Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joseph Armstrong Martin"'
Autor:
Joseph Armstrong Martin, JH Merrett, Jürg Fässler, Jane Ives, Glyn Williams, Philipp Ermert, Daniel Obrecht, Klaus Klumpp, Kevin E. B. Parkes
Publikováno v:
Journal of Medicinal Chemistry. 46:1153-1164
Data from both our own and literature studies of the biochemistry and inhibition of influenza virus endonuclease was combined with data on the mechanism of action and the likely active site mechanism to propose a pharmacophore. The pharmacophore was
Autor:
Christopher S. Frampton, Paul L. Coe, W.Anthony Thomas, Ian W. A. Whitcombe, Peter Maunder, Joseph Armstrong Martin
Publikováno v:
Journal of Fluorine Chemistry. 115:13-20
The fluorination of (+)- chiro -inositol with SF 4 /HF under moderate conditions affords a single product studied by 1 H and 19 F and 13 C NMR spectroscopy. These have been fully assigned with the aid of other physical techniques and compared with a
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2759-2762
The cyclohexane analogues 3 and 4 of the piperidine carboxamide 1 have been synthesized. The trans isomer 3 is more potent than the hydroxyethylamine 1 versus HIV-1 proteinase, while the cis isomer 4 is less potent.
Publikováno v:
Journal of Fluorine Chemistry. 58:87-92
Myo-inositol was treated with a mixture of sulphur tetrafluoride and anhydrous hydrofluoric acid to yield a novel compound, the cyclic sulphite ester of 2β,3β-difluoro-7-oxabicyclo[2,2,1]heptane- 5α,6α-diol. The structural assignment and possible
Autor:
I. Najera, Sophie Le Pogam, Graham Maile, Hobbs Christopher John, JH Merrett, Steven Swallow, Carl Laxton, Julie Hang, Rene Devos, Stewart J. Baker, Han Ma, Keshab Sarma, Julian Symons, Klaus Klumpp, David Bernard Smith, Vincent Leveque, David R. Vesey, Peter Blomgren, Mark D. Smith, Arkadius Pichota, Joseph Armstrong Martin, W.R. Jiang, Caroline Granycome, Nick Cammack
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(9)
A series of 4'-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV) RNA replication in cell culture. The most potent and non-cytotoxic derivative was compound 28 (4'-azidocytidine, R1479) wi
Autor:
Kevin E. B. Parkes, David J. Bushnell, Philippe Wong Kai-In, Andrew C. Freeman, Julie E Cansfield, JH Merrett, Ian R Johns, Stephen J. Dunsdon, Stewart J. Baker, Joseph Armstrong Martin, Mark Holland, Heather Simmonite, Andrea Walmsley, Robert Wilson Lambert, Gareth John Thomas, Elizabeth Keech, Richard A. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
A series of carboxamide derivatives of 5′-amino-2′,5′-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase). The most potent compounds were derived from xanthene, thioxanthene and dihydroanthra
Autor:
A Angell, Christopher McGuigan, Felice Daverio, David Smith, M. R. Kelleher, Joseph Armstrong Martin, Klaus Klumpp, G Luoni, S. Le Pogam, S. Mulready, Costantino Congiatu, Perrone Plinio, I. Najera, Sonal Rajyaguru, Vincent Leveque
Publikováno v:
Antiviral Research. 74:A36-A37
We report the application of our phosphoramidate ProTide technology to various 4′-substituted ribonucleoside analogues, designed as potential inhibitors of hepatitis C virus (HCV) (Fig. 1). Thus, ProTides were prepared from 4′-azidouridine (AZU),
Publisher Summary This chapter focuses on inhibitors of HIV Proteinase. X-ray crystallographic structures of HIV proteinase complexed with a diverse range of inhibitors have now been published. Despite large differences in the structures of the bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b366557821abdeb8b11fa25a0dadd7b
https://doi.org/10.1016/s0079-6468(08)70455-7
https://doi.org/10.1016/s0079-6468(08)70455-7
Autor:
Mark D. Smith, David Smith, Tatiana Maltseva, Elena V. Usova, I. Najera, C. Brown, Joseph Armstrong Martin, Han Ma, W.R. Jiang, Staffan Eriksson, S. Le Pogam, Vincent Leveque, Genadiy Kalayanov, Anna Winqvist, Nils Gunnar Johansson, Nick Cammack, Klaus Klumpp, Christian Sund
Publikováno v:
Journal of Hepatology. 46:S190
Autor:
W.Anthony Thomas, Christopher S. Frampton, Ian W. A. Whitcombe, Joseph Armstrong Martin, Peter Maunder, Paul L. Coe
Publikováno v:
ChemInform. 33:208-208
The fluorination of (+)- chiro -inositol with SF 4 /HF under moderate conditions affords a single product studied by 1 H and 19 F and 13 C NMR spectroscopy. These have been fully assigned with the aid of other physical techniques and compared with a