Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Joseph Avruch"'
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101209- (2021)
Background: Type 2 diabetes (T2D) is a common metabolic disease. Variants in human IGF2 mRNA binding protein 2 (IMP2/IGF2BP2) are associated with increased risk of T2D. IMP2 contributes to T2D susceptibility primarily through effects on insulin secre
Externí odkaz:
https://doaj.org/article/52cb0d0d9b944780b1461b1adeed5bcd
Autor:
William W. Greenwald, Joshua Chiou, Jian Yan, Yunjiang Qiu, Ning Dai, Allen Wang, Naoki Nariai, Anthony Aylward, Jee Yun Han, Nikita Kadakia, Laura Regue, Mei-Lin Okino, Frauke Drees, Dana Kramer, Nicholas Vinckier, Liliana Minichiello, David Gorkin, Joseph Avruch, Kelly A. Frazer, Maike Sander, Bing Ren, Kyle J. Gaulton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Risk loci for type 2 diabetes (T2D) reside in pancreatic islet enhancers. Here, the authors generate high-resolution maps of islet chromatin conformation using Hi-C which they combine with ATAC-seq and ChIP-seq data to annotate candidate target genes
Externí odkaz:
https://doaj.org/article/2308d1b8b59042bb8921a23b1acf35fe
Autor:
Luke H. Chao, Joseph Avruch
Publikováno v:
F1000Research, Vol 8 (2019)
The mechanistic target of rapamycin (MTOR) is a giant protein kinase that, together with the accessory proteins Raptor and mLst8, forms a complex of over 1 MDa known as MTOR complex 1 (MTORC1). MTORC1, through its protein kinase activity, controls th
Externí odkaz:
https://doaj.org/article/fc25990c5bf342a493f3daff71317623
Autor:
Faisal Alsufyani, Hamid Mattoo, Dawang Zhou, Annaiah Cariappa, Denille Van Buren, Hanno Hock, Joseph Avruch, Shiv Pillai
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The Mst1 and 2 cytosolic serine/threonine protein kinases are the mammalian orthologs of the Drosophila Hippo protein. Mst1 has been shown previously to participate in T-cell and B-cell trafficking and the migration of lymphocytes into secondary lymp
Externí odkaz:
https://doaj.org/article/176c734b83664256a6ee66754465d269
Autor:
Julien Fitamant, Filippos Kottakis, Samira Benhamouche, Helen S. Tian, Nicolas Chuvin, Christine A. Parachoniak, Julia M. Nagle, Rushika M. Perera, Marjorie Lapouge, Vikram Deshpande, Andrew X. Zhu, Albert Lai, Bosun Min, Yujin Hoshida, Joseph Avruch, Daniela Sia, Genís Campreciós, Andrea I. McClatchey, Josep M. Llovet, David Morrissey, Lakshmi Raj, Nabeel Bardeesy
Publikováno v:
Cell Reports, Vol 10, Iss 10, Pp 1692-1707 (2015)
Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. YAP functions as a rheostat in maint
Externí odkaz:
https://doaj.org/article/0668dfdac5754c879ffbfed4d6e834b3
Publikováno v:
eLife, Vol 6 (2017)
The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2 is amplified and overexpressed in many human cancers, accompanied by a poorer prognosis. Mice lacking IMP2 exhibit a longer lifespan and a reduced tumor burden at old age.
Externí odkaz:
https://doaj.org/article/f2b71f8d4f9d43a1af9220ea97af6c8c
Autor:
Hongtan Wu, Yubo Xiao, Shihao Zhang, Suyuan Ji, Luyao Wei, Fuqin Fan, Jing Geng, Jing Tian, Xiufeng Sun, Funiu Qin, Changnan Jin, Jianjun Lin, Zhen-Yu Yin, Ting Zhang, Lianzhong Luo, Yang Li, Siyang Song, Sheng-Cai Lin, Xianming Deng, Fernando Camargo, Joseph Avruch, Lanfen Chen, Dawang Zhou
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1663-1677 (2013)
The transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds to the
Externí odkaz:
https://doaj.org/article/1e54d500f5d0467985130d2f25e9acde
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0116096 (2015)
mTOR complex1, the major regulator of mRNA translation in all eukaryotic cells, is strongly activated in most cancers. We performed a genome-wide RNAi screen in a human cancer cell line, seeking genes that regulate S6 phosphorylation, readout of mTOR
Externí odkaz:
https://doaj.org/article/0914a99ae4f0494db30ba4fcc3d4d575
Autor:
Denise L Faustman, Limei Wang, Yoshiaki Okubo, Douglas Burger, Liqin Ban, Guotong Man, Hui Zheng, David Schoenfeld, Richard Pompei, Joseph Avruch, David M Nathan
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41756 (2012)
No targeted immunotherapies reverse type 1 diabetes in humans. However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it stimulates innate immunity by inducing the
Externí odkaz:
https://doaj.org/article/96d04219e8c9416c86676f37811dc485
Excessive adiposity is the main cause of obesity and type two diabetes (T2D). Variants in human IMP2/IGF2BP2 gene are associated with increased risk of T2D. However, little is known about its role in adipogenesis and in insulin resistance. Here, we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7b1b6fb94a13b4159762377e057633
https://doi.org/10.2337/figshare.21298485
https://doi.org/10.2337/figshare.21298485
