Výsledky vyhledávání - "Joseph Armand Picard"

Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates

Autor: Helen T. Lee, Brian R. Krause, Bruce D. Roth, R. L. Stanfield, W. H. Roark, Joseph Armand Picard, Drago Robert Sliskovic, R. F. Bousley, K. L. Hamelehle

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:289-294

Sulfoacetic acid, phosphoramidate, and phosphoramide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74ac58e97453c222e55e48824453b5e
https://doi.org/10.1016/s0960-894x(98)00011-0

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Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. The synthesis and biological activity of a series of malonester amides

Autor: Drago Sliskovic, Essenburg Ad, Joseph Armand Picard, J. F. Reindel, L. L. Minton, B.R. Krause, R. L. Stanfield, W. H. Roark

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:713-718

The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s , was shown to be a potent inhibitor of both the intestinal and arterial enzymes, bioactive upon oral dosing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91f0d88d43a22709606ea47b4b323690
https://doi.org/10.1016/0960-894x(96)00098-4

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Inhibitors of acyl-coa:cholesterol acyltransferase (ACAT). 15. sulfonylurea inhibitors with excellent hypocholesterolemic activity in vivo

Autor: Maureen K. Anderson, Reynold Homan, Joseph Armand Picard, R. L. Stanfield, Bruce D. Roth, Brian R. Krause, K. L. Hamelehle, W. Howard Roark, R. F. Bousley

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2367-2370

A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2274c3c7bed1368f9757651e46d528b
https://doi.org/10.1016/0960-894x(95)00408-l

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Palladiumtert-Butyl Peroxide Trifluoroacetate

Autor: Hubert Mimoun, Joseph Armand Picard

Publikováno v: e-EROS Encyclopedia of Reagents for Organic Synthesis

[75123-99-8] C6H9F3O4Pd (MW 308.57) InChI = 1S/C4H10O2.C2HF3O2.Pd/c1-4(2,3)6-5;3-2(4,5)1(6)7;/h5H,1-3H3;(H,6,7);/q;;+2/p-2 InChIKey = BXTWGZGTZHRSST-UHFFFAOYSA-L (oxidizing agent for the selective transformation of terminal alkenes to methyl ketones;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83dc789addad45e12eff9b5156c20d22
https://doi.org/10.1002/047084289x.rp004

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Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors

Autor: Chiu Fai Man, Hussein Hallak, Bruce D. Roth, Joseph Armand Picard, Drago Robert Sliskovic, Daniel F. Ortwine, Alexander Pavlovsky, Johnson Linda Lea, Patrick Michael O'brien, Richard D. Dyer

Publikováno v: Journal of medicinal chemistry. 43(2)

A series of biphenylsulfonamide derivatives of (S)-2-(biphenyl-4-sulfonylamino)-3-methylbutyric acid (5) were prepared and evaluated for their ability to inhibit matrix metalloproteinases (MMPs). For this series of compounds, our objective was to sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfc59e656809cab6f05e7be835b8478
https://pubmed.ncbi.nlm.nih.gov/10649971

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Heterocyclic amides: inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit

Autor: Maureen K. Anderson, R. F. Bousley, Brian R. Krause, Andrew D. White, Joseph Armand Picard, Thomas M.A. Bocan, Sandra Bak Mueller, K. L. Hamelehle, Peter H.U. Lee, J. F. Reindel, R. L. Stanfield, Claude Forsey Purchase

Publikováno v: Journal of medicinal chemistry. 39(20)

A series of heterocyclic amides were synthesized and evaluated as inhibitors of acyl-CoA: cholesterol O-acyltransferase (ACAT) in vitro and for cholesterol lowering in cholesterol-fed rats. Compounds were evaluated for cell-based macrophage ACAT inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32be2210541e61cab58274e6e6aaba8
https://pubmed.ncbi.nlm.nih.gov/8831757

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