Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joseph Beyer"'
Autor:
Cleopatra Kozlowski, Surinder Jeet, Joseph Beyer, Steve Guerrero, Justin Lesch, Xiaoting Wang, Jason DeVoss, Lauri Diehl
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 3, Pp 855-865 (2013)
SUMMARY The DSS (dextran sulfate sodium) model of colitis is a mouse model of inflammatory bowel disease. Microscopic symptoms include loss of crypt cells from the gut lining and infiltration of inflammatory cells into the colon. An experienced patho
Externí odkaz:
https://doaj.org/article/f04fd995d61144f7b0aac470577268be
Autor:
Deepak Sampath, Bobbi McCray, Mark Zak, Hirdesh Uppal, Tanja S. Zabka, Trung Nguyen, Mara A. Kauss, Jatinder Singh, Bianca M. Liederer, Joseph Beyer, Cynthia Farman, Jason Oeh, Yang Xiao, Dinah Misner, Peter S. Dragovich, Tori Lin, Preeti Dhawan, Nghi La, Thomas O'Brien
Publikováno v:
Toxicological Sciences. 144:163-172
Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein with intra- and extra-cellular functions as an enzyme, cytokine, growth factor, and hormone. NAMPT is of interest for oncology, because it catalyzes the rate-limiting step in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1872702026d023c0885bf33184e4e8be
https://doi.org/10.1093/toxsci/kfu268
https://doi.org/10.1093/toxsci/kfu268
Autor:
Michael W. Leach, Jennifer L. Rojko, Deborah Finco, M. Benjamin Hock, Joseph Beyer, James B. Rottman
Publikováno v:
Toxicologic Pathology. 42:293-300
This continuing education course was designed to provide an overview of the immunologic mechanisms involved in immunogenicity and hypersensitivity reactions following administration of biologics in nonclinical toxicity studies, the methods used to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e128c9afed7faa6ec85e0a4f43cd877
https://doi.org/10.1177/0192623313510987
https://doi.org/10.1177/0192623313510987
Autor:
Justin Lesch, Lauri Diehl, Jason DeVoss, Joseph Beyer, Steve Guerrero, Cleopatra Kozlowski, Surinder Jeet, Xiaoting Wang
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 3, Pp 855-865 (2013)
Disease Models & Mechanisms
Disease Models & Mechanisms
Summary The DSS (dextran sulfate sodium) model of colitis is a mouse model of inflammatory bowel disease. Microscopic symptoms include loss of crypt cells from the gut lining and infiltration of inflammatory cells into the colon. An experienced patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7069eef41008cada7351e07554a1929a
http://dmm.biologists.org/content/6/3/855
http://dmm.biologists.org/content/6/3/855
Autor:
Thomas P. Brown, Joseph Beyer, David B. Lewis, Daniel Weinstock, Noel Dybdal, Mark Collinge, George A. Parker
Publikováno v:
Toxicologic Pathology. 38:1111-1117
Developmental immunotoxicity (DIT) has gained attention with the recognition that environmental chemicals can potentially affect the developing immune system and the incidence of childhood allergic diseases. Preclinical safety assessment of pharmaceu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e3a4fadc486d6a69058f6442cbc0dbe
https://doi.org/10.1177/0192623310382436
https://doi.org/10.1177/0192623310382436
Autor:
Gerhard F. Weinbauer, Anu Vaidyanathan, Banmeet S. Anand, Steve Eppler, Joseph Beyer, Kathleen McKeever
Publikováno v:
Toxicological Sciences. 119:116-125
Rituximab is a chimeric murine/human-engineered immunoglobulin (Ig) G1 anti-CD20 monoclonal antibody, selectively depleting CD20-expressing cells in peripheral blood and lymphoid tissues. As part of the rituximab registration-enabling program for rhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe03e6cf67cd63f3e737ab5d0167c43
https://doi.org/10.1093/toxsci/kfq316
https://doi.org/10.1093/toxsci/kfq316
Autor:
Charles F Wu, Joseph Beyer
This technical note provides an overview of the senior housing industry in the United States. There were 40 million seniors in America in 2010, and that number was expected to double by 2050. Seniors would make up 1 in every five Americans. This note
Autor:
Charles F Wu, Joseph Beyer
The case describes several issues for the continuum of senior care alternatives for residents and developers. What motivates seniors to leave their homesteads for much smaller spaces? How can they afford to do so? What are the physical as well as ope
Autor:
Suhasini Iyer, Sherry Yeh, Kathy Howell, Mercedesz Balazs, Laura DeForge, Jeffrey Thompson, Allen J. Ebens, Zhonghua Lin, Christine Ambrose, Maya Leabman, Germaine Fuh, Shiming Ye, Wyne P. Lee, Qinglin Ou, Thomas Gelzleichter, Chingwei V. Lee, Wei Yu Lin, Dimitry M. Danilenko, Melissa A. Starovasnik, Joseph Beyer, Qian Gong, Dhaya Seshasayee, Flavius Martin, Jean Shu, Eric Suto
Publikováno v:
Blood. 110:3959-3967
Removal of pathogenic B lymphocytes by depletion of monoclonal antibodies (mAbs) or deprivation of B-cell survival factors has demonstrated clinical benefit in both oncologic and immunologic diseases. Partial clinical responses and emerging data demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097d141204a369c61e0bbe2e44212d6a
https://doi.org/10.1182/blood-2007-04-088088
https://doi.org/10.1182/blood-2007-04-088088
Autor:
Krishna P. Allamneni, Amrita V. Kamath, Siao Ping Tsai, Gu Zhang, Jacqueline M. Tarrant, Jessica Couch, Maciej Paluch, Ryan Cook, Gary Cain, Nicholas Lewin-Koh, Minhong Yan, Christina L. Zuch de Zafra, Jayme Franklin, Sarajane Ross, Philip E. Hass, Joseph Beyer, Jane Ruppel, Priyanka Gupta, Sharon Yee, John B. Ridgway
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(6)
Purpose: Although agents targeting Delta-like ligand 4 (DLL4) have shown great promise for angiogenesis-based cancer therapy, findings in recent studies have raised serious safety concerns. To further evaluate the potential for therapeutic targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8bbb2fa5127325a6941a3699cf5e53
https://pubmed.ncbi.nlm.nih.gov/26589434
https://pubmed.ncbi.nlm.nih.gov/26589434