Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Joseph B Lillegard"'
Autor:
Robert A Kaiser, Daniel F Carlson, Kari L Allen, Dennis A Webster, Caitlin J VanLith, Clara T Nicolas, Lori G Hillin, Yue Yu, Catherine W Kaiser, William R Wahoff, Raymond D Hickey, Adrienne L Watson, Shelley R Winn, Beat Thöny, Douglas R Kern, Cary O Harding, Joseph B Lillegard
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245831 (2021)
Phenylketonuria (PKU) is a metabolic disorder whereby phenylalanine metabolism is deficient due to allelic variations in the gene for phenylalanine hydroxylase (PAH). There is no cure for PKU other than orthotopic liver transplantation, and the stand
Externí odkaz:
https://doaj.org/article/f3e73823f1454455a713448bd5ccf3f7
Autor:
Clara T. Nicolas, Caitlin J. VanLith, Raymond D. Hickey, Zeji Du, Lori G. Hillin, Rebekah M. Guthman, William J. Cao, Benjamin Haugo, Annika Lillegard, Diya Roy, Aditya Bhagwate, Daniel O’Brien, Jean-Pierre Kocher, Robert A. Kaiser, Stephen J. Russell, Joseph B. Lillegard
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Hereditary tyrosinemia type 1 (HT1) is an inborn error of metabolism caused by a deficiency in fumarylacetoacetate hydrolase (FAH). Here, the authors show in an animal model that HT1 can be treated via in vivo portal vein administration of a lentivir
Externí odkaz:
https://doaj.org/article/e139874638f64ab69e044b4aab48bfa5
Autor:
Clara T. Nicolas, Robert A. Kaiser, Raymond D. Hickey, Kari L. Allen, Zeji Du, Caitlin J. VanLith, Rebekah M. Guthman, Bruce Amiot, Lukkana Suksanpaisan, Bing Han, Maria Giovanna Francipane, Amin Cheikhi, Huailei Jiang, Aditya Bansal, Mukesh K. Pandey, Ishan Garg, Val Lowe, Aditya Bhagwate, Daniel O’Brien, Jean-Pierre A. Kocher, Timothy R. DeGrado, Scott L. Nyberg, Eric Lagasse, Joseph B. Lillegard
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 738-750 (2020)
The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-
Externí odkaz:
https://doaj.org/article/8ffcb39c8aed4257acfa76228d16a408
Autor:
Raymond D. Hickey, Clara T. Nicolas, Kari Allen, Shennen Mao, Faysal Elgilani, Jaime Glorioso, Bruce Amiot, Caitlin VanLith, Rebekah Guthman, Zeji Du, Harvey Chen, Cary O. Harding, Robert A. Kaiser, Scott L. Nyberg, Joseph B. Lillegard
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Orthotopic liver transplantation remains the only curative therapy for inborn errors of metabolism. Given the tremendous success for primary immunodeficiencies using ex-vivo gene therapy with lentiviral vectors, there is great interest in developing
Externí odkaz:
https://doaj.org/article/28fa4edd0f0d436b83ea7d18ccf3489b
Publikováno v:
Journal of Perinatology. 42:856-859
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff4a248d3b030dd63f599db52dc4b9f
https://doi.org/10.1038/s41372-022-01317-5
https://doi.org/10.1038/s41372-022-01317-5
Autor:
Joseph B, Lillegard, Stephanie A, Eyerly-Webb, David A, Watson, Mert Ozan, Bahtiyar, Kelly A, Bennett, Stephen P, Emery, Allan J, Fisher, Ruth B, Goldstein, William H, Goodnight, Foong-Yen, Lim, Laurence B, McCullough, Ueli, Moehrlen, Julie S, Moldenhauer, Anita J, Moon-Grady, Rodrigo, Ruano, Daniel W, Skupski, Marjorie C, Treadwell, KuoJen, Tsao, Amy J, Wagner, Michael V, Zaretsky
Publikováno v:
Fetal Diagnosis and Therapy. 49:117-124
Introduction: Uterine incision based on the placental location in open maternal-fetal surgery (OMFS) has never been evaluated in regard to maternal or fetal outcomes. Objective: The aim of this study was to investigate whether an anterior placenta wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07615171eed7ba7ff0dfe951a6357185
https://doi.org/10.1159/000521379
https://doi.org/10.1159/000521379
Autor:
Michael Martinez, Nicholas D. Weber, William Cao, Lori G Hillin, Robert A. Kaiser, Anne Douar, Kari L. Allen, Joseph B. Lillegard, Caitlin J. VanLith, Rafael Aldabe, Laia Trigueros-Motos, Gloria González-Aseguinolaza
Publikováno v:
Journal of Inherited Metabolic Disease. 44:1369-1381
Phenylketonuria (PKU) is the most common inborn error of metabolism of the liver, and results from mutations of both alleles of the phenylalanine hydroxylase gene (PAH). As such, it is a suitable target for gene therapy via gene delivery with a recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23c76d8f40370a31f5d41f8847fe54e
https://doi.org/10.1002/jimd.12392
https://doi.org/10.1002/jimd.12392
Autor:
Raymond D. Hickey, Shennen A. Mao, Jaime Glorioso, Joseph B. Lillegard, James E. Fisher, Bruce Amiot, Piero Rinaldo, Cary O. Harding, Ronald Marler, Milton J. Finegold, Markus Grompe, Scott L. Nyberg
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 144-153 (2014)
Hereditary tyrosinemia type I (HT1) is caused by deficiency in fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the last step of tyrosine metabolism. The most severe form of the disease presents acutely during infancy, and is characteriz
Externí odkaz:
https://doaj.org/article/cd4acf6a1a674b389a583745d498c1c3
Autor:
Bjorn I. Engstrom, Saul Snowise, Vinit Amin, Lisa Howley, Joseph B. Lillegard, James L. Fisher
Publikováno v:
Fetal Diagnosis and Therapy. 48:560-566
Placental chorangiomas can cause a high-output fetal state and increase neonatal morbidity and mortality. There is a paucity of data published describing the optimal treatment of these cases, and methods for occlusion to date include placement of vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95087a494f162dff35d0767c37e063e
https://doi.org/10.1159/000516625
https://doi.org/10.1159/000516625
Autor:
Bruce Amiot, Timothy R. DeGrado, Amin Cheikhi, Caitlin J. VanLith, Val J. Lowe, Aditya Bansal, Robert A. Kaiser, Mukesh K. Pandey, Daniel R. O'Brien, Zeji Du, Huailei Jiang, Raymond D. Hickey, Rebekah M. Guthman, Lukkana Suksanpaisan, Scott L. Nyberg, Jean Pierre A. Kocher, Aditya Bhagwate, Ishan Garg, Maria Giovanna Francipane, Eric Lagasse, Clara T. Nicolas, Joseph B. Lillegard, Bing Han, Kari L. Allen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 738-750 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594a12ff39203dc0dfd7fad66b0d80a6
http://www.sciencedirect.com/science/article/pii/S2329050120301583
http://www.sciencedirect.com/science/article/pii/S2329050120301583