4344-4358
Escape of prostate cancer (PCa) cells from ionizing radiation–induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate, on signal trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fda314fbdc632076d126717693f5a7
https://doi.org/10.1172/jci64791
https://doi.org/10.1172/jci64791
Publikováno v:
International journal of stem cell research and therapy
Mesenchymal stem cells (MSCs) are a multipotent cell population acquired most prominently from bone marrow with the capacity to differentiate into osteoblasts, chondrocytes, adipocytes, and others. MSCs demonstrate the capacity to home to sites of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be66d0a815d5a820ce815079f41ed403
https://pubmed.ncbi.nlm.nih.gov/27275017
https://pubmed.ncbi.nlm.nih.gov/27275017
Autor:
Stanley Hoffman, Yusuf A. Hannun, Thomas H. Beckham, Dan Zhao, Xiang Liu, Ping Lu, Kent Armeson, Xiaoyi Zhang, Angen Liu, Tucker Marrison, Lorianne S. Turner, Joseph C. Cheng
Publikováno v:
International Journal of Cancer. 131:2034-2043
Invasiveness is one of the key features of aggressive prostate cancer, however our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002f1cb7d25039826c52350c360126f9
https://doi.org/10.1002/ijc.27480
https://doi.org/10.1002/ijc.27480
Autor:
Gyorgy Petrovics, Jun Hou, Yixue Li, Zoltan Szallasi, Jesse M. Fox, Heng-Cheng Hu, Shiv Srivastava, Clifton L. Dalgard, Yongmei Chen, Yingjie Song, Joel T. Moncur, Cara Schafer, Jacob Kagan, Guo-Ping Zhao, Wendy Wang, Sudhir Srivastava, Isabell A. Sesterhenn, Inger L. Rosner, Qingyu Xiao, Reinhard Ebner, Matthew D. Wilkerson, Joseph C. Cheng, Yuan Ji, Hua Li, Matthew L. Freedman, Gauthaman Sukumar, Shyh-Han Tan, Yidi Sun, Kevin Babcock, Albert Dobi, Jennifer Cullen, Denise Young, Lakshmi Ravindranath
Publikováno v:
Cancer Research. 78:5352-5352
Background: Distinct biology of prostate cancer (CaP) among men of different races and ethnicities have been recently highlighted. Along these lines higher frequencies of the most common CaP gene alterations, ERG proto-oncogene activation and deletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3752b9631ad18da3f27c1609865298eb
https://doi.org/10.1158/1538-7445.am2018-5352
https://doi.org/10.1158/1538-7445.am2018-5352
Autor:
Thomas H. Beckham, Lorianne S. Turner, Xiang Liu, Saeed Elojeimy, James S. Norris, Joseph C. Cheng, Stanley Hoffman
Publikováno v:
Expert Opinion on Therapeutic Targets. 14:529-539
Ceramide accumulation has been shown to be a conserved mechanism of apoptosis initiation in normal physiological processes as well as in response to cancer treatments. Therefore, it is unsurprising that many cancers develop aberrations of sphingolipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190c636c16e9e846f48453ebd5b07abf
https://doi.org/10.1517/14728221003752768
https://doi.org/10.1517/14728221003752768
Autor:
Thomas H. Beckham, Saeed Elojeimy, James S. Norris, Lorianne S. Turner, Xiang Liu, Alicja Bielawska, Joseph C. Cheng, Yusuf A. Hannun, Thomas E. Keane
Publikováno v:
Expert Opinion on Therapeutic Targets. 13:1449-1458
Bioactive sphingolipids, such as ceramide, sphingosine, and sphingosine-1-phosphate are known bio-effector molecules which play important roles in various aspects of cancer biology including cell proliferation, growth arrest, apoptosis, metastasis, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2accba515aee8e3f00de8ed7d356b564
https://doi.org/10.1517/14728220903357512
https://doi.org/10.1517/14728220903357512
Autor:
David H. Holman, John McKillop, Jian-Yun Dong, Terrence A. Day, Saeed Elojeimy, Yusuf A. Hannun, Ahmed El-Zawahry, James S. Norris, Lorianne S. Turner, Alicja Bielawska, Joseph C. Cheng, Ayman Mahdy, Xiang Liu, William D Meacham, Jonathan Y Cheng, Antonio F. Saad
Publikováno v:
Molecular Therapy. 15:1259-1263
Head and neck squamous cell cancers (HNSCC) are particularly aggressive and are resistant to many forms of treatment. Ceramide metabolism has been shown to play an important role in cancer progression and cancer resistance to therapy in many tumor mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9aaf300e960c846a05d60d6c8ef619
https://doi.org/10.1038/sj.mt.6300167
https://doi.org/10.1038/sj.mt.6300167
Publikováno v:
Current psychiatry reports. 17(7)
The neuroanatomical correlates of human sexual desire, arousal, and behavior have been characterized in recent years with functional brain imaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET). Here, we br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903e534b117a23a259e737d7acc13b3c
https://pubmed.ncbi.nlm.nih.gov/25980508
https://pubmed.ncbi.nlm.nih.gov/25980508
Autor:
David H. Holman, Joseph C. Cheng, Ahmed El-Zawahry, Maristella Villani, Saeed Elojeimy, Youssef H. Zeidan, Yusuf A. Hannun, Ayman Mahdy, James S. Norris, Alicja Bielwaska, Xiang Liu
Publikováno v:
FEBS Letters. 580:4751-4756
Treatment of different cancer cell lines with desipramine induced a time- and dose-dependent downregulation of acid ceramidase. Desipramine’s effect on acid ceramidase appeared specific for amphiphilic agents (desipramine, chlorpromazine, and chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4290775791f07767aca05ebf2999769
https://doi.org/10.1016/j.febslet.2006.07.071
https://doi.org/10.1016/j.febslet.2006.07.071