Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Joseph A. Scherman"'
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Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis
Autor: Thomas M. Nosek, Christopher E Stoddard, Jinhua Shen, Héctor H. Valdivia, Wen Mei Yu, Cheng-Kui Qu, Caiying Guo, Joseph A. Scherman, Marco Brotto
Publikováno v: Nature Cell Biology. 11:769-776
The intracellular Ca(2+) concentration ([Ca(2+)](i)) in skeletal muscles must be rapidly regulated during the excitation-contraction-relaxation process. However, the signalling components involved in such rapid Ca(2+) movement are not fully understoo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ce5c19352b3478e517ec79192559b4
https://doi.org/10.1038/ncb1884
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3
A Mutation Associated with Catecholaminergic Polymorphic Ventricular Tachycardia in the Cardiac Ryanodine Receptor (RyR2-V2475F) Yields a Highly Arrhythmogenic Channel
Autor: Héctor H. Valdivia, Timothy A. Hacker, Nancy A. Benkusky, Manorama Jones, Joseph A. Scherman, Pat A. Powers, Craig Weber
Publikováno v: Biophysical Journal. 96(3)
Mutations in RYR2, the gene encoding for the cardiac ryanodine receptor (RyR2), are associated with Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), an arrhythmogenic syndrome characterized by the development of adrenergically-mediated v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117b11af86dbb2d3d47e49599a30b529
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4
Abstract 1580: Phosphorylation of Myosin Binding Protein C Contributes to the Force-Frequency Response and Beta-Adrenergic Enhancement of Cardiac Contraction
Autor: Héctor H. Valdivia, Xin Wu, Mariappan Muthuchamy, Richard L. Moss, Joseph A. Scherman, Carl W. Tong
Publikováno v: Circulation. 118
Beta-adrenergic agonists enhance cardiac function by increasing contractility, lusitropy and heart rate. We propose that phosphorylation of myosin binding protein C (cMyBP-C), a thick filament accessory protein, plays a key role in adrenergic modulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8de60f2a8b24bc70778fcc3059392242
https://doi.org/10.1161/circ.118.suppl_18.s_350-b
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5
Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808
Autor: Héctor H. Valdivia, Scott M. MacDonnell, Hajime Kubo, Gerardo García-Rivas, Joseph A. Scherman, Steven R. Houser, Xiongwen Chen
Publikováno v: Circulation research. 102(8)
The sympathetic nervous system is a critical regulator of cardiac function (heart rate and contractility) in health and disease. Sympathetic nervous system agonists bind to adrenergic receptors that are known to activate protein kinase A, which phosp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a1ce63f253ad9ed5f0f77d7898b706
https://pubmed.ncbi.nlm.nih.gov/18596257
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6
Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor
Autor: Héctor H. Valdivia, Timothy A. Hacker, Craig Weber, Emily F. Farrell, Manorama C. John, Joseph A. Scherman, Patricia A. Powers, Nancy A. Benkusky
Publikováno v: Circulation research. 101(8)
Increased phosphorylation of the cardiac ryanodine receptor (RyR)2 by protein kinase A (PKA) at the phosphoepitope encompassing Ser2808 has been advanced as a central mechanism in the pathogenesis of cardiac arrhythmias and heart failure. In this sch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cda5b74f4b989752b31e4451a919319
https://pubmed.ncbi.nlm.nih.gov/17932330
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Plný text Recenzováno Digitální knihovna AV ČR
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