PorZ, an Essential Component of the Type IX Secretion System of Porphyromonas gingivalis , Delivers Anionic Lipopolysaccharide to the PorU Sortase for Transpeptidase Processing of T9SS Cargo Proteins

Autor: Mariusz Madej, Zuzanna Nowakowska, Miroslaw Ksiazek, Anna M. Lasica, Danuta Mizgalska, Magdalena Nowak, Anna Jacula, Monika Bzowska, Carsten Scavenius, Jan J. Enghild, Joseph Aduse-Opoku, Michael A. Curtis, F. Xavier Gomis-Rüth, Jan Potempa

Publikováno v: mBio, Vol 12, Iss 1 (2021)

Bacteria have evolved multiple systems to transport effector proteins to their surface or into the surrounding milieu. These proteins have a wide range of functions, including attachment, motility, nutrient acquisition, and toxicity in the host. Porp

Externí odkaz: https://doaj.org/article/da74c30a8ca24a36ba46e4f453049b0e

Generation and characterisation of Porphyromonas gingivalis mutant lacking peptidylarginine deiminase activity

Autor: Estefanía Muñoz-Atienza, Joseph Aduse-Opoku, Magdalena B. Flak, Nikolay A. Paramonov, Costantino Pitzalis, Michael A. Curtis

Publikováno v: Journal of Oral Microbiology, Vol 9, Iss 0 (2017)

Porphyromonas gingivalis peptidylarginine deiminase (PPAD) is the focus of several studies due to its ability to citrullinate in vitro human proteins, which have been linked to the aetiopathogenesis of rheumatoid arthritis (RA). The aim of this work

Externí odkaz: https://doaj.org/article/9df04e6933d743f5a8df5c88214d83c4

Porphyromonas gingivalis regulates TREM-1 in human polymorphonuclear neutrophils via its gingipains.

Autor: Nagihan Bostanci, Thomas Thurnheer, Joseph Aduse-Opoku, Michael A Curtis, Annelies S Zinkernagel, Georgios N Belibasakis

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e75784 (2013)

The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell surface receptor of the immunoglobulin superfamily, with the capacity to amplify pro-inflammatory cytokine production and regulate apoptosis. Polymorphonuclear neutrophils (PMNs)

Externí odkaz: https://doaj.org/article/d6458f426ace4c6f9c59c1a61681fbd0

Structural Model of a Porphyromonas gingivalis type IX Secretion System Shuttle Complex

Autor: Ben, Dorgan, Yichao, Liu, Sunjun, Wang, Joseph, Aduse-Opoku, Sara B-M, Whittaker, Mark A J, Roberts, Christian D, Lorenz, Michael A, Curtis, James A, Garnett

Publikováno v: Journal of Molecular Biology. 434:167871

Porphyromonas gingivalis is a gram-negative oral anaerobic pathogen and is one of the key causative agents of periodontitis. P. gingivalis utilises a range of virulence factors, including the cysteine protease RgpB, to drive pathogenesis and these ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d40b1dba27b46cc640fbfc6de776bee
https://doi.org/10.1016/j.jmb.2022.167871

A 16S rRNA Gene and Draft Genome Database for the Murine Oral Bacterial Community

Autor: Ahmed Hashim, Michael A. Curtis, Sarah C. L. Knowles, Susan Joseph, Ricarda Streich, William G. Wade, Eveliina Hanski, Joseph Aduse-Opoku, Amy B. Pedersen

Publikováno v: mSystems, Vol 6, Iss 1 (2021)
mSystems
Joseph, S, Aduse-Opoku, J, Hashim, A, Hanski, E, Streich, R, Knowles, S C L, Pedersen, A B, Wade, W G, Curtis, M A & Segata, N (ed.) 2021, ' A 16S rRNA gene and draft genome database for the murine oral bacterial community ', mSystems, vol. 6, no. 1, e01222-20 . https://doi.org/10.1128/mSystems.01222-20

Mouse model studies are frequently used in oral microbiome research, particularly to investigate diseases such as periodontitis and caries, as well as other related systemic diseases. We have reported here the details of the development of a curated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974b26c73f2f350cf303c11f797e0a41
https://journals.asm.org/doi/10.1128/mSystems.01222-20