Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joseph Brunner"'
Autor:
Shalom Siebert, Joseph Brunner, Abigail Serda, Bahram H. Arjmandi, Joseph Munoz, Elizabeth Foley, Kelli George, Lauren Ormsbee, Neda S. Akhavan, Holly Clarke
Publikováno v:
Curr Dev Nutr
OBJECTIVES: Inflammation has been shown to play a role in a variety of disease states including osteoporosis and cardiovascular disease. Leaky gut has been implicated in contributing to these inflammatory states. The purpose of this study was to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58f9cc74b8dafb4370093f4fc39ece3
https://europepmc.org/articles/PMC7257055/
https://europepmc.org/articles/PMC7257055/
Autor:
Malin Hultcrantz, Thomas Ling, Emma C. Scott, Laurie Eliason, Julie Byrne, Joanna Opalinska, Wei He, Pavandeep Ghataorhe, Joseph Brunner, Roxanne C. Jewell, David M. Kleinman, Astrid McKeown
Publikováno v:
Blood. 138:1645-1645
Introduction: Belantamab mafodotin is a first-in-class, monomethyl auristatin F (MMAF)-containing, B-cell maturation antigen (BCMA)-directed antibody-drug conjugate (ADC) that is approved in the United States and European Union for adult patients wit
Autor:
Christina N. DiMarco, Anthony L. Gotter, Alan T. Savitz, Joanne Stevens, Joseph G. Bruno, Tamara D. Cabalu, John J. Renger, Jason W. Skudlarek, Pamela L. Tannenbaum, Paul J. Coleman, Scott D. Kuduk, Joseph Brunner, Susan L. Garson, Christopher J. Winrow, Julie A. O'Brien, Charles M. Harrell, Mark H. Pausch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2488-2492
Antagonism of orexin receptors has shown clinical efficacy as a novel paradigm for the treatment of insomnia and related disorders. Herein, molecules related to the dual orexin receptor antagonist filorexant were transformed into compounds that were
Autor:
Christopher J. Winrow, Joanne Stevens, Anthony J. Roecker, Charles M. Harrell, Alan T. Savitz, W. Peter Wuelfing, Kerim Babaoglu, Jason W. Skudlarek, Paul J. Coleman, Steven V. Fox, Christina Ng Dimarco, Pamela L. Tannenbaum, Scott D. Kuduk, Susan L. Garson, Joseph G. Bruno, Joseph Brunner, John J. Renger, Tamara D. Cabalu, Anthony L. Gotter, Mark A. Pausch, Julie A. O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(6)
In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the di
Autor:
Pamela L. Tannenbaum, Scott D. Kuduk, Tamara D. Cabalu, Joseph Brunner, Mark A. Pausch, Christina N. Di Marco, Joseph G. Bruno, Paul J. Coleman, Anthony L. Gotter, John J. Renger, Joanne Stevens, Jason W. Skudlarek, Christopher J. Winrow, Julie A. O'Brien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1784-1789
Analogs of the dual orexin receptor antagonist filorexant were prepared. Replacement of the ether linkage proved highly sensitive toward modification with an acetylene linkage providing compounds with the best in vitro and in vivo potency profiles.
Publikováno v:
The Journal of Cell Biology
We have systematically analyzed the molecular environment of the signal sequence of a growing secretory protein from Escherichia coli using a stage- and site-specific cross-linking approach. Immediately after emerging from the ribosome, the signal se
Autor:
Sandra Deitermann, Joseph Brunner, Matthias Müller, Meriem Alami, Gottfried Eisner, Hans-Georg Koch, Iris Lüke
Publikováno v:
Molecular Cell. 12(4):937-946
The twin-arginine translocation (Tat) machinery of the Escherichia coli inner membrane is dedicated to the export of proteins harboring a conserved SRRxFLK motif in their signal sequence. TatA, TatB, and TatC are the functionally essential constituen
Autor:
Corinne M. ten Hagen-Jongman, Joen Luirink, Amanda Raine, Bauke Oudega, Ronald S. Ullers, N. Harms, Edith N.G. Houben, Måns Ehrenberg, Joseph Brunner
Publikováno v:
Journal of Cell Biology, 161, 679-684. Rockefeller University Press
Ullers, R S, Houben, E N G, Raine, A, ten Hagen-Jongman ten, C M, Ehrenberg, M, Brunner, J, Oudega, B, Harms, N & Luirink, S 2003, ' Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome ', Journal of Cell Biology, vol. 161, pp. 679-684 . https://doi.org/10.1083/jcb.200302130
The Journal of Cell Biology
Ullers, R S, Houben, E N G, Raine, A, ten Hagen-Jongman ten, C M, Ehrenberg, M, Brunner, J, Oudega, B, Harms, N & Luirink, S 2003, ' Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome ', Journal of Cell Biology, vol. 161, pp. 679-684 . https://doi.org/10.1083/jcb.200302130
The Journal of Cell Biology
As newly synthesized polypeptides emerge from the ribosome, they interact with chaperones and targeting factors that assist in folding and targeting to the proper location in the cell. In Escherichia coli, the chaperone trigger factor (TF) binds to n
Autor:
Leslie M. Shaw, Christopher J. Winrow, M A Kling, Anthony L. Gotter, LM Chahine, NG Hatcher, P Gehrman, Joseph Brunner, Nalaka S. Gooneratne, J Kalinina, Lihang Yao
Publikováno v:
Sleep. 40:A103-A103
Autor:
Marina Pitto, Massimo Masserini, Anita Ferraretto, Daniela Ravasi, Paola Palestini, Joseph Brunner
Publikováno v:
Glycoconjugate Journal. 17:215-222
A new photoactivable, radioactive derivative of ganglioside GM1 has been utilized to assess lipid distribution in the caveolae bilayer, taking advantage of the ability of the glycolipid, endogenous or exogenously added, to concentrate within this mem