Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Joseph Bass"'
Autor:
Nina C. Lund, Yetunde Kayode, Melanie R. McReynolds, Deanna C. Clemmer, Hannah Hudson, Isabelle Clerc, Hee-Kyung Hong, Jason M. Brenchley, Joseph Bass, Richard T. D’Aquila, Harry E. Taylor
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
mTOR limits the activation of an inflammatory gene response in monocytes. Inhibitors of mTOR enhance NF-κB-driven transcription in LPS-stimulated monocytes while depleting NAD+ through effects on the salvage pathway.
Externí odkaz:
https://doaj.org/article/6764010621db4decbc08cfa607d9a1f7
Autor:
Yuanchao Ye, Marwa Abu El Haija, Reine Obeid, Hussein Herz, Liping Tian, Benjamin Linden, Yi Chu, Deng Fu Guo, Daniel C. Levine, Jonathan Cedernaes, Kamal Rahmouni, Joseph Bass, Mohamad Mokadem
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
The molecular clock machinery regulates several homeostatic rhythms, including glucose metabolism. We previously demonstrated that Roux-en-Y gastric bypass (RYGB) has a weight-independent effect on glucose homeostasis and transiently reduces food int
Externí odkaz:
https://doaj.org/article/c85266c72aed4208b90efdcdf61f2ca5
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/a3d839ae6f394a8c8cddb7fde4b89443
Autor:
Michelle Wintzinger, Manoj Panta, Karen Miz, Ashok D. Prabakaran, Hima Bindu Durumutla, Michelle Sargent, Clara Bien Peek, Joseph Bass, Jeffery D. Molkentin, Mattia Quattrocelli
Publikováno v:
Molecular Metabolism, Vol 62, Iss , Pp 101528- (2022)
Objective: Mitochondrial capacity is critical to adapt the high energy demand of the heart to circadian oscillations and diseased states. Glucocorticoids regulate the circadian cycle of energy metabolism, but little is known about how circadian timin
Externí odkaz:
https://doaj.org/article/3e3a56fc99d948a191446c1e145190ae
Autor:
Biliana Marcheva, Benjamin J Weidemann, Akihiko Taguchi, Mark Perelis, Kathryn Moynihan Ramsey, Marsha V Newman, Yumiko Kobayashi, Chiaki Omura, Jocelyn E Manning Fox, Haopeng Lin, Patrick E Macdonald, Joseph Bass
Publikováno v:
eLife, Vol 11 (2022)
The mammalian circadian clock drives daily oscillations in physiology and behavior through an autoregulatory transcription feedback loop present in central and peripheral cells. Ablation of the core clock within the endocrine pancreas of adult animal
Externí odkaz:
https://doaj.org/article/4ba877e38361469da7c8d4a16351a710
Autor:
Rahul Rai, Asish K. Ghosh, Mesut Eren, Alexander R. Mackie, Daniel C. Levine, So-Youn Kim, Jonathan Cedernaes, Veronica Ramirez, Daniele Procissi, Layton H. Smith, Teresa K. Woodruff, Joseph Bass, Douglas E. Vaughan
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1471-1480 (2017)
Summary: Aging drives the occurrence of numerous diseases, including cardiovascular disease (CVD). Recent studies indicate that blood from young mice reduces age-associated pathologies. However, the “anti-aging” factors in juvenile circulation re
Externí odkaz:
https://doaj.org/article/e57763e528694b2495fe9be8e1900ad1
Autor:
Jonathan Cedernaes, Joseph Bass
Publikováno v:
eLife, Vol 5 (2016)
Neurons in the brainstem are the input for a neural circuit that integrates nutrient signals to control feeding behavior.
Externí odkaz:
https://doaj.org/article/6117b075740b454eabc9cd68c91c4ad5
Autor:
Kazuhiro Shimomura, Vivek Kumar, Nobuya Koike, Tae-Kyung Kim, Jason Chong, Ethan D Buhr, Andrew R Whiteley, Sharon S Low, Chiaki Omura, Deborah Fenner, Joseph R Owens, Marc Richards, Seung-Hee Yoo, Hee-Kyung Hong, Martha H Vitaterna, Joseph Bass, Mathew T Pletcher, Tim Wiltshire, John Hogenesch, Phillip L Lowrey, Joseph S Takahashi
Publikováno v:
eLife, Vol 2 (2013)
Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockΔ19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We m
Externí odkaz:
https://doaj.org/article/d769ffe1cd9845f0911f69fd98294374
Autor:
Chunlei Wu, David L Delano, Nico Mitro, Stephen V Su, Jeff Janes, Phillip McClurg, Serge Batalov, Genevieve L Welch, Jie Zhang, Anthony P Orth, John R Walker, Richard J Glynne, Michael P Cooke, Joseph S Takahashi, Kazuhiro Shimomura, Akira Kohsaka, Joseph Bass, Enrique Saez, Tim Wiltshire, Andrew I Su
Publikováno v:
PLoS Genetics, Vol 4, Iss 5, p e1000070 (2008)
Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene expression levels across genetic mapping populations. The
Externí odkaz:
https://doaj.org/article/fa80e29c71a0416faaa85e8ff6d947a7
Autor:
Daniel C. Levine, Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, Alexandra G. Wright, Meredith A. Sommars, Yumiko Kobayashi, Biliana Marcheva, Peng Gao, Olga R. Ilkayeva, Chiaki Omura, Kathryn M. Ramsey, Christopher B. Newgard, Grant D. Barish, Clara Bien Peek, Navdeep S. Chandel, Milan Mrksich, Joseph Bass
Publikováno v:
Nature Metabolism
In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. Although NAD+ also p