Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Joseph A. Sennello"'
Autor:
Srishti U. Sahu, M. Scott Bowers, Luisa P. Cacheaux, Joseph A. Sennello, Katherine Leaderbrand, Mary E. Schmidt, Joseph R. Moskal, M. Amin Khan, Roger A. Kroes
Publikováno v:
Journal of Neurochemistry
N‐methyl‐d‐aspartate receptors (NMDARs) mediate both physiological and pathophysiological processes, although selective ligands lack broad clinical utility. NMDARs are composed of multiple subunits, but N‐methyl‐d‐aspartate receptor subun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b46cab2807da9a4bb10479a5c931ac
http://europepmc.org/articles/PMC7065110
http://europepmc.org/articles/PMC7065110
Autor:
Paul Cheresh, Cara J. Gottardi, Anna P. Lam, G. R. Scott Budinger, Sergejs Berdnikovs, David W. Kamp, Joseph A. Sennello, Alexander V. Misharin, John Varga, Annette S. Flozak
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 56:191-201
Previous studies established that attenuating Wnt/β-catenin signaling limits lung fibrosis in the bleomycin mouse model of this disease, but the contribution of this pathway to distinct lung cell phenotypes relevant to tissue repair and fibrosis rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16951b0d03b4cbb70c61658699078d6b
https://doi.org/10.1165/rcmb.2016-0147oc
https://doi.org/10.1165/rcmb.2016-0147oc
We previously demonstrated that mice lacking the Wnt co-receptor, Lrp5, had attenuated pulmonary fibrosis in the bleomycin model. We found that Arginase 1 (Arg1), an enzyme that converts L-arginine to urea and ornithine, was markedly elevated in Lrp5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060835cd3bbc449aeec635ad8e14532b
https://doi.org/10.1101/137539
https://doi.org/10.1101/137539
Autor:
Maria Pini, Raja Fayad, Melissa E. Gove, Robert J. Cabay, Venkatesh Ponemone, Giamila Fantuzzi, Joseph A. Sennello, Charles A. Dinarello, Britta Siegmund
Publikováno v:
Proceedings of the National Academy of Sciences. 105:8085-8090
Obesity is associated with increased severity of acute pancreatitis (AP). The cytokines IL-18 and IL-12 are elevated in patients with AP, and IL-18 levels are high in obesity. We aimed to develop a pathologically relevant model to study obesity-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec2a2c7f7727712c6ee674b0fb8f8c4
https://doi.org/10.1073/pnas.0804091105
https://doi.org/10.1073/pnas.0804091105
Autor:
Joseph A. Sennello, Melissa E. Gove, Jantine W. P. M. van Baal, Maria Pini, Lawrence Chan, Giamila Fantuzzi
Publikováno v:
Endocrinology. 149:4080-4085
Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e86dd9fc9233285b604a5dd004440a8
https://doi.org/10.1210/en.2008-0327
https://doi.org/10.1210/en.2008-0327
Publikováno v:
Cytokine. 36:261-266
Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including thymus atrophy and markedly reduced inflammatory responses. We evaluated whether transplantation of wild type (WT) white adipose tissue (WAT) into ob/ob mice co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d2f5c97e21b9c8f42301f63134ac29
https://doi.org/10.1016/j.cyto.2007.02.001
https://doi.org/10.1016/j.cyto.2007.02.001
Publikováno v:
Endocrinology. 147:5019-5022
Adiponectin (APN) is an adipocyte-derived protein that regulates insulin sensitivity and displays antiinflammatory activities in a variety of experimental models. The present study aimed at investigating the effect of APN deficiency on the inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110c9b34ab69309a38ef43a86d3ca07d
https://doi.org/10.1210/en.2006-0855
https://doi.org/10.1210/en.2006-0855
Autor:
Joseph A. Sennello, Giorgio Senaldi, Hans A. Lehr, Charles A. Dinarello, Britta Siegmund, Giamila Fantuzzi
Publikováno v:
European Journal of Immunology. 34:2356-2364
The transcription factor IFN regulatory factor-1 (IRF-1) regulates production and activity of many inflammatory mediators and cells. Here, we investigated the role of IRF-1 in intestinal inflammation using clinical and histologic scores; inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b1021ee25ee3b50a5d7add890c4338
https://doi.org/10.1002/eji.200425124
https://doi.org/10.1002/eji.200425124
Autor:
Giamila Fantuzzi, Britta Siegmund, Joseph A. Sennello, Hans A. Lehr, I. Fedke, Martin Zeitz, Arvind Batra
Publikováno v:
Journal of Leukocyte Biology. 76:782-786
Leptin-deficient (ob/ob) mice are resistant in different models of autoimmunity and inflammation, suggesting that leptin regulates immunity and inflammation. To investigate whether leptin deficiency modulates the spontaneous intestinal inflammation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c41c09c5a79af2aa52eef1ad592682
https://doi.org/10.1189/jlb.0404239
https://doi.org/10.1189/jlb.0404239
Autor:
Arvind Batra, I. Fedke, Jessica Jones-Carson, F Gamboni-Robertson, Giamila Fantuzzi, Martin Zeitz, Hans-Anton Lehr, Joseph A. Sennello, Britta Siegmund
Publikováno v:
Gut. 53:965-972
Background: Leptin regulates appetite through the long isoform of its receptor in the hypothalamus. Although leptin regulates immune responses, it is still unknown whether a direct effect of leptin on lymphocytes is required. Aims: To clarify whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1f7fcb852e07ed1361e6aa521b49f2
https://doi.org/10.1136/gut.2003.027136
https://doi.org/10.1136/gut.2003.027136