Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Joseph Barbosa"'
Publikováno v:
Repositório Institucional da FIOCRUZFundação Oswaldo CruzFIOCRUZ.
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Externí odkaz:
https://www.arca.fiocruz.br/handle/icict/6143
Autor:
Nelson Papavero, Dante Martins Teixeira, Christian Fausto Moraes dos Santos, José Lima de Figueiredo, Rafael Dias da Silva Campos
Publikováno v:
Fauna e flora do Brasil (especialmente do Mato Grosso) segundo Joseph Barbosa de Sáa (1769)
Joseph Barbosa de Saa (? – 1775), mais conhecido por seus escritos sobre a historia do estado do Mato Grosso, Brasil, completou em 1769 um volumoso (408 folios) e erudito manuscrito, intitulado “Dialogos geograficos, coronologicos, polliticos e n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::431fc47869ae0eff2fe8c604ec13af62
https://doi.org/10.11606/9788575062173
https://doi.org/10.11606/9788575062173
Autor:
Alan Wilson, Jason P. Healy, Robert Brommage, Xiaolian Xu, Qiang Han, Praveen K. Pabba, Kenneth G. Carson, Gardyan Michael Walter, James M. Schmidt, Andrea Y. Thompson, Ross Mabon, Kristen M. Terranova, Joseph Barbosa, James E. Tarver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1184-1187
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylester
Autor:
Simon D.P. Baugh, Praveen K. Pabba, Joseph Barbosa, Eric Coulter, Urvi Desai, Jason P. Gay, Suma Gopinathan, Qiang Han, Rajee Hari, S. David Kimball, Huy V. Nguyen, Chi-You Ni, David R. Powell, Arian Smith, Kristen M. Terranova, Alan Wilson, Xuan-Chuan Yu, Victoria K. Lombardo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3836-3839
The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the inda
Autor:
Cynthia Anne Fink, Michael Alan Green, Thomas H. Lanthorn, Alan Wilson, G. Greg Zipp, Xuan-Chuan Yu, Katerina V. Savelieva, Amr Nouraldeen, Joseph Barbosa, Kristen M. Terranova, S. David Kimball
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3886-3890
The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the
Publikováno v:
International Journal of People-Oriented Programming. 3:75-90
The notion of wheel spinning, students getting stuck in the mastery learning cycle of an ITS without mastering the skill, is an emerging issue. Although wheel spinning has been analyzed, there has been little work in understanding what factors underl
Autor:
Wei He, Kenneth G. Carson, Victoria K. Lombardo, Praveen K. Pabba, James E. Tarver, Qiang Han, Alan Wilson, James M. Schmidt, Robert Brommage, Gardyan Michael Walter, Andrea Y. Thompson, Joseph Barbosa
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(6)
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highl
Autor:
Qingyun Liu, Weimei Sun, Amr Nouraldeen, Lawrence F. Courtney, Alan Wilson, Suman Layek, Marianne Carlsen, Sean Yu, Mark S. Bednarz, Zhong Lai, Ann Marie Digeorge-Foushee, Tamas Oravecz, Jerry A. Taylor, Traci Smith, Haiming Zhang, Liam Moran, Jonathan C. Swaffield, Debra Bruce, Jill Hazelwood, Simon D.P. Baugh, David J. Augeri, Emily O’Neill, Joseph Barbosa, Kristen M. Terranova, Suma Gopinathan, Gardyan Michael Walter, Huy Van Nguyen, S. David Kimball, Jeffrey T. Bagdanoff, Jack Yan, Theodore C. Jessop, Michael S. Donoviel, Qinghong Fu, Jeffrey A. Kramer, Alan Main, James E. Tarver, Kenneth G. Carson
Publikováno v:
Journal of Medicinal Chemistry. 52:3941-3953
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL catalyzes the irreversible decomposition
Autor:
James Kempson, Joseph Barbosa, Steven G. Nadler, Karen Stebbins, Andrew Watson, Deborah Lee, Junqing Guo, William J. Pitts, John H. Dodd, Murray McKinnon, Joel C. Barrish, Marianne Carlsen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1935-1938
A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to
Publikováno v:
LAK
Traditional practices of spacing and expanding retrieval practices have typically fixed their spacing intervals to one or few predefined schedules [5, 7]. Few have explored the advantages of using personalized expanding intervals and scheduling syste