Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Joseph A. Spernyak"'
Autor:
Farukh A. Durrani, Joseph Cacaccio, Steven G. Turowski, Mykhaylo Dukh, Wiam Bshara, Leslie Curtin, Sandra Sexton, Joseph A. Spernyak, Ravindra K. Pandey
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115731- (2023)
Photobac is a near infrared photosensitizer (PS) derived from naturally occurring bacteriochlorophyll- a, with a potential for treating a variety of cancer types (U87, F98 and C6 tumor cells in vitro). The main objective of the studies presented here
Externí odkaz:
https://doaj.org/article/2e5f1a6a8be546bb9b7c859c978155ad
Autor:
Wen (Jess) Li, Yunfei Wang, Xiaozhuo Liu, Shan Wu, Moyi Wang, Steven G. Turowski, Joseph A. Spernyak, Amanda Tracz, Ahmed M. Abdelaal, Kasireddy Sudarshan, Igor Puzanov, Gurkamal Chatta, Andrea L. Kasinski, Dean G. Tang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2123 (2024)
Prostate cancer (PCa) remains a common cancer with high mortality in men due to its heterogeneity and the emergence of drug resistance. A critical factor contributing to its lethality is the presence of prostate cancer stem cells (PCSCs), which can s
Externí odkaz:
https://doaj.org/article/e53665e2fdbf4db98c8a6545b64a0204
Autor:
Swati D. Sonkawade, Shirley Xu, Minhyung Kim, Sarmila Nepali, Victoire-Grace Karambizi, Sandra Sexton, Steven G. Turowski, Kunpeng Li, Joseph A. Spernyak, Jonathan F. Lovell, Anthony George, Sujit Suwal, Umesh C. Sharma, Saraswati Pokharel
Publikováno v:
Cells, Vol 12, Iss 12, p 1589 (2023)
Background: Cardioprotective effects of N-acetyl-ser-asp-lys-pro (Ac-SDKP) have been reported in preclinical models of myocardial remodeling. However, the rapid degradation of this endogenous peptide in vivo limits its clinical use. Method: To prolon
Externí odkaz:
https://doaj.org/article/5d1e6d7baa66477393818bb394aeef47
Autor:
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activatio
Externí odkaz:
https://doaj.org/article/3d0a007713ee43918ce086163783b2d9
Autor:
Jossana A. Damasco, Tymish Y. Ohulchanskyy, Supriya Mahajan, Guanying Chen, Ajay Singh, Hilliard L. Kutscher, Haoyuan Huang, Steven G. Turowski, Joseph A. Spernyak, Anurag K. Singh, Jonathan F. Lovell, Mukund Seshadri, Paras N. Prasad
Publikováno v:
Cancer Nanotechnology, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract Background In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contras
Externí odkaz:
https://doaj.org/article/c6b66bbd55104f199353f38e01ebb735
Autor:
Ballav M. Borah, Joseph Cacaccio, Farukh A. Durrani, Wiam Bshara, Steven G. Turowski, Joseph A. Spernyak, Ravindra K. Pandey
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract This article presents the construction of a multimodality platform that can be used for efficient destruction of brain tumor by a combination of photodynamic and sonodynamic therapy. For in vivo studies, U87 patient-derived xenograft tumors
Externí odkaz:
https://doaj.org/article/a02153428d9443d0abc09e951259cca0
Autor:
Umesh C. Sharma, Swati D. Sonkawade, Andrew Baird, Min Chen, Shirley Xu, Sandra Sexton, Anurag K. Singh, Adrienne Groman, Steven G. Turowski, Joseph A. Spernyak, Supriya D. Mahajan, Saraswati Pokharel
Publikováno v:
Cardio-Oncology, Vol 4, Iss 1, Pp 1-14 (2018)
Abstract Background Cancer survivors treated with thoracic ionizing radiation are at higher risk of premature death due to myocardial ischemia. No therapy is currently available to prevent or mitigate these effects. We tested the hypothesis that an e
Externí odkaz:
https://doaj.org/article/5f16c7bc9a434402adff2aa1fdd3c689
Autor:
Akanksha Patel, Didar Asik, Eric M. Snyder, Joseph A. Spernyak, Paul J. Cullen, Janet R. Morrow
Publikováno v:
Magnetochemistry, Vol 6, Iss 3, p 41 (2020)
The development of MRI probes is of interest for labeling antibiotic-resistant fungal infections based on yeast. Our work showed that yeast cells can be labeled with high-spin Fe(III) complexes to produce enhanced T2 water proton relaxation. These Fe
Externí odkaz:
https://doaj.org/article/e7bb30bf1b5341f683e84fa92e0e24ae
Autor:
Didar Asik, Rachel Smolinski, Samira M. Abozeid, Travis B. Mitchell, Steven G. Turowski, Joseph A. Spernyak, Janet R. Morrow
Publikováno v:
Molecules, Vol 25, Iss 10, p 2291 (2020)
Complexes of Fe(III) that contain a triazacyclononane (TACN) macrocycle, two pendant hydroxyl groups, and a third ancillary pendant show promise as MRI contrast agents. The ancillary group plays an important role in tuning the solution relaxivity of
Externí odkaz:
https://doaj.org/article/edaf2a4ca2834f67bb9641cc34eaf876
Autor:
Mukund Seshadri, Joseph A. Spernyak, Patricia G. Maier, Richard T. Cheney, Richard Mazurchuk, David A. Bellnier
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 2, Pp 128-135 (2007)
The acute effects of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) were investigated in vivo using intravital microscopy (IVM) and magnetic resonance imaging (MRI). Changes in vascular permeability and blood flow of synge
Externí odkaz:
https://doaj.org/article/034cb093d4074403b370653b9f834fcd