The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket

Autor: Anu Thomas, Chidananda Sulli, Edgar Davidson, Eli Berdougo, Morganne Phillips, Bridget A. Puffer, Cheryl Paes, Benjamin J. Doranz, Joseph B. Rucker

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Although bitter taste receptors (TAS2Rs) are important for human health, little is known of the determinants of ligand specificity. TAS2Rs such as TAS2R16 help define gustatory perception and dietary preferences that ultimately influence hum

Externí odkaz: https://doaj.org/article/12f45ce1b6b94a4e81f404c14a6ac2b5

Abstract 317: Isolation of highly selective antibodies against claudin 18.2 for the treatment of solid tumors

Autor: Brad Screnci, Trevor Barnes, Kristen Shema, Rebecca Rimkunas, Shruthi Kannan, Tim Phillips, Carmen Navia, Charles Azuelos, Tom Charpentier, Jennifer Houtmann, Lisa Miller, Lewis J. Stafford, Benjamin J. Doranz, Joseph B. Rucker, Ross Chambers

Publikováno v: Cancer Research. 82:317-317

Monoclonal antibodies (MAbs) are a well-established treatment approach in oncology and other diseases. Nevertheless, many multipass membrane proteins are largely inaccessible as antibody targets due to their poor expression, membrane-dependent struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29e5a2fdaee7e481f65c8ce1e940a67b
https://doi.org/10.1158/1538-7445.am2022-317

A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease.

Autor: Suganya Selvarajah, Nicole R Sexton, Kristen M Kahle, Rachel H Fong, Kimberly-Anne Mattia, Joy Gardner, Kai Lu, Nathan M Liss, Beatriz Salvador, David F Tucker, Trevor Barnes, Manu Mabila, Xiangdong Zhou, Giada Rossini, Joseph B Rucker, David Avram Sanders, Andreas Suhrbier, Vittorio Sambri, Alain Michault, Marcus O Muench, Benjamin J Doranz, Graham Simmons

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 9, p e2423 (2013)

The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccin

Externí odkaz: https://doaj.org/article/8169a058b1b3485d96513f63bdd55e09

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Autor: Joseph B. Rucker, Dominique Schols, Martine J. Smit, Chris de Graaf, Marta Arimont, Tom Van Loy, Jordi Doijen, Kurt Vermeire, Vladimir Bobkov, Hans de Haard, Rebecca Rimkunas, Tracy M. Handel, Chunxia Zhao, Theo Verrips, Anneleen Van Hout, Raimond Heukers, Alex Klarenbeek, Bas van der Woning

Publikováno v: Biochemical Pharmacology, 158, 402-412. Elsevier Inc.
Van Hout, A, Klarenbeek, A, Bobkov, V, Doijen, J, Arimont, M, Zhao, C, Heukers, R, Rimkunas, R, de Graaf, C, Verrips, T, van der Woning, B, de Haard, H, Rucker, J B, Vermeire, K, Handel, T, Van Loy, T, Smit, M J & Schols, D 2018, ' CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry ', Biochemical Pharmacology, vol. 158, pp. 402-412 . https://doi.org/10.1016/j.bcp.2018.10.015
Biochemical Pharmacology

The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target. Drug side ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828ace8b04eff60baa196efa2022c0ac
https://research.vu.nl/en/publications/17c930fd-9064-4010-ab85-cad54737cf29

Origin and Differential Selection of Allelic Variation at TAS2R16 Associated with Salicin Bitter Taste Sensitivity in Africa

Autor: Sarah A. Tishkoff, Jibril Hirbo, Sabah A. Omar, Dennis Drayna, Gurja Belay, Dawit Woldemeskel, Alessia Ranciaro, Simon Thompson, Alain Froment, Renata Rawlings-Goss, Joseph B. Rucker, Daniel Zinshteyn, Paul A. S. Breslin, Jean-Marie Bodo, Thomas B. Nyambo, Michael Campbell

Publikováno v: Molecular Biology and Evolution. 31:288-302

Bitter taste perception influences human nutrition and health, and the genetic variation underlying this trait may play a role in disease susceptibility. To better understand the genetic architecture and patterns of phenotypic variability of bitter t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cddd14302fa9a5d17d8fda025b6c05
https://doi.org/10.1093/molbev/mst211