Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Joseph Bondy-Denomy"'
Autor:
Rachael E. Workman, Marie J. Stoltzfus, Nicholas C. Keith, Chad W. Euler, Joseph Bondy-Denomy, Joshua W. Modell
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113849- (2024)
Summary: CRISPR-Cas immune systems provide bacteria with adaptive immunity against bacteriophages, but they are often transcriptionally repressed to mitigate auto-immunity. In some cases, CRISPR-Cas expression increases in response to a phage infecti
Externí odkaz:
https://doaj.org/article/8f1d1d1e943a4010b6fec27b0be2675a
Autor:
Andrea Fossati, Deepto Mozumdar, Claire Kokontis, Melissa Mèndez-Moran, Eliza Nieweglowska, Adrian Pelin, Yuping Li, Baron Guo, Nevan J. Krogan, David A. Agard, Joseph Bondy-Denomy, Danielle L. Swaney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Host-pathogen interactions are pivotal in regulating establishment, progression, and outcome of an infection. While affinity-purification mass spectrometry has become instrumental in characterizing such interactions, it suffers from limitati
Externí odkaz:
https://doaj.org/article/bfb0742bdc28451aa8144fcd925343ed
Autor:
Polina Muzyukina, Anton Shkaruta, Noemi M. Guzman, Jessica Andreani, Adair L. Borges, Joseph Bondy-Denomy, Anna Maikova, Ekaterina Semenova, Konstantin Severinov, Olga Soutourina
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTCRISPR-Cas systems provide prokaryotic hosts with adaptive immunity against mobile genetic elements. Many bacteriophages encode anti-CRISPR (Acr) proteins that inhibit host defense. The identification of Acr proteins is challenging due to the
Externí odkaz:
https://doaj.org/article/71128c6ead1449c1a691bf90e99cb7e8
Autor:
Eliza S. Nieweglowska, Axel F. Brilot, Melissa Méndez-Moran, Claire Kokontis, Minkyung Baek, Junrui Li, Yifan Cheng, David Baker, Joseph Bondy-Denomy, David A. Agard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA. Using cryoEM, the authors show that the 2D crystal enclosing this so-called phage nucleus is an assembly of
Externí odkaz:
https://doaj.org/article/f7a9df2988ef437aa0a60e5c599bd823
Autor:
Rafael Pinilla-Redondo, Saadlee Shehreen, Nicole D. Marino, Robert D. Fagerlund, Chris M. Brown, Søren J. Sørensen, Peter C. Fineran, Joseph Bondy-Denomy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Mobile genetic elements have evolved anti-CRISPR (Acr) proteins to bypass the immunity provided by prokaryotic CRISPR–Cas systems. Here, the authors identify 11 type I Acrs encoded on mobile genetic elements, and show that acr loci neighborhoods ca
Externí odkaz:
https://doaj.org/article/d9475332a4d84a3d8ba6e1f2654da4ac
Autor:
Ayal B. Gussow, Allyson E. Park, Adair L. Borges, Sergey A. Shmakov, Kira S. Makarova, Yuri I. Wolf, Joseph Bondy-Denomy, Eugene V. Koonin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
CRISPR-Cas is a host adaptive immunity system and viruses harbor diverse anti-CRISPR proteins (Acrs). Here, the authors develop a random forest machine-learning approach to predict Acrs, identifying 2500 candidate Acr families, which expand the curre
Externí odkaz:
https://doaj.org/article/ebeb6afe4a8347318cf5044cb7657ab8
Autor:
Hannah N. Taylor, Eric Laderman, Matt Armbrust, Thomson Hallmark, Dylan Keiser, Joseph Bondy-Denomy, Ryan N. Jackson
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Type IV CRISPR systems encode CRISPR associated (Cas)-like proteins that combine with small RNAs to form multi-subunit ribonucleoprotein complexes. However, the lack of Cas nucleases, integrases, and other genetic features commonly observed in most C
Externí odkaz:
https://doaj.org/article/6adc247da6b74c48bb94bd6c1e9ca6e2
Autor:
Muneaki Nakamura, Prashanth Srinivasan, Michael Chavez, Matthew A. Carter, Antonia A. Dominguez, Marie La Russa, Matthew B. Lau, Timothy R. Abbott, Xiaoshu Xu, Dehua Zhao, Yuchen Gao, Nathan H. Kipniss, Christina D. Smolke, Joseph Bondy-Denomy, Lei S. Qi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Anti-CRISPR proteins derived from phage can abrogate CRISPR activity. The authors repurpose these molecules for demonstrating genomic write-protection and pre-programmed gene expression circuits.
Externí odkaz:
https://doaj.org/article/4ee1c4c14f3b4f9ea9f6a31062906453
Autor:
Yogesh Hooda, Mohammad S I Sajib, Hafizur Rahman, Stephen P Luby, Joseph Bondy-Denomy, Mathuram Santosham, Jason R Andrews, Samir K Saha, Senjuti Saha
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007868 (2019)
BackgroundWith the rise in fluoroquinolone-resistant Salmonella Typhi and the recent emergence of ceftriaxone resistance, azithromycin is one of the last oral drugs available against typhoid for which resistance is uncommon. Its increasing use, speci
Externí odkaz:
https://doaj.org/article/15390f016068492b872ff44f68297f2e
Autor:
Karen L. Maxwell, Bianca Garcia, Joseph Bondy-Denomy, Diane Bona, Yurima Hidalgo-Reyes, Alan R. Davidson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-5 (2016)
Recently, anti-CRISPR proteins have been identified. Here, the authors report the solution structure of one of these proteins, and use mutational analysis to provide some insight into its function.
Externí odkaz:
https://doaj.org/article/9b215a192e9d4782b44e3653cdf27d05