Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Joseph Bloom"'
Autor:
Yurie Sato-Yamada, Amy Strickland, Yo Sasaki, Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Charcot-Marie-Tooth disease type 2A (CMT2A) is an axonal neuropathy caused by mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial abnormalities, but the mechanism underlying the axonal pathology is unknown. Steri
Externí odkaz:
https://doaj.org/article/a22016f1de27458fb151f9e0cd2dd534
Autor:
María del Mar Maldonado, Gabriela Rosado-González, Joseph Bloom, Jorge Duconge, Jean F. Ruiz-Calderón, Eliud Hernández-O’Farrill, Cornelis Vlaar, José F. Rodríguez-Orengo, Suranganie Dharmawardhane
Publikováno v:
ACS Omega, Vol 4, Iss 19, Pp 17981-17989 (2019)
Externí odkaz:
https://doaj.org/article/372433e0c63343658e826b365e127300
Autor:
Jarline Encarnación-Medina, Rosa I. Rodríguez-Cotto, Joseph Bloom-Oquendo, Mario G. Ortiz-Martínez, Jorge Duconge, Braulio Jiménez-Vélez
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
ATP-binding cassette subfamily C (ABCC) genes code for phase III metabolism proteins that translocate xenobiotic (e.g., particulate matter 2.5 (PM2.5)) and drug metabolites outside the cells. IL-6 secretion is related with the activation of the ABCC
Externí odkaz:
https://doaj.org/article/1f07ed383a4b4f919fb9387596a05744
Autor:
Krystal M. Butler-Fernández, Zulma Ramos, Adela M. Francis-Malavé, Joseph Bloom, Suranganie Dharmawardhane, Eliud Hernández
Publikováno v:
Molecules, Vol 24, Iss 15, p 2686 (2019)
In this study, a new series of N-alkyl-3,6-dibromocarbazole and N-alkyl-5-bromoindole derivatives have been synthesized and evaluated in vitro as anti-cancer and anti-migration agents. Cytotoxic and anti-migratory effects of these compounds were eval
Externí odkaz:
https://doaj.org/article/a6f8012de97b4932b7c7c69e7a39d400
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-15 (2022)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is autoinhibited, but single amino acid changes can abolish autoinhibition leading to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620457f64816dcecff573e162e599ec1
https://doaj.org/article/d65223ac517c430493d55dc723359e47
https://doaj.org/article/d65223ac517c430493d55dc723359e47
Autor:
Anna Quaglieri, Joseph Bloom, Aaron Triantafyllidis, Bradley Green, Mark R. Condina, Paula Burton Ngov, Giuseppe Infusini, Andrew I. Webb
Data processing is essential to reliably generate knowledge from proteomics studies. The complexity of the proteomics data, as well as the ability of research teams to adopt complex analysis pipelines, have proven to be an obstacle to effective colla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::572dcef0df1eff7c7e172666a6250b56
https://doi.org/10.1101/2022.12.12.517480
https://doi.org/10.1101/2022.12.12.517480
Autor:
A. Joseph Bloom, Amber R. Hackett, Amy Strickland, Yurie Yamada, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt
Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS) and disruption of SC cellular metabolism leads to demyelination and axon degeneration, both symptoms of peripheral neuropathies. The lactate shu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::931b28bc504caaaa78c0a6a61a0ce473
https://doi.org/10.1101/2022.06.29.497865
https://doi.org/10.1101/2022.06.29.497865
Autor:
Yurie Sato-Yamada, Amy Strickland, Yo Sasaki, Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Charcot-Marie-Tooth disease (CMT) type 2A is an axonal neuropathy caused by mutations in the mitofusin 2 (MFN2) gene. MFN2 mutations result in profound mitochondrial abnormalities, but the mechanism underlying axonal pathology is unknown. SARM1, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c09ef29321c303cfae5271badabc612
https://doi.org/10.1101/2022.05.17.492364
https://doi.org/10.1101/2022.05.17.492364
Autor:
Kelsey L. Krus, Amy Strickland, Yurie Yamada, Laura Devault, Robert E. Schmidt, A. Joseph Bloom, Jeffrey Milbrandt, Aaron DiAntonio
Publikováno v:
Cell reports. 39(13)
TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most patients with amyotrophic lateral sclerosis (ALS). To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we generated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2813a830dfb68a91121f259679668b13
https://pubmed.ncbi.nlm.nih.gov/35767949
https://pubmed.ncbi.nlm.nih.gov/35767949
Autor:
Caitlin B. Dingwall, Amy Strickland, Sabrina W. Yum, Aldrin K. Yim, Jian Zhu, Peter L. Wang, Yurie Yamada, Robert E. Schmidt, Yo Sasaki, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Publikováno v:
The Journal of clinical investigation. 132(23)
Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. We identified two rare NMNAT2 missense variants in two brothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048e9dba47546b82cc1b144d333b0777
https://pubmed.ncbi.nlm.nih.gov/36287209
https://pubmed.ncbi.nlm.nih.gov/36287209