Výsledky vyhledávání - "Joseph A. Swintek"

Targeted Pathway-based In Vivo Testing Using Thyroperoxidase Inhibition to Evaluate Plasma Thyroxine as a Surrogate Metric of Metamorphic Success in Model Amphibian Xenopus laevis

Autor: Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung

Publikováno v: Toxicol Sci

Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0f2fa073d9a14784133cb3ac98477b
https://doi.org/10.1093/toxsci/kfaa036

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Editor’s Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity

Autor: Carlie A. LaLone, Henry W. Helgen, Travis W. Saari, Serina L. Robinson, Gerald T. Ankley, David Lyons, Daniel L. Villeneuve, Joseph A. Swintek

Publikováno v: Toxicological Sciences. 153:228-245

Conservation of a molecular target across species can be used as a line-of-evidence to predict the likelihood of chemical susceptibility. The web-based Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS; https://seqapass.epa.gov/se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362d8d2adc6206143a83a9af9b2358fe
https://doi.org/10.1093/toxsci/kfw119

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